Expression and glucocorticoid-regulation of "Bam", a novel BH3-only transcript in acute lymphoblastic leukemia

Molecular Biology Reports

Volumn 39, Issue 5, 2012, Pages 6007-6013

  Mansha, Muhammad ^a   Wasim, Muhammad ^b   Kofler, Anita ^c   Ploner, Christian ^c  

^a UNIVERSITY OF EDUCATION   (Pakistan)

^b UNIVERSITY OF VETERINARY AND ANIMAL SCIENCES   (Pakistan)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Apoptosis; Bam; Cell cycle arrest; GC regulation; Glucocorticoids

Indexed keywords

BAM PROTEIN; BIM PROTEIN; GLUCOCORTICOID; MESSENGER RNA; TUMOR PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAM PROTEIN, HUMAN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN BCL 2;

3' UNTRANSLATED REGION; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; APOPTOSIS; ARTICLE; BAM GENE; BIM GENE; CELL CYCLE ARREST; CHILD; CHILD HEALTH; CLINICAL ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE INDUCTION; GENE LOCATION; GENE LOCUS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; TRANSCRIPTION REGULATION; TUMOR GENE; ALTERNATIVE RNA SPLICING; BIOLOGICAL MODEL; DRUG EFFECT; GENETICS; METABOLISM; REPRODUCIBILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, LEUKEMIC; GLUCOCORTICOIDS; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84863763400     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1414-x     Document Type: Article

References (29)

1. Pui CH, Relling MV, Downing JR (2004) Acute lymphoblastic leukemia. N Engl J Med 350:1535-1548
2. Cidlowski JA, King KL, Evans-Storms RB, Montague JW, Bortner CD, Hughes FM (1996) The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system. Recent Prog Horm Res 51:457-490
3. Ashwell JD, Lu FW, Vacchio MS (2000) Glucocorticoids in T cell development and function. Annu Rev Immunol 18:309-345
4. Pui CH, Robison LL, Look AT (2008) Acute lymphoblastic leukaemia. Lancet 71:1030-1043
5. Distelhorst CW (2002) Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ 9:6-19
6. Schaaf MJ, Cidlowski JA (2002) Molecular mechanisms of glucocorticoid action and resistance. J Steroid Biochem Mol Biol 83:37-48
7. Planey SL, Litwack G (2000) Glucocorticoid-induced apoptosis in lymphocytes. Biochem Biophys Res Commun 279:307-312
8. Haarman EG, Kaspers GJ, Veerman AJ (2003) Glucocorticoid resistance in childhood leukaemia: mechanisms and modulation. Br J Haematol 120:919-929
9. Laudet V, Gronemeyer H (2002) The nuclear receptor facts book. Academic Press, London, pp 1-462
10. Schmidt S, Rainer J, Riml S, Ploner C, Jesacher S, Achmuller C, Presul E, Skvortsov S, Crazzolar R, Fiegl M, Raivio T, Janne OA, Geley S, Meister B, Kofler R (2006) Identification of glucocorticoid- response genes in children with acute lymphoblastic leukemia. Blood 107:2061-2069
11. Geley S, Fiegl M, Hartmann BL, Kofler R (1996) Genes mediating glucocorticoid effects and mechanisms of their regulation. Rev Physiol Biochem Pharmacol 128:1-97
12. Tonko M, Ausserlechner MJ, Bernhard D, Helmberg A, Kofler R (2001) Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid- induced apoptosis. FASEB J 15:693-699
13. Planey SL, Abrams MT, Robertson NM, Litwack G (2003) Role of apical caspases and glucocorticoid-regulated genes in glucocorticoid- induced apoptosis of pre-B leukemic cells. Cancer Res 63:172-178
14. Wang Z, Malone MH, He H, McColl KS, Distelhorst CW (2003) Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoidinduced apoptosis. J Biol Chem 278:23861-23867
15. Hebbar PB, Archer TK (2003) Chromatin remodeling by nuclear receptors. Chromosoma 111:495-504
16. Schmidt S, Rainer J, Ploner C, Presul E, Riml S, Kofler R (2004) Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ 11(Suppl 1):S45-S55
17. Ploner C, Rainer J, Niederegger H, Eduardoff M, Villunger A, Geley S et al (2008) The BCL2 rheostat in glucocorticoidinduced apoptosis of acute lymphoblastic leukemia. Leukemia 22:370-377
18. Claudio JO, Masih-Khan E, Tang H, Goncalves J, Voralia M, Li ZH, Nadeem V, Cukerman E, Francisco-Pabalan O, Liew CC, Woodgett JR, Stewart AK (2002) A molecular compendium of genes expressed in multiple myeloma. Blood 100:2175-2186
19. Strasser-Wozak EMC, Hattmannstorfer R, Hála M, Hartmann BL, Fiegl M, Geley S, Kofler R (1995) Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoidinduced apoptosis in a human acute leukemic cell line. Cancer Res 55:348-353
20. Helmberg A, Auphan N, Caelles C, Karin M (1995) Glucocorticoid- induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J 14:452-460
21. Parson W, Kirchebner R, Mühlmann R, Renner K, Kofler A, Schmidt S, Kofler R (2005) Cancer cell line identification by short tandem repeat profiling: power and limitations. FASEB J 19:434-436
22. Mansha M, Carlet M, Ploner C, Gruber G, Wasim M, Wiegers GJ, Rainer J, Geley S, Kofler R (2010) Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia. Leuk Res 34:529-534
23. Abrams MT, Robertson NM, Yoon K, Wickstrom E (2004) Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA. J Biol Chem 279:55809-55817
24. Ploner C, Rainer J, Lobenwein S, Geley S, Kofler R (2009) Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells. Apoptosis 14:821-828
25. Adams JM, Cory S (2007) Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 19:488-496
26. Chipuk JE, Green DR (2008) How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 18:157-164
27. van Delft MF, Huang DCS (2006) How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res 16:203-213
28. O'Connor L, Strasser A, 'Reilly LAO, Hausmann G, Adams JM, Cory S, Huang DC (1998) Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17:384-395
29. Weber A, Paschen SA, Heger K, Wilfling F, Frankenberg T, Bauerschmitt H, Seiffert BM, Kirschnek S, Wagner H, Hacker G (2007) BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. J Cell Biol 177:625-636