Modeling of ion-pairing effect in peptide reversed-phase chromatography

Journal of Chromatography A

Volumn 1249, Issue , 2012, Pages 92-102

  Gétaz, David ^a   Hariharan, Subrahmaniam B ^a   Butté, Alessandro ^b   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

^b LONZA AG   (Switzerland)

Author keywords

Adsorption; Chromatography; Counterion; Modeling; Peptide; Reversed phase

Indexed keywords

CHARGED FUNCTIONAL GROUPS; COUNTERION BINDING; COUNTERIONS; DESIGN AND DEVELOPMENT; DEVELOPED MODEL; INDUSTRIAL SCALE; ION-PAIRING; K-MODELS; MEASUREMENT TECHNIQUES; MOBILE PHASIS; MOBILE-PHASE COMPOSITION; MODEL PARAMETERS; NET CHARGES; ORGANIC MODIFIER; PREPARATIVE CHROMATOGRAPHY; PURIFICATION PROCESS; RETENTION MODELS; REVERSED PHASE; REVERSED-PHASE CHROMATOGRAPHY; SATURATION CAPACITIES;

ACETONITRILE; ADSORPTION; CHROMATOGRAPHY; FUNCTIONAL GROUPS; IONS; MODELS;

PEPTIDES;

ACETIC ACID; ACETONITRILE; ACID ANHYDRIDE; COUNTERION; PHOSPHORIC ACID; TRIFLUOROACETIC ACID;

ARTICLE; BINDING KINETICS; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATHEMATICAL ANALYSIS; PEPTIDE PURIFICATION; PRIORITY JOURNAL; PURIFICATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; STOICHIOMETRY;

CHROMATOGRAPHY, LIQUID; IONS; MODELS, THEORETICAL; OSMOLAR CONCENTRATION; PEPTIDES;

APIS;

EID: 84863776833     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.06.005     Document Type: Article

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