Adaptive evolution of drug targets in producer and non-producer organisms

Biochemical Journal

Volumn 441, Issue 1, 2012, Pages 219-226

  Hansen, Bjarne G ^a,c   Sun, Xin E ^b,d   Genee, Hans J ^a   Kaas, Christian S ^a   Nielsen, Jakob B ^a   Mortensen, Uffe H ^a   Frisvad, Jens C ^a   Hedstrom, Lizbeth ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b BRANDEIS UNIVERSITY   (United States)

^c NOVOZYMES A S   (Denmark)

^d Boston University   (United States)

Author keywords

Drug resistance; Gene duplication; IMP dehydrogenase (IMPDH); Mycophenolic acid; Neofunctionalization; Penicillium

Indexed keywords

FUNGAL PROTEIN; MYCOPHENOLIC ACID; PENICILLIUM BREVICOMPACTUM IMP DEHYDROGENASE A; PENICILLIUM BREVICOMPACTUM IMP DEHYDROGENASE B; PENICILLIUM CHRYSOGENUM IMP DEHYDROGENASE A; PENICILLIUM CHRYSOGENUM IMP DEHYDROGENASE B; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; DRUG BINDING SITE; GENE DELETION; GENE DUPLICATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PENICILLIUM BREVICOMPACTUM; PENICILLIUM CHRYSOGENUM; PRIORITY JOURNAL;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SEQUENCE; BINDING SITES; BIOLOGICAL EVOLUTION; GENE DUPLICATION; GENE EXPRESSION REGULATION, FUNGAL; IMP DEHYDROGENASE; MODELS, MOLECULAR; MULTIGENE FAMILY; MYCOPHENOLIC ACID; PENICILLIUM; PROTEIN CONFORMATION;

EID: 84055223626     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111278     Document Type: Article

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