Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity

Toxicon

Volumn 55, Issue 8, 2010, Pages 1453-1462

  Dutertre, Sébastien ^a   Biass, Daniel ^a   Stöcklin, Reto ^a   Favreau, Philippe ^a  

^a ATHERIS LABORATORIES   (Switzerland)

Author keywords

Conopeptide; Conus consors; Intraspecimen variation; Mass spectrometry; Venom

Indexed keywords

CONOTOXIN; PEPTIDE; SNAIL VENOM;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CONUS CONSORS; CONUS SNAIL; ELECTROSPRAY MASS SPECTROMETRY; ENVENOMATION; FOLLOW UP; INTRASPECIFIC VARIATION; LIQUID CHROMATOGRAPHY; NONHUMAN; ONLINE ANALYSIS; PISCIVORE; PRIORITY JOURNAL; SPECIES COMPARISON; SPECIES DIVERSITY; TOXIN ANALYSIS; TOXIN STRUCTURE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONUS SNAIL; MOLLUSK VENOMS; PEPTIDE MAPPING; SPECIES SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA; CONUS CONSORS; GASTROPODA;

EID: 77952243217     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.02.025     Document Type: Article

References (40)

1. Abdel-Rahman M.A., Omran M.A., bdel-Nabi I.M., Ueda H., McVean A. Intraspecific variation in the Egyptian scorpion Scorpio maurus palmatus venom collected from different biotopes. Toxicon 2009, 53:349-359.
2. Benoit, E., Favreau, P., Schlumberger, S., Cordova, MA., Tytgat, J., Stöcklin, R., Molgo, J., 2008. A new mu-conotoxin from Conus consors that atypically targets sodium channels in unmyelinated and myelinated nerve fibers. In: Abstract Book. 16th European Section Meeting of the International Society on Toxinology.
3. Biass D., Dutertre S., Gerbault A., Menou J.L., Offord R., Favreau P., Stöcklin R. Comparative proteomic study of the venom of the piscivorous cone snail Conus consors. Journal of Proteomics 2009, 72:210-218.
4. Biggs J.S., Olivera B.M., Kantor Y.I. Alpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius. Toxicon 2008, 52:101-105.
5. Bingham J.P., Jones A., Lewis R.J., Andrew P.R., Alewood D. Conus venom peptides (conopeptides): inter-species, intra-species and within individual variation revealed by ionspray mass spectrometry. Biomedical Aspects of Marine Pharmacology 1996, Alaken, Fort Collins. E. Lazarovici, M.E. Spira, E. Zlotkin (Eds.).
6. Creer S., Malhotra A., Thorpe R.S., Stöcklin R.S., Favreau P.S., Hao Chou W.S. Genetic and ecological correlates of intraspecific variation in pitviper venom composition detected using matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF-MS) and isoelectric focusing. Journal of Molecular Evolution 2003, 56:317-329.
7. Davis J., Jones A., Lewis R.J. Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides 2009, 30:1222-1227.
8. Duda T.F., Remigio E.A. Variation and evolution of toxin gene expression patterns of six closely related venomous marine snails. Molecular Ecology 2008, 17:3018-3032.
9. Duda T.F. Differentiation of venoms of predatory marine gastropods: divergence of orthologous toxin genes of closely related Conus species with different dietary specializations. Journal of Molecular Evolution 2008, 67:315-321.
10. Dutertre S., Ulens C., Buttner R., Fish A., van Elk R., Kendel Y., Hopping G., Alewood P.F., Schroeder C., Nicke A., Smit A.B., Sixma T.K., Lewis R.J. AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO Journal 2007, 26:3858-3867.
11. Escoubas P., Quinton L., Nicholson G.M. Venomics: unravelling the complexity of animal venoms with mass spectrometry. Journal of Mass Spectrometry 2008, 43:279-295.
12. Favreau P., Gilles N., Lamthanh H., Bournaud R., Shimahara T., Bouet F., Laboute P., Letourneux Y., Menez A., Molgo J., Le G.F. A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity. Biochemistry 2001, 40:14567-14575.
13. Favreau P., Krimm I., Le G.F., Bobenrieth M.J., Lamthanh H., Bouet F., Servent D., Molgo J., Menez A., Letourneux Y., Lancelin J.M. Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors. Biochemistry 1999, 38:6317-6326.
14. Favreau P., Menin L., Michalet S., Perret F., Cheneval O., Stöcklin M., Bulet P., Stöcklin R. Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen. Toxicon 2006, 47:676-687.
15. Favreau, P., Stöcklin, R., 2009. Marine snail venoms: use and trends in receptor and channel neuropharmacology. Current Opinion in Pharmacology.
16. Gubensek F., Sket D., Turk V., Lebez D. Fractionation of Vipera ammodytes venom and seasonal variation of its composition. Toxicon 1974, 12:167-171.
17. Herzig V., Hodgson W.C. Intersexual variations in the pharmacological properties of Coremiocnemis tropix (Araneae, Theraphosidae) spider venom. Toxicon 2009, 53:196-205.
