-
1
-
-
0017660871
-
Involvement of central GABA receptors in the regulation of blood pressure and heart rate of anesthetized cats
-
Antonaccio MJ, Taylor DG. Involvement of central GABA receptors in the regulation of blood pressure and heart rate of anesthetized cats. Eur J Pharmacol 46: 283-287, 1977.
-
(1977)
Eur J Pharmacol
, vol.46
, pp. 283-287
-
-
Antonaccio, M.J.1
Taylor, D.G.2
-
2
-
-
0026465673
-
Experimental atherosclerosis at the carotid bifurcation of the cynomolgus monkey. Localization, compensatory enlargement, and the sparing effect of lowered heart rate
-
Beere PA, Glagov S, Zarins CK. Experimental atherosclerosis at the carotid bifurcation of the cynomolgus monkey. Localization, compensatory enlargement, and the sparing effect of lowered heart rate. Arterioscler Thromb 12: 1245-1253, 1992.
-
(1992)
Arterioscler Thromb
, vol.12
, pp. 1245-1253
-
-
Beere, P.A.1
Glagov, S.2
Zarins, C.K.3
-
3
-
-
37049186663
-
Retarding effect of lowered heart rate on coronary atherosclerosis
-
Beere PA, Glagov S, Zarins CK. Retarding effect of lowered heart rate on coronary atherosclerosis. Science 226: 180-182, 1984.
-
(1984)
Science
, vol.226
, pp. 180-182
-
-
Beere, P.A.1
Glagov, S.2
Zarins, C.K.3
-
4
-
-
75649122259
-
A highresolution association mapping panel for the dissection of complex traits in mice
-
Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani LW, Kostem E, Furlotte N, Drake TA, Eskin E, Lusis AJ. A highresolution association mapping panel for the dissection of complex traits in mice. Genome Res 20: 281-290, 2010.
-
(2010)
Genome Res
, vol.20
, pp. 281-290
-
-
Bennett, B.J.1
Farber, C.R.2
Orozco, L.3
Kang, H.M.4
Ghazalpour, A.5
Siemers, N.6
Neubauer, M.7
Neuhaus, I.8
Yordanova, R.9
Guan, B.10
Truong, A.11
Yang, W.P.12
He, A.13
Kayne, P.14
Gargalovic, P.15
Kirchgessner, T.16
Pan, C.17
Castellani, L.W.18
Kostem, E.19
Furlotte, N.20
Drake, T.A.21
Eskin, E.22
Lusis, A.J.23
more..
-
5
-
-
60549086144
-
Blood pressure and heart rate QTL in mice of the B6/D2 lineage: Sex differences and environmental influences
-
Blizard DA, Lionikas A, Vandenbergh DJ, Vasilopoulos T, Gerhard GS, Griffith JW, Klein LC, Stout JT, Mack HA, Lakoski JM, Larsson L, Spicer JM, Vogler GP, McClearn GE. Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics 36: 158-166, 2009.
-
(2009)
Physiol Genomics
, vol.36
, pp. 158-166
-
-
Blizard, D.A.1
Lionikas, A.2
Vandenbergh, D.J.3
Vasilopoulos, T.4
Gerhard, G.S.5
Griffith, J.W.6
Klein, L.C.7
Stout, J.T.8
Mack, H.A.9
Lakoski, J.M.10
Larsson, L.11
Spicer, J.M.12
Vogler, G.P.13
McClearn, G.E.14
-
6
-
-
77955754932
-
Strain-dependent variation in collateral circulatory function in mouse hindlimb
-
Chalothorn D, Faber JE. Strain-dependent variation in collateral circulatory function in mouse hindlimb. Physiol Genomics 42: 469-479, 2010.
-
(2010)
Physiol Genomics
, vol.42
, pp. 469-479
-
-
Chalothorn, D.1
Faber, J.E.2
-
7
-
-
3843146548
-
Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice
-
DiPetrillo K, Tsaih SW, Sheehan S, Johns C, Kelmenson P, Gavras H, Churchill GA, Paigen B. Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol Genomics 17: 215-220, 2004.
