Artesunate inhibits cell proliferation and decreases growth hormone synthesis and secretion in GH3 cells

Molecular Biology Reports

Volumn 39, Issue 5, 2012, Pages 6227-6234

  Mao, Zhi Gang ^a   Zhou, Jing ^b   Wang, Hui ^b   He, Dong Sheng ^a   Xiao, Wei Wei ^b   Liao, Gui Zhi ^b   Qiu, Lu Bin ^c   Zhu, Yong Hong ^b   Wang, Hai Jun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c NONE

Author keywords

Apoptosis; Apoptosis induce factor; Artesunate; Caspase; Growth hormone adenomas

Indexed keywords

APOPTOSIS INDUCING FACTOR; ARTESUNATE; CASPASE; GROWTH HORMONE; MESSENGER RNA; ARTEMISININ DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN GH3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HORMONE RELEASE; HORMONE SYNTHESIS; IC 50; MITOSIS INHIBITION; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; MESENCHYMAL STEM CELL; METABOLISM; SECRETION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ARTESUNATE; RATTUS;

ANIMALS; APOPTOSIS; ARTEMISININS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; FIBROBLASTS; GENE EXPRESSION REGULATION; GROWTH HORMONE; MESENCHYMAL STEM CELLS; MICE; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84863770630     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1442-6     Document Type: Article

References (43)

1. Asa SL, Ezzat S (2002) The pathogenesis of pituitary tumours. Nat Rev Cancer 2:836-849
2. Gola M, Doga M, Bonadonna S, Mazziotti G, Vescovi PP, Giustina A (2006) Neuroendocrine tumors secreting growth hormone- releasing hormone: pathophysiological and clinical aspects. Pituitary 9:221-229
3. Chen B, Moreland J, Zhang J (2011) Human brain functional MRI and DTI visualization with virtual reality. Quant Imaging Med Surg 1:11-16
4. Melmed S (2009) Acromegaly pathogenesis and treatment. J Clin Invest 119:3189-3202
5. Castinetti F, Morange I, Dubois N, Albarel F, Conte-Devolx B, Dufour H, Brue T (2009) Does first-line surgery still have its place in the treatment of acromegaly? Ann Endocrinol (Paris) 70:107-112
6. Situ D, Wang J, Shao W, Zhu ZH (2011) Assessment and treatment of cancer pain: from Western to Eastern. Ann Palliat Med. doi:10.3978/j.issn.2224-5820, 2011.10.01
7. White NJ (2008) Qinghaosu (artemisinin): the price of success. Science 320:330-334
8. Sriram D, Rao VS, Chandrasekhara KV, Yogeeswari P (2004) Progress in the research of artemisinin and its analogues as antimalarials: an update. Nat Prod Res 18(6):503-527
9. Gomes MF, Faiz MA, Gyapong JO, Warsame M, Agbenyega T, Babiker A, Baiden F, Yunus EB, Binka F, Clerk C, Folb P, Hassan R, Hossain MA, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribeiro I, Samad R, White NJ, Study 13 Research Group (2009) Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet 373:557-566
10. Eastman RT, Fidock DA (2009) Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat Rev Microbiol 7:864-874
11. Hien TT, White NJ (1993) Qinghaosu. Lancet 341:603-608
12. Youns M, Efferth T, Reichling J, Fellenberg K, Bauer A, Hoheisel JD (2009) Gene expression profiling identifies novel key players involved in the cytotoxic effect of artesunate on pancreatic cancer cells. Biochem Pharmacol 78:273-283
13. Hou J, Wang D, Zhang R, Wang H (2008) Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 14:5519-5530
14. Li LN, Zhang HD, Yuan SJ, Yang DX, Wang L, Sun ZX (2008) Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin. Eur J Pharmacol 588:1-8
15. Nam W, Tak J, Ryu JK, Jung M, Yook JI, Kim HJ, Cha IH (2007) Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells. Head Neck 29:335-340
16. Wang MH, Zheng JS, Luo YP, Mi C (2008) Growth inhibition effects of artesunate on human cervical cancer cell line HeLa. Di 3 Jun Yi Da Xue Xue Bao 30:1730-1733
17. Rinner B, Siegl V, Pürstner P, Efferth T, Brem B, Greger H, Pfragner R (2004) Activity of novel plant extracts against medullary thyroid carcinoma cells. Anticancer Res 24:495-500
18. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446
19. Noedl H, Wongsrichanalai C, Miller RS, Myint KS, Looareesuwan S, Sukthana Y, Wongchotigul V, Kollaritsch H, Wiedermann G, Wernsdorfer WH (2002) Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II. Exp Parasitol 102:157-163
20. Xu H, He Y, Yang X, Liang L, Zhan Z, Ye Y, Yang X, Lian F, Sun L (2007) Anti-malarial agent artesunate inhibits TNF-alphainduced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology (Oxford) 46:920-926
21. Lee J, Zhou HJ, Wu XH (2006) Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells. Cancer Chemother Pharmacol 57:213-220
22. Lou XE, Zhou HJ (2001) Effects of artesunate on progestrone estrogen content and decidua in rats. Yao Xue Xue Bao 36:254-257
23. Buommino E, Baroni A, Canozo N, Petrazzuolo M, Nicoletti R, Vozza A, Tufano MA (2009) Artemisinin reduces human melanoma cell migration by down-regulating alpha V beta 3 integrin and reducing metalloproteinase 2 production. Invest New Drugs 27:412-418
24. Xiang P, Huang JT, Sa YL (2005) Culture and identification of rat marrow mesenchymal stem cells. J Bengbu Med Coll 30:1-3
25. Huang JT, Sa YL, Li HB, Liu AJ, Li HB (2003) Reformed method of feeder layer technique. Anat Res 25:78-79
26. Miyoshi T, Otsuka F, Otani H, Inagaki K, Goto J, Yamashita M, Ogura T, Iwasaki Y, Makino H (2008) Involvement of bone morphogenetic protein-4 in GH regulation by octreotide and bromocriptine in rat pituitary GH3 cells. J Endocrinol 197:159-169
27. Ren SG, Melmed S (2006) Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology 147:3936-3942
28. Chen T, Li M, Zhang R, Wang H (2009) Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy. J Cell Mol Med 13:1358-1370
29. Lu YY, Chen TS, Qu JL, Pan WL, Sun L, Wei XB (2009) Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells. J Biomed Sci 16:16
30. Singh NP, Panwar VK (2006) Case report of a pituitary macroadenoma treated with artemether. Integr Cancer Ther 5:391-394
31. Lai H, Singh NP (2006) Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)- induced breast cancer in the rat. Cancer Lett 231:43-48
32. Li S, Xue F, Cheng Z, Yang X, Wang S, Geng F, Pan L (2009) Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFkappaB p65. Int J Hematol 90:513-521
33. Li Z, Yuan SJ, Nie LP, Tian ZY, Xu LP, Han CM (2004) Apoptosis of tumor cells induced by artesunate is associated with suppressing survivin expression. Chin J Clin Pharmacol Ther 9:607-611
34. Mukae N, Enari M, Sakahira H, Fukuda Y, Inazawa J, Toh H, Nagata S (1998) Molecular cloning and characterization of human caspase-activated DNase. Proc Natl Acad Sci USA 95:9123-9128
35. Nicolier M, Decrion-Barthod AZ, Launay S, Prétet JL, Mougin C (2009) Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells. Biol Cell 101:455-467
36. Li K, Li Y, Shelton JM, Richardson JA, Spencer E, Chen ZJ, Wang X, Williams RS (2000) Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell 101:389-399
37. Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM, Mak TW (1998) Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94:739-750
38. Hsu SC, Yang JS, Kuo CL, Lo C, Lin JP, Hsia TC, Lin JJ, Lai KC, Kuo HM, Huang LJ, Kuo SC, Wood WG, Chung JG (2009) Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line. J Orthop Res 27:1637-1644
39. Tu HP, Chen YT, Chiu HC, Chin YT, Huang SM, Cheng LC, Fu E, Chiang CY (2009) Cyclosporine A enhances apoptosis in gingival keratinocytes of rats and in OECM1 cells via the mitochondrial pathway. J Periodontal Res 44:767-775
40. Feng B, Zhou XB, Yang X, Ye ZL, He ZY (2006) Apoptosis of hypertrophic cardiomyocytes stimulated by hypoxia-reoxygenation is partially mediated by apoptosis-inducing factor. Sheng Li Xue Bao 58:599-605
41. Tokuyama Y, Reddy AP, Bethea CL (2008) Neuroprotective actions of ovarian hormones without insult in the raphe region of rhesus macaques. Neuroscience 154:720-731
42. Miller M, Chen S, Woodliff J, Kansra S (2008) Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells. Endocrinology 149:4158-4167
43. Dang VH, Nguyen TH, Lee GS, Choi KC, Jeung EB (2009) In vitro exposure to xenoestrogens induces growth hormone transcription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells. Steroids 74:707-714