18. Herzig V., Khalife A.A., Chong Y., Isbister G.K., Currie B.J., Churchill T.B., Horner S., Escoubas P., Nicholson G.M., Hodgson W.C. Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom. Toxicon 2008, 51:1167-1177.
19. Hopkins C., Grilley M., Miller C., Shon K.J., Cruz L.J., Gray W.R., Dykert J., Rivier J., Yoshikami D., Olivera B.M. A new family of Conus peptides targeted to the nicotinic acetylcholine receptor. Journal of Biological Chemistry 1995, 270:22361-22367.
20. Inceoglu B., Lango J., Jing J., Chen L., Doymaz F., Pessah I.N., Hammock B.D. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proceedings of the National Academy of Sciences U.S.A 2003, 100:922-927.
21. Jakubowski J.A., Kelley W.P., Sweedler J.V., Gilly W.F., Schulz J.R. Intraspecific variation of venom injected by fish-hunting Conus snails. Journal of Experimental Biology 2005, 208:2873-2883.
22. Le Gall F., Favreau P., Benoit E., Mattei C., Bouet F., Menou J.L., Menez A., Letourneux Y., Molgo J. A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism. European Journal of Neuroscience 1999, 11:3134-3142.
23. Lewis R.J. Conotoxins: molecular and therapeutic targets. Progress in Molecular and Subcellular Biology 2009, 46:45-65.
24. Lewis R.J., Garcia M.L. Therapeutic potential of venom peptides. Nature Reviews Drug Discovery 2003, 2:790-802.
25. Marshall J., Kelley W.P., Rubakhin S.S., Bingham J.P., Sweedler J.V., Gilly W.F. Anatomical correlates of venom production in Conus californicus. Biological Bulletin 2002, 203:27-41.
26. Menezes M.C., Furtado M.F., Travaglia-Cardoso S.R., Camargo A.C., Serrano S.M. Sex-based individual variation of snake venom proteome among eighteen Bothrops jararaca siblings. Toxicon 2006, 47:304-312.
27. Miljanich G.P. Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. Current Medicinal Chemistry 2004, 11:3029-3040.
28. Milne T.J., Abbenante G., Tyndall J.D., Halliday J., Lewis R.J. Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry 2003, 278:31105-31110.
29. Olivera B.M., Rivier J., Clark C., Ramilo C.A., Corpuz G.P., Abogadie F.C., Mena E.E., Woodward S.R., Hillyard D.R., Cruz L.J. Diversity of Conus neuropeptides. Science 1990, 249:257-263.
30. Olivera B.M., Walker C., Cartier G.E., Hooper D., Santos A.D., Schoenfeld R., Shetty R., Watkins M., Bandyopadhyay P., Hillyard D.R. Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns. Annals of the New York Academy of Sciences 1999, 870:223-237.
31. Power A.J., Keegan B.F., Nolan K. The seasonality and role of the neurotoxin tetramine in the salivary glands of the red whelk Neptunea antiqua (L.). Toxicon 2002, 40:419-425.
32. Queiroz G.P., Pessoa L.A., Portaro F.C., Furtado M.F., Tambourgi D.V. Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus. Toxicon 2008, 52:842-851.
33. Romeo C., Di F.L., Oliverio M., Palazzo P., Massilia G.R., Ascenzi P., Polticelli F., Schinina M.E. Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation. Journal of Separation Science 2008, 31:488-498.
34. Silveira P.V., Nishioka S.A. Venomous snake bite without clinical envenoming ('dry-bite'). A neglected problem in Brazil. Tropical and Geographical Medicine 1995, 47:82-85.
35. Stöcklin R., Mebs D., Boulain J.C., Panchaud P.A., Virelizier H., Gillard-Factor C. Identification of snake species by toxin mass fingerprinting of their venoms. Methods in Molecular Biology 2000, 146:317-335.
36. Teichert R.W., Rivier J., Dykert J., Cervini L., Gulyas J., Bulaj G., Ellison M., Olivera B.M. AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors. Toxicon 2004, 44:207-214.
37. Ueberheide B.M., Fenyo D., Alewood P.F., Chait B.T. Rapid sensitive analysis of cysteine rich peptide venom components. Proceedings of the National Academy of Sciences U.S.A 2009, 106:6910-6915.
38. Vianna Braga M.C., Konno K., Portaro F.C., de Freitas J.C., Yamane T., Olivera B.M., Pimenta D.C. Mass spectrometric and high performance liquid chromatography profiling of the venom of the Brazilian vermivorous mollusk Conus regius: feeding behavior and identification of one novel conotoxin. Toxicon 2005, 45:113-122.
39. Wang L., Liu J., Pi C., Zeng X., Zhou M., Jiang X., Chen S., Ren Z., Xu A. Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents. Archives of Toxicology 2009, 2009 Jun 27. (Epub ahead of print).
40. Zhang M.M., Fiedler B., Green B.R., Catlin P., Watkins M., Garrett J.E., Smith B.J., Yoshikami D., Olivera B.M., Bulaj G. Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels. Biochemistry 2006, 45:3723-3732.