Towards an integrated venomics approach for accelerated conopeptide discovery

Toxicon

Volumn 60, Issue 4, 2012, Pages 470-477

  Prashanth, Jutty Rajan ^a   Lewis, Richard J ^a   Dutertre, Sébastien ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cone snails; Conotoxins; Mass spectrometry; Next generation sequencing; Venomics

Indexed keywords

CONOPEPTIDE; CONOTOXIN; PEPTIDE; SNAIL VENOM; TRANSCRIPTOME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; BIOMICS; CONUS SNAIL; DATA ANALYSIS; EVOLUTION; EXPRESSED SEQUENCE TAG; FRACTIONATION; GENE EXPRESSION PROFILING; HIGH THROUGHPUT SCREENING; INFORMATION PROCESSING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEOMICS; PYROSEQUENCING; SEQUENCE ANALYSIS; SEQUENCE DATABASE; TRANSCRIPTOMICS; VENOMICS;

ANIMALS; COMPUTATIONAL BIOLOGY; CONOTOXINS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; PEPTIDES; PROTEOME; PROTEOMICS; SEQUENCE ANALYSIS, PROTEIN; SNAILS; TRANSCRIPTOME; VENOMS;

GASTROPODA; MAMMALIA;

EID: 84863780154     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.04.340     Document Type: Article

References (44)

1. Abdel-Rahman M.A., Abdel-Nabi I.M., El-Naggar M.S., Abbas O.A., Strong P.N. Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2011, 154:318-325.
2. Biass D., Dutertre S., Gerbault A., Menou J.-L., Offord R., Favreau P., Stöcklin R. Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. Journal of Proteomics 2009, 72:210-218.
3. Biggs J.S., Olivera B.M., Kantor Y.I. α-Conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon 2008, 52:101-105.
4. Buczek O., Bulaj G., Olivera B. Conotoxins and the posttranslational modification of secreted gene products. Cellular and Molecular Life Sciences 2005, 62:3067-3079.
5. Buczek O., Yoshikami D., Bulaj G., Jimenez E.C., Olivera B.M. Post-translational amino acid isomerization. Journal of Biological Chemistry 2005, 280:4247-4253.
6. Davis J., Jones A., Lewis R.J. Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides 2009, 30:1222-1227.
7. Dutertre S., Biass D., Stöcklin R., Favreau P. Dramatic intraspecimen variations within the injected venom of Conus consors: an unsuspected contribution to venom diversity. Toxicon 2010, 55:1453-1462.
8. Dutertre S., Lewis R.J. Cone Snail Biology, Bioprospecting and Conservation, Snails: Biology, Ecology and Conservation 2012, Nova Science Publishers, Inc, New York, 85-105 pp.
9. Escoubas P., Quinton L., Nicholson G.M. Venomics: unravelling the complexity of animal venoms with mass spectrometry. Journal of Mass Spectrometry 2008, 43:279-295.
10. Favreau P., Menin L., Michalet S., Perret F., Cheneval O., Stöcklin M., Bulet P., Stöcklin R. Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen. Toxicon 2006, 47:676-687.
11. Favreau P., Stöcklin R. Marine snail venoms: use and trends in receptor and channel neuropharmacology. Current Opinion in Pharmacology 2009, 9:594-601.
12. Grzegorz B. Integrating the discovery pipeline for novel compounds targeting ion channels. Current Opinion in Chemical Biology 2008, 12:441-447.
13. 2+ channels. Neuron 1992, 9:69-77.
14. Hu H., Bandyopadhyay P., Olivera B., Yandell M. Characterization of the Conus bullatus genome and its venom-duct transcriptome. BMC Genomics 2011, 12:60.
15. Jakubowski J.A., Kelley W.P., Sweedler J.V., Gilly W.F., Schulz J.R. Intraspecific variation of venom injected by fish-hunting Conus snails. Journal of Experimental Biology 2005, 208:2873-2883.
16. Jones A., Bingham J.P., Gehrmann J., Bond T., Loughnan M., Atkins A., Lewis R.J., Alewood P.F. Isolation and characterization of conopeptides by high performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry. Rapid Communications in Mass Spectrometry 1996, 10:138-143.
17. Kaas Q., Westermann J.C., Halai R., Wang C.K.L., Craik D.J. ConoServer, a database for conopeptide sequences and structures. Bioinformatics 2008, 24:445-446.
18. Kaas Q., Yu R., Jin A.H., Dutertre S., Craik D.J. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research 2011, 40:D325-D330.
19. Kalume D.E., Stenflo J., Czerwiec E., Hambe B., Furie B.C., Furie B., Roepstorff P. Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization mass spectrometry and biochemical methods. Journal of Mass Spectrometry 2000, 35:145-156.
20. Lewis R.J. Conotoxin venom peptide therapeutics. Pharmaceutical Biotechnology 2009, 44-48. Springer, New York. C.A. Guzmán, G.Z. Feuerstein (Eds.).
21. Lewis R.J., Dutertre S., Vetter I., McDonald C.J. Conus venom peptide pharmacology. Pharmacological Reviews 2012, 64:259-298.
22. Lewis R.J., Garcia M.L. Therapeutic potential of venom peptides. Nature Reviews Drug Discovery 2003, 2:790-802.
23. Loughnan M.L., Nicke A., Jones A., Adams D.J., Alewood P.F., Lewis R.J. Chemical and functional identification and characterization of novel sulfated α-conotoxins from the cone snail Conus anemone. Journal of Medicinal Chemistry 2004, 47:1234-1241.
24. Mandal A., Ramasamy M., Sabareesh V., Openshaw M., Krishnan K., Balaram P. Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry. Journal of the American Society for Mass Spectrometry 2007, 18:1396-1404.
25. Ménez A., Stöcklin R., Mebs D. 'Venomics' or: the venomous systems genome project. Toxicon 2006, 47:255-259.
26. Naamati G., Askenazi M., Linial M. ClanTox: a classifier of short animal toxins. Nucleic Acids Research 2009, 37:363-368.
27. Nair S.S., Nilsson C.L., Emmett M.R., Schaub T.M., Gowd K.H., Thakur S.S., Krishnan K.S., Balaram P., Marshall A.G. De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry. Analytical Chemistry 2006, 78:8082-8088.
28. Olivera B.M. EE Just Lecture, 1996. Molecular Biology of the Cell 1997, 8:2101-2109.
29. Olivera B.M. Conus peptides: biodiversity-based discovery and exogenomics. Journal of Biological Chemistry 2006, 281:31173-31177.
30. Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L., Dong M., Chen S., Xu A. Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics 2006, 88:809-819.
31. Pi C., Liu Y., Peng C., Jiang X., Liu J., Xu B., Yu X., Yu Y., Jiang X., Wang L., Dong M., Chen S., Xu A.-L. Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins. Biochimie 2006, 88:131-140.
32. Quinton L., Caer J.-P.L., Vinh J., Gilles N., Chamot-Rooke J. Fourier transform mass spectrometry: a powerful tool for toxin analysis. Toxicon 2006, 47:715-726.
33. Romeo C., Di Francesco L., Oliverio M., Palazzo P., Massilia G.R., Ascenzi P., Polticelli F., Schininà M.E. Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation. Journal of Separation Science 2008, 31:488-498.
34. Safavi-Hemami H., Young N.D., Williamson N.A., Purcell A.W. Proteomic interrogation of venom delivery in marine cone snails: novel insights into the role of the venom bulb. Journal of Proteome Research 2010, 9:5610-5619.
35. Sandall D.W., Satkunanathan N., Keays D.A., Polidano M.A., Liping X., Pham V., Down J.G., Khalil Z., Livett B.G., Gayler K.R. A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 2003, 42:6904-6911.
36. Shendure J., Ji H. Next-generation DNA sequencing. Nature Biotechnology 2008, 26:1135-1145.
37. Sudarslal S., Singaravadivelan G., Ramasamy P., Ananda K., Sarma S.P., Sikdar S.K., Krishnan K.S., Balaram P. A novel 13 residue acyclic peptide from the marine snail, Conus monile, targets potassium channels. Biochemical and Biophysical Research Communications 2004, 317:682-688.
38. Tan P.T.J., Khan A.M., Brusic V. Bioinformatics for venom and toxin sciences. Briefings in Bioinformatics 2003, 4:53-62.
39. Terlau H., Olivera B.M. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiological Reviews 2004, 84:41-68.
40. Terrat Y., Biass D., Dutertre S.b., Favreau P., Remm M., Stöcklin R., Piquemal D., Ducancel F.d.r. High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors. Toxicon 2012, 59:34-46.
41. Ueberheide B.M., Fenyö D., Alewood P.F., Chait B.T. Rapid sensitive analysis of cysteine rich peptide venom components. Proceedings of the National Academy of Sciences 2009, 106:6910-6915.
42. Vetter I., Davis J.L., Rash L.D., Anangi R., Mobli M., Alewood P.F., Lewis R.J., King G.F. Venomics: a new paradigm for natural products-based drug discovery. Amino Acids 2011, 40:15-28.
43. Vetter I., Lewis R.J. Characterization of endogenous calcium responses in neuronal cell lines. Biochemical Pharmacology 2010, 79:908-920.
44. Zheng W., Spencer R.H., Kiss L. High throughput assay technologies for ion channel drug discovery. Assay and Drug Development Technologies 2004, 2:543-552.