-
(2004)
Physiol Genomics
, vol.17
, pp. 215-220
-
-
DiPetrillo, K.1
Tsaih, S.W.2
Sheehan, S.3
Johns, C.4
Kelmenson, P.5
Gavras, H.6
Churchill, G.A.7
Paigen, B.8
-
8
-
-
41149133900
-
A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia
-
Dokun AO, Keum S, Hazarika S, Li Y, Lamonte GM, Wheeler F, Marchuk DA, Annex BH. A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. Circulation 117: 1207-1215, 2008.
-
(2008)
Circulation
, vol.117
, pp. 1207-1215
-
-
Dokun, A.O.1
Keum, S.2
Hazarika, S.3
Li, Y.4
Lamonte, G.M.5
Wheeler, F.6
Marchuk, D.A.7
Annex, B.H.8
-
9
-
-
77956512209
-
Genome-wide association analysis identifies multiple loci related to resting heart rate
-
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PI, Muller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dorr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJ, Estrada K, Hwang SJ, Bis JC, Ruckert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Volzke H, Campbell H, Meitinger T, Uda M, Witteman JC, Psaty BM, Wichmann HE, Harris TB, Kaab S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BH, Boerwinkle E, O'Donnell CJ. Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet 19: 3885-3894, 2010.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3885-3894
-
-
Eijgelsheim, M.1
Newton-Cheh, C.2
Sotoodehnia, N.3
de Bakker, P.I.4
Muller, M.5
Morrison, A.C.6
Smith, A.V.7
Isaacs, A.8
Sanna, S.9
Dorr, M.10
Navarro, P.11
Fuchsberger, C.12
Nolte, I.M.13
de Geus, E.J.14
Estrada, K.15
Hwang, S.J.16
Bis, J.C.17
Ruckert, I.M.18
Alonso, A.19
Launer, L.J.20
Hottenga, J.J.21
Rivadeneira, F.22
Noseworthy, P.A.23
Rice, K.M.24
Perz, S.25
Arking, D.E.26
Spector, T.D.27
Kors, J.A.28
Aulchenko, Y.S.29
Tarasov, K.V.30
Homuth, G.31
Wild, S.H.32
Marroni, F.33
Gieger, C.34
Licht, C.M.35
Prineas, R.J.36
Hofman, A.37
Rotter, J.I.38
Hicks, A.A.39
Ernst, F.40
Najjar, S.S.41
Wright, A.F.42
Peters, A.43
Fox, E.R.44
Oostra, B.A.45
Kroemer, H.K.46
Couper, D.47
Volzke, H.48
Campbell, H.49
Meitinger, T.50
Uda, M.51
Witteman, J.C.52
Psaty, B.M.53
Wichmann, H.E.54
Harris, T.B.55
Kaab, S.56
Siscovick, D.S.57
Jamshidi, Y.58
Uitterlinden, A.G.59
Folsom, A.R.60
Larson, M.G.61
Wilson, J.F.62
Penninx, B.W.63
Snieder, H.64
Pramstaller, P.P.65
van Duijn, C.M.66
Lakatta, E.G.67
Felix, S.B.68
Gudnason, V.69
Pfeufer, A.70
Heckbert, S.R.71
Stricker, B.H.72
Boerwinkle, E.73
O'Donnell, C.J.74
more..
-
10
-
-
0032797221
-
Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The Insulin Resistance Atherosclerosis Study (IRAS)
-
Festa A, D'Agostino R Jr, Rautaharju P, O'Leary DH, Rewers M, Mykkanen L, Haffner SM. Is QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The Insulin Resistance Atherosclerosis Study (IRAS). Stroke 30: 1566-1571, 1999.
-
(1999)
Stroke
, vol.30
, pp. 1566-1571
-
-
Festa, A.1
D'Agostino Jr., R.2
Rautaharju, P.3
O'Leary, D.H.4
Rewers, M.5
Mykkanen, L.6
Haffner, S.M.7
-
11
-
-
15944376562
-
Strategies for mapping and cloning quantitative trait genes in rodents
-
Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 6: 271-286, 2005.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 271-286
-
-
Flint, J.1
Valdar, W.2
Shifman, S.3
Mott, R.4
-
12
-
-
27844486634
-
Genomic analysis of metabolic pathway gene expression in mice
-
Ghazalpour A, Doss S, Sheth SS, Ingram-Drake LA, Schadt EE, Lusis AJ, Drake TA. Genomic analysis of metabolic pathway gene expression in mice. Genome Biol 6: R59, 2005.
