Neuroendocrine tumors secreting growth hormone-releasing hormone: Pathophysiological and clinical aspects

Pituitary

Volumn 9, Issue 3, 2006, Pages 221-229

  Gola, Monica ^a   Doga, Mauro ^a   Bonadonna, Stefania ^b   Mazziotti, Gherardo ^b   Vescovi, Pier Paolo ^a   Giustina, Andrea ^b  

^a CARLO POMA HOSPITAL   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Carcinoid tumors; Ectopic acromegaly; GHRH; Somatostatin analogs

Indexed keywords

CELL SURFACE RECEPTOR; GLUCOSE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; SOMATOMEDIN C; SOMATOSTATIN DERIVATIVE;

ACROMEGALY; ADRENAL CORTEX ADENOMA; CARCINOID; CELL STIMULATION; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DYSPNEA; ECHOGRAPHY; ENDOMETRIUM TUMOR; FLUSHING; GROWTH HORMONE RELEASE; GROWTH HORMONE SECRETING CELL; GROWTH INHIBITION; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HYPOPHYSECTOMY; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; IMMUNOREACTIVITY; LUNG SMALL CELL CANCER; MEDICAL DECISION MAKING; NEPHROLITHIASIS; NEUROENDOCRINE TUMOR; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS TUMOR; PATHOPHYSIOLOGY; PEPTIC ULCER; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; TREATMENT PLANNING; TUMOR GROWTH; WHEEZING;

ACROMEGALY; ADENOMA; ANIMALS; CARCINOID TUMOR; DIAGNOSIS, DIFFERENTIAL; GROWTH HORMONE-RELEASING HORMONE; GROWTH HORMONE-SECRETING PITUITARY ADENOMA; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; NEUROENDOCRINE TUMORS; PARANEOPLASTIC ENDOCRINE SYNDROMES; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 33750986529     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11102-006-0267-0     Document Type: Review

References (101)

1. Frohman LA, Jansson JO (1986) Growth Hormone-releasing hormone. Endocr Rev 7:223-253
2. Asa SL, Scheithauer BW, Bilbao JM et al (1984) A case for hypothalamic acromegaly: A clinopathological study of six patients with hypothalamic ganglyocitomas producing growth hormone releasing factor. J Clin Endocrinol Metab 58:796-803
3. Christofides ND, Stephanou A, Suzuki H et al (1984) Distribution of immunoreactive growth hormone-releasing hormone in the human brain and intestine and its production by tumors. J Clin Endocrinol Metab 59:747-751
4. Sasaki A, Sato S, Shigeru Y et al (1989) Multiple forms of immunoreactive growth hormone-releasing hormone in human plasma, hypothalamus, and tumor tissue. J Clin Endocrinol Metab 68:180-185
5. Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, Johanson A, Vale W, Horvath E, Kovacs K (1982) Somatotroph hyperplasia: Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest 70:965-977
6. Guillemin R, Brazeau P, Bohlen P et al (1982) Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 218:585-587
7. Thorner MO, Frohman LA, Leong DA et al (1984) Extrahypothalamic growth-hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: Plasma GRH levels in 177 acromegalic patients. J Clin Endocrinol Metab 59:846-849
8. Esch FS, Bohlen P, Ling NC et al (1982) Characterization of a 40 residue peptide from a human pancreatic tumor with growth hormone-releasing activity. Biochem Biophys Res Commun 109:152-158
9. Rivier J, Spiess J, Thorner M et al (1982) Characterization of a growth hormone-releasing factor from a human pancreatic islet tumor. Nature 300:276-278
10. Bloch B, Brazeau P, Ling N, Bohlen P, Esch F, Wehrenberg WB (1983) Immunohistochemical detection of growth hormone-releasing factor in brain. Nature 301:607-608
11. Merchenthaler I, Vigh S, Schally AV, Petrusz P (1984) Immunocytochemical localization of growth hormone-releasing factor in the rat hypothalamus. Endocrinology 114:1082-1085
12. Niimi M, Takahara J, Sato M, Kawanishi K (1990) Immunohistochemical identification of galanin and growth hormone-releasing factor containing neurons projecting to the median eminence in the rat. Neuroendocrinology 51:572-575
13. Epelbaum J, Moyse E, Tannenbaum GS, Kordon C, Beaudet A (1989) Combined autoradiographic and immunohistochemical evidence for an association of somatostatin binding sites with growth hormone-releasing factor containing nerve cell bodies in the rat arcuate nucleus. J Neuroendocrinol 1:109-115
14. Horvath S, Palkovits M, Gorcs T, Arimura A (1989) Electron microscopic immunocytochemical evidence for the existence of bidirectional synaptic connections between growth hormone- and somatostatin-containing neurons in the hypothalamus of the rat. Brain Res 481:8-15
15. Pellegrini E, Carmignac DF, Bluet-Pajot MT, Mounier F, Bennett P, Epelbaum J, Robinson IC (1997) Intrahypothalamic growth hormone feedback: From dwarfism to acromegaly in the rat. Endocrinology 138:4543-4551
16. Tannenbaum GS, Farhadi-Jou F, Beaudet A (1993) Ultradian oscillation in somatostatin binding in the arcuate nucleus of adult male rats. Endocrinology 133:1029-1034
17. Pellegrini E, Bluet-Pajot MT, Mounier F, Bennett P, Kordon C, Epelbaum J (1996) Central administration of a growth hormone (GH) receptor mRNA antisense increases GH pulsatility and decreases hypothalamic somatostatin expression in rats. J Neurosci 16:8140-8148
18. West CR, Lookingland KJ, Tucker HA (1997) Regulation of growth hormone releasing hormone and somatostatin from perifused, bovine hypothalamic slices. III. Reciprocal feedback between growth hormone-releasing hormone and somatostatin. Domest Anim Endocrinol 14:358-366
19. Saito H, Saito S, Ryuchi Y (1984) Clinical value of radioimmunoassay of plasma growth hormone releasing factor. Lancet 2:401-402
20. Delvalle J, Yamada T (1990) The gut as an endocrine organ. Ann Rev Med 41:447-455
21. Baird A, Wehrenberg WB, Bolhen P, Ling N (1985) Immunoreactive and biologically active growth hormone releasing factor in the rat placenta. Endocrinology 117:917-921
22. Giustina A, Bossoni S, Bodini C, Doga M, Girelli A, Buffoli MG, Schettino M, Wehrenberg WB (1991) The role of cholinergic tone in modulating the growth hormone response to growth hormone-releasing hormone in normal man. Metabolism 40:519-523
23. Frohman LA, Downs TR (1989) Human growth hormone-releasing hormone metabolism in vivo and in vitro. In: Casanueva FF, Dieguez C (eds) Recent Advances in Basic and Clinical Neuroendocrinology. Elsevier Science Publisher B.V., Amsterdam, pp 217-224
24. Barinaga M, Bilezikjian LM, Vale WW, Rosenfeld MG, Evans RM (1985) Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. Nature 314:279-281
25. Seifert H, Perrin M, Rivier J, Vale W (1985) Growth hormone-releasing factor binding sites in rat anterior pituitary membrane homogenates: modulation by glucocorticoids. Endocrinology 117:424-426
26. Barinaga M, Yamamoto G, Rivier G, Vale W, Evans R, Rosenfeld MG (1983) Transcriptional regulation of growth hormone gene expression by growth hormone-releasing factor. Nature 306:84-86
27. Mayo KE (1991) Molecular cloning and expression of a pituitary receptor for growth hormone-releasing hormone. Mol Endocrinol 6:1734-1744
28. Bilezikijan LM, Vale WW (1983) Stimulation of adenosine3,5-monophosphate production by growth hormone-releasing factors and its inhibition by somatostatin in anterior pituitary cells in vitro. Endocrinology 113:1726-1731
29. Natori S, Ikuyama S, Haji M, Ohashi M, Nawata H (1989) Growth hormone releasing hormone-sensitive adenylate cyclase activity in growth hormone producing pituitary adenoma: Correlation to the response of plasma growth hormone to growth hormone releasing hormone in patients with acromegaly. Endocrinol Jpn 36:229-236
30. Spiess J, Rivier J, Vale WW (1983) Characterization of rat hypothalamic growth hormone-releasing factor. Nature 303:532-535
31. Korytko A, Zeitler P, Cutler L (1996) Developmental regulation of pituitary GRF-receptor gene expression in the rat. Endocrinology 137:1326-1331
32. Bagnato A, Moretti C, Ohnishi J, Frajese G, Catt KJ (1992) Expression in the growth hormone-releasing hormone gene and its peptide product in the rat ovary. Endocrinology 130:1097-1102
33. Fujinaka Y, Yokogoshi Y, Zhang CY, Okura T, Kitagawa K, Saito S (1996) Tissue-specific molecular heterogeneity of human growth hormone-releasing hormone receptor protein. FEBS Lett 394:1-4
34. Fukata J, Diamond DJ, Martin JB (1985) Effects of rat growth hormone (rGH)-releasing factor and somatostatin on the release and synthesis of rGH in dispersed pituitary cells. Endocrinology 117:457-467
35. Stachura ME, Dhariwal APS, Frohman LA (1972) Growth hormone synthesis and release in vitro: Effects of partially purified ovine hypothalamic extract. Endocrinology 91: 1071-1078
36. Stachura ME (1976) Basal and dibutyryl cyclic AMP-stimulated release of newly synthesized and stored growth hormone from perfused rat pituitaries. Endocrinology 98:580-589
37. Stachura ME, Frohman LA (1975) Growth hormone: Independent release of big and small forms from rat pituitary in vitro. Science 187:447-449
38. Giustina A, Veldhuis JD (1998) Pathophysiology of the neuroregulation of growth hormone secretion in Experimental animals and the human. Endocr Rev 19:717-797
39. Giustina A, Bodini C, Bossoni S, Valentini U, Wehrenberg WB (1993) Variability in the growth hormone responses to growth hormone-releasing hormone alone or combined with pyridostigmine in type 1 diabetic patients. J Endocrinol Invest 6:585-590
40. Devesa J, Lima L, Lois N, Fraga C, Lechuga MJ, Arce V, Tresguerres JAF (1989) Reasons for the variability in growth hormone (GH) responses to GHRH challenge: The endogenous hypothalamic-somatotroph rhythm (HSR). Clin Endocrinol 30:367-377
41. Shibasaki T, Shizume K, Nakahara M, Masuda A, Jibiki K, Demura H, Wakabayashi I, Ling N (1984) Age-related changes in plasma growth hormone response to growth hormone-releasing factor in man. J Clin Endocrinol Metab 58:212-214
42. Gelato MC, Pescovitz OH, Cassorla F, Loriaux DL, Merriam GR (1984) Dose-response relationships for the effects of growth hormone releasing factor-(1-44)-NH2 in young adult men and women. J Clin Endocrinol Metab 59:197-201
43. Giustina A, Scalvini T, Tassi C, Desenzani P, Poiesi C, Wehrenberg WB, Rogol AD, Veldhuis JD (1997) Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone. J Clin Endocrinol Metab 82:1210-1219
44. Plotsky PM, Vale W (1985) Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230:461-463
45. Frohman LA, Downs TR, Clarke IJ, Thomas GB (1990) Measurement of growth hormone-releasing hormone and somatostatin in hypothalamicoportal plasma of unanesthetized sheep: Spontaneous secretion and response to insulin-induced hypoglycemia. J Clin Invest 86:17-24
46. Thomas GB, Cummins JT, Francis H, Sudbury AW, McCloud PI, Clarke IJ (1991) Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes. Endocrinology 128: 1151-1158
47. Cataldi M, Magnan E, Guillaume V et al (1994) Relationship between hypophyseal portal GHRH and somatostatin and peripheral GH levels in conscious sheep. J Endocrinol Invest 17:717-722
48. Dutour A, Briard N, Guillaume V, Magnan E, Cataldi M, Sauze N, Oliver C (1997) Another view of GH neuroregulation: Lessons from the sheep. Eur J Endocrinol 136:553-565
49. Bertherat J, Bluet-Pajot MT, Epelbaum J (1995) Neuroendocrine regulation of growth hormone. Eur J Endocrinol 132:12-24
50. Bilezikjian LM, Vale WV (1984) Chronic exposure of cultured rat anterior pituitary cells to GRF causes partial loss of responsiveness to GRF. Endocrinology 115:2032-2034
51. Ceda GP, Hoffman AR (1985) Growth hormone-releasing factor desensitization in rat anterior pituitary cells in vitro. Endocrinology 116:1334-1340
52. Davis IRE, Sheppard MC, Shakespeare RA, Lynch SS, Clayton RN (1986) Does growth hormone releasing factor desensitize the somatotroph? Interpretation of responses of growth hormone during and after 10-hour infusion of GRF 1-29 amide in man. Clin Endocrinol 24:135-140
53. Vance ML, Kaiser DI, Evans WS, Thorner MO (1985) Evidence for a limited growth hormone (GH)-releasing hormone (GHRH)-releasable quantity of GH: effects of 6-hour infusions on GH secretion in normal man. J Clin Endocrinol Metab 60:370-375
54. Jaffe CA, Turgeon DK, Friberg RD, Watkins PB, Barkan AL (1995) Nocturnal augmentation of growth hormone (GH) secretion is preserved during repetitive bolus administration of GH-releasing hormone: Potential involvement of endogenous somatostatin. J Clin Endocrinol Metab 80:3321-3326
55. Thorner MO, Vance ML, Hartman ML, Holl RW, Evans WS, Veldhuis JD, Van Cauter E, Copinschi G, Bowers CY (1990) Physiological role of somatostatin on growth hormone regulation in humans. Metabolism 39:40-42
56. Muller EE, Locatelli V, Cocchi D (1999) Neuroendocrine control of growth hormone secretion. Physiol Rev 79:511-607
57. Vance ML, Kaiser DL, Martha PM, Furlanetto R, Rivier J, Vale W, Thorner MO (1989) Lack of in vivo somatotroph densensitization or depletion after 14 days of continuous growth hormone (GH)-releasing hormone administration in normal men and a GH-deficient boy. J Clin Endocrinol Metab 68:22-28
58. Iranmanesh A, South S, Liem AY, Clemmons D, Thorner MO, Weltman A, Veldhuis JD (1998) Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotropic, IGF-1, and IGF-binding protein responses to a three-day intravenous growth-hormone-releasing hormone (GHRH) pulsatile infusion. Eur J Endocrinol 139:59-71
59. Giustina A, Schettino M, Bodini C et al (1992) Effect of Galanin on the growth hormone (GH) to GH-releasing hormone in acromegaly. Metabolism 41:1291-1294
60. Asa SL, Kovacs K, Stefaneanu L, Horvath E, Billestrup N, Gonzalez-Manchon C, Vale W (1990) Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone. Proc Soc Exp Biol Med 193:232-235
61. Melmed S, Casanueva FF, Cavagnini F, Chanson P, Frohman L, Grossman A, Ho K, Kleinberg D, Lamberts S, Laws E, Lombardi G, Vance ML, Werder KV, Wass J, Giustina A (2002) Acromegaly Treatment Consensus Workshop Participants. Guidelines for acromegaly management. J Clin Endocrinol Metab 87: 4054-4058
62. Spada A, Elahi FR, Arosio M, Sartorio A, Guglielmino L, Vallar L, Faglia G (1987) Lack of desensitization of adenomatous somatotrophs to growth-hormone releasing hormone in acromegaly. J Clin Endocrinol Metab 64:585-591
63. Thapar K, Kovacs K, Laws ER (1995) The classification and molecular biology of pituitary adenomas. Adv Tech Stand Neurosurg 22:4-53
64. Melmed S (1992) Etiology of pituitary acromegaly. Endocrinol Metab Clin North Am 21:539-551
65. Osamura RY, Oda K, Utsunomiya H et al (1993) Immunohistochemical expression of pit-1 protein in pituitary glands of human GRF transgenic mice: Its relationship with hormonal expressions. Endocr J 40:133-139
66. Lin SC, Lin CR, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld MG (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364:208-213
67. Lee EJ, Kotlar TJ, Ciric I, Lee MK, Lim SK, Lee HC, Huh KB, Mayo KE, Jameson JL (2001) Absence of constitutively activating mutations in the GHRH receptor in GH-producing pituitary tumors. J Clin Endocrinol Metab 86:3989-3995
68. Salvatori R, Thakker RV, Lopes MB, Fan X, Eswara JR, Ellison D, Lees P, Harding B, Yang I, Levine MA (2001) Absence of mutations in the growth hormone (GH)-releasing hormone receptor gene in GH-secreting pituitary adenomas. Clin Endocrinol (Oxf) 54:301-307
69. Moran A, Asa SL, Kovacs K et al (1990) Gigantism due to pituitary mammosomatotroph hyperplasia. N Engl J Med 323:322-327
70. Faglia G, Arosio M, Bazzoni N (1992) Ectopic acromegaly. Endocrinol Metab Clin North Am 21:575-595
71. Losa M, Schopohl J, von Werder K (1993) Ectopic secretion of growth hormone-releasing hormone in man. J Endocrinol Invest 16:69-81
72. Sonksen PH, Ayres AB, Braimbridge M et al (1976) Acromegaly caused by pulmonary carcinoid tumors. Clin Endocrinol 5:503-513
73. Frohman LA, Szabo M, Berelowitz M et al (1980) Partial purification and characterization of a peptide with GH releasing activity from extrapituitary tumors in agents with acromegaly. J Clin Invest 65:43-54
74. Scheithauer BW, Carpenter PC, Bloch B, Brazeau P (1984) Ectopic secretion of a growth hormone-secreting factor. Report of a case of acromegaly with bronchial carcinoid tumor. Am J Med 76:605-615
75. Athanassiadi K, Exarchos D, Tsagarakis S, Bellenis I (2004) Acromegaly caused by ectopic growth hormone-releasing hormone secretion by a carcinoid bronchial tumor: A rare entity. J Thorac Cardiovasc Surg 128:631-632
76. Altstadt TJ, Azzarelli B, Bevering C, Edmondson J, Nelson PB (2002) Acromegaly caused by a growth hormone-releasing hormone-secreting carcinoid tumor: Case report. Neurosurgery 50:1356-1359
77. Huber RM, Schopohl J, Losa M, Wolfram G, Thetter O, Permanetter W, Werder KV (1991) Growth-hormone releasing hormone in a bronchial carcinoid. Cancer 67:2538-2542
78. Oberg K, Norheim I, Wide L (1985) Serum growth hormone in patients with carcinoid tumors; basal levels and response to glucose and thyrotrophin releasing hormone. Acta Endocrinol 109:13-18
79. Sano T, Asa SL, Kovacs K (1988) Growth hormone-releasing hormone producing tumors: Clinical, biochemical, and morphological manifestations. Endocr Rev 9:357-373
80. Dayal Y, Lin HD, Tallberg K et al (1986) Immunocytochemical demonstration of growth hormone-releasing factor in gastrointestinal and pancreatic endocrine tumors. Am J Clin Pathol 85:13-20
81. Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Von Werder K, Melmed S (2000) Criteria for cure of acromegaly: A consensus statement. J Clin Endocrinol Metab 85:526-529
82. Doga M, Bonadonna S, Burattin A, Giustina A (2001) Ectopic secretion of growth-releasing hormone (GHRH) in neuroendocrine tumors: Relevant clinical aspects. Ann Oncol 12:S89-S94
83. Osella G, Orlandi F, Caraci P, Ventura M, Deandreis D, Papotti M, Bongiovanni M, Angeli A, Terolo M (2003) Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella. J Endocrinol Invest 26:163-169
84. Agha A, Farrell L, Downey P, Keeling P, Leen E, Sreenan S (2004) Acromegaly secondary to growth hormone releasing hormone secretion. Ir J Med Sci 173:215-216
85. Bonadonna S, Doga M, Gola M, Mazziotti G, Giustina A (2005) Diagnosis and treatment of acromegaly and its complications: Consensus guidelines. J Endocrinol Invest 28(Suppl):43-47
86. Zatelli MC, Maffei P, Piccin D, Martini C, Rea F, Rubello D, Margutti A, Culler MD, Sicolo N, degli Uberti EC (2005) Somatostatin Analogs in Vitro Effects in a Growth Hormone-Releasing Hormone-Secreting Bronchial Carcinoid. J Clin Endocrinol Metab 90:2104-2109
87. Kvols LK, Buck M (1987) Chemotherapy of endocrine malignancies: A review. Semin Oncol 14:343-353
88. Giustina A, Zaltieri G, Negrini F, Wehrenberg WB (1999) Pharmacological aspects of the treatment of acromegaly. Pharmacol Res 34:247-268
89. Melmed S, Casanueva F, Cavagnini F, Chanson P, Frohman LA, Gaillard R, Ghigo E, Ho K, Jaquet P, Kleinberg D, Lamberts S, Laws E, Lombardi G, Sheppard MC, Thorner M, Vance ML, Wass JA, Giustina A (2005) Consensus statement: Medical management of acromegaly. Eur J Endocrinol 153:737-740
90. Barkan AL, Shenker Y, Grekin RJ, Vale WW (1988) Acromegaly from ectopic growth hormone-releasing hormone secretion by a malignant carcinoid tumor: Successful treatment with long-acting somatostatin analogue SMS 201-995. Cancer 61: 221-226
91. Lamberts, SWJ, Krenning EP, Reubi J-C (1991) The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr Rev 12:450-482
92. Drange MR, Melmed S (1998) Long-acting lanreotide induces clinical and biochemical remission of acromegaly caused by disseminated growth hormone-releasing hormone-secreting carcinoid. J Clin Endocrinol Metab 83:3104-3109
93. Frohman LA (1984) Ectopic hormone production by tumors. Clin Neuroendocr Perspect 3:201-224
94. Giustina A, Casanueva FF, Cavagnini F, Chanson P, Clemmons D, Frohman LA, Gaillard R, Ho K, Jaquet P, Kleinberg DL, Lamberts SW, Lombardi G, Sheppard M, Strasburger CJ, Vance ML, Wass JA, Melmed S (2003) The Pituitary Society and the European Neuroendocrine Association. Diagnosis and treatment of acromegaly complications. J Endocrinol Invest 26:1242-1247
95. Christensen SE, Weeke J, Orskov H et al (1987) Continuous subcutaneous pump infusion of somatostatin analogue SMS 201-995 vs. subcutaneous injection schedule in acromegalic patients. Clin Endocrinol 27:297-306
96. Tauber JP, Babin TH, Tauber MT et al (1989) Long term effects of continuous subcutaneous infusion of the somatostatin analog octreotide in the treatment of acromegaly. J Clin Endocrinol Metab 68:917-924
97. Lefebvre S, De Paepe L, Abs R, Rahier J, Selvais P, Maiter D (1995) Subcutaneous octreotide treatment of a growth hormone-releasing hormone-secreting bronchial carcinoid: Superiority of continuous vs. intermittent administration to control hormonal secretion. Eur J Endocrinol 133:320-324
98. Moller DE, Moses AC, Jones K, Thorner MO, Vance ML (1989) Octreotide suppresses both growth hormone (GH) and GH-releasing hormone (GHRH) in acromegaly due to ectopic GHRH secretion. J Clin Endocrinol Metab 68:499-504
99. Chang JL, Anderson JV, Williams SJ, Carr DH, Bloom SR (1986) Remission of symptoms during long term treatment of metastatic pancreatic endocrine tumours with long acting somatostatin analogue. Br Med J 292:981-982
100. Zatelli MC, Piccin D, Tagliati F, Ambrosio MR, Margutti A, Padovani R, Scanarini M, Culler MD, degli Uberti EC (2003) Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: Effects on cell viability, GH, and PRL secretion. J Clin Endocrinol Metab 88:2797-2802
101. Saveanu A, Gunz G, Dufour H, Enjalbert A, Culler MD, Jaquet P (2003) Distribution and functionality of the somatostatin receptor subtypes in acromegaly. J Endocrinol Invest 26(Suppl 8):4-7