-
(2005)
Genome Biol
, vol.6
-
-
Ghazalpour, A.1
Doss, S.2
Sheth, S.S.3
Ingram-Drake, L.A.4
Schadt, E.E.5
Lusis, A.J.6
Drake, T.A.7
-
13
-
-
77957736114
-
Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat
-
Hildreth CM, Goodchild AK. Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat. BMC Neurosci 11: 128, 2010.
-
(2010)
BMC Neurosci
, vol.11
, pp. 128
-
-
Hildreth, C.M.1
Goodchild, A.K.2
-
14
-
-
49849089701
-
The genetic contribution to heart rate and heart rate variability in quiescent mice
-
Howden R, Liu E, Miller-DeGraff L, Keener HL, Walker C, Clark JA, Myers PH, Rouse DC, Wiltshire T, Kleeberger SR. The genetic contribution to heart rate and heart rate variability in quiescent mice. Am J Physiol Heart Circ Physiol 295: H59-H68, 2008.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Howden, R.1
Liu, E.2
Miller-DeGraff, L.3
Keener, H.L.4
Walker, C.5
Clark, J.A.6
Myers, P.H.7
Rouse, D.C.8
Wiltshire, T.9
Kleeberger, S.R.10
-
15
-
-
9844221411
-
Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10
-
Julier C, Delepine M, Keavney B, Terwilliger J, Davis S, Weeks DE, Bui T, Jeunemaitre X, Velho G, Froguel P, Ratcliffe P, Corvol P, Soubrier F, Lathrop GM. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum Mol Genet 6: 2077-2085, 1997.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 2077-2085
-
-
Julier, C.1
Delepine, M.2
Keavney, B.3
Terwilliger, J.4
Davis, S.5
Weeks, D.E.6
Bui, T.7
Jeunemaitre, X.8
Velho, G.9
Froguel, P.10
Ratcliffe, P.11
Corvol, P.12
Soubrier, F.13
Lathrop, G.M.14
-
16
-
-
45149105926
-
Efficient control of population structure in model organism association mapping
-
Kang HM, Zaitlen NA, Wade CM, Kirby A, Heckerman D, Daly MJ, Eskin E. Efficient control of population structure in model organism association mapping. Genetics 178: 1709-1723, 2008.
-
(2008)
Genetics
, vol.178
, pp. 1709-1723
-
-
Kang, H.M.1
Zaitlen, N.A.2
Wade, C.M.3
Kirby, A.4
Heckerman, D.5
Daly, M.J.6
Eskin, E.7
-
17
-
-
33746318124
-
Long-term prognostic value of resting heart rate in subjects with prehypertension
-
King DE, Everett CJ, Mainous AG 3rd, Liszka HA. Long-term prognostic value of resting heart rate in subjects with prehypertension. Am J Hypertens 19: 796-800, 2006.
-
(2006)
Am J Hypertens
, vol.19
, pp. 796-800
-
-
King, D.E.1
Everett, C.J.2
Mainous III, A.G.3
Liszka, H.A.4
-
18
-
-
0346122781
-
Flow-induced vascular remodeling in the mouse: A model for carotid intima-media thickening
-
Korshunov VA, Berk BC. Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening. Arterioscler Thromb Vasc Biol 23: 2185-2191, 2003.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 2185-2191
-
-
Korshunov, V.A.1
Berk, B.C.2
-
19
-
-
58849136602
-
Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid
-
Korshunov VA, Berk BC. Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid. Arterioscler Thromb Vasc Biol 29: 47-53, 2009.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 47-53
-
-
Korshunov, V.A.1
Berk, B.C.2
-
20
-
-
3142727721
-
Strain-dependent vascular remodeling: The "Glagov phenomenon" is genetically determined
-
Korshunov VA, Berk BC. Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined. Circulation 110: 220-226, 2004.
-
(2004)
Circulation
, vol.110
, pp. 220-226
-
-
Korshunov, V.A.1
Berk, B.C.2
-
21
-
-
60549111634
-
WGCNA: An R package for weighted correlation network analysis
-
Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformat 9: 559, 2008.
-
(2008)
BMC Bioinformat
, vol.9
, pp. 559
-
-
Langfelder, P.1
Horvath, S.2
-
22
-
-
77951487868
-
Cardiovascular risk prediction: Basic concepts, current status, and future directions
-
Lloyd-Jones DM. Cardiovascular risk prediction: basic concepts, current status, and future directions. Circulation 121: 1768-1777, 2010.
-
(2010)
Circulation
, vol.121
, pp. 1768-1777
-
-
Lloyd-Jones, D.M.1
-
23
-
-
19244386918
-
Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21
-
Mansfield TA, Simon DB, Farfel Z, Bia M, Tucci JR, Lebel M, Gutkin M, Vialettes B, Christofilis MA, Kauppinen-Makelin R, Mayan H, Risch N, Lifton RP. Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet 16: 202-205, 1997.
-
(1997)
Nat Genet
, vol.16
, pp. 202-205
-
-
Mansfield, T.A.1
Simon, D.B.2
Farfel, Z.3
Bia, M.4
Tucci, J.R.5
Lebel, M.6
Gutkin, M.7
Vialettes, B.8
Christofilis, M.A.9
Kauppinen-Makelin, R.10
Mayan, H.11
Risch, N.12
Lifton, R.P.13
-
24
-
-
2342648224
-
Major quantitative trait locus for resting heart rate maps to a region on chromosome 4
-
Martin LJ, Comuzzie AG, Sonnenberg GE, Myklebust J, James R, Marks J, Blangero J, Kissebah AH. Major quantitative trait locus for resting heart rate maps to a region on chromosome 4. Hypertension 43: 1146-1151, 2004.
-
(2004)
Hypertension
, vol.43
, pp. 1146-1151
-
-
Martin, L.J.1
Comuzzie, A.G.2
Sonnenberg, G.E.3
Myklebust, J.4
James, R.5
Marks, J.6
Blangero, J.7
Kissebah, A.H.8
-
25
-
-
77956102449
-
Bivariate genetic association of KIAA1797 with heart rate in American Indians: The Strong Heart Family Study
-
Melton PE, Rutherford S, Voruganti VS, Goring HH, Laston S, Haack K, Comuzzie AG, Dyer TD, Johnson MP, Kent JW Jr, Curran JE, Moses EK, Blangero J, Barac A, Lee ET, Best LG, Fabsitz RR, Devereux RB, Okin PM, Bella JN, Broeckel U, Howard BV, MacCluer JW, Cole SA, Almasy L. Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. Hum Mol Genet 19: 3662-3671, 2010.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3662-3671
-
-
Melton, P.E.1
Rutherford, S.2
Voruganti, V.S.3
Goring, H.H.4
Laston, S.5
Haack, K.6
Comuzzie, A.G.7
Dyer, T.D.8
Johnson, M.P.9
Kent Jr., J.W.10
Curran, J.E.11
Moses, E.K.12
Blangero, J.13
Barac, A.14
Lee, E.T.15
Best, L.G.16
Fabsitz, R.R.17
Devereux, R.B.18
Okin, P.M.19
Bella, J.N.20
Broeckel, U.21
Howard, B.V.22
MacCluer, J.W.23
Cole, S.A.24
Almasy, L.25
more..
-
26
-
-
67650118795
-
Elevated heart rate in cardiovascular diseases: A target for treatment
-
Palatini P. Elevated heart rate in cardiovascular diseases: a target for treatment? Prog Cardiovasc Dis 52: 46-60, 2009.
-
(2009)
Prog Cardiovasc Dis
, vol.52
, pp. 46-60
-
-
Palatini, P.1
-
27
-
-
0032420191
-
The structures of the human neuronal nicotinic acetylcholine receptor beta2-and alpha3-subunit genes (CHRNB2 and CHRNA3)
-
Rempel N, Heyers S, Engels H, Sleegers E, Steinlein OK. The structures of the human neuronal nicotinic acetylcholine receptor beta2-and alpha3-subunit genes (CHRNB2 and CHRNA3). Hum Genet 103: 645-653, 1998.
-
(1998)
Hum Genet
, vol.103
, pp. 645-653
-
-
Rempel, N.1
Heyers, S.2
Engels, H.3
Sleegers, E.4
Steinlein, O.K.5
-
28
-
-
79551577310
-
Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse
-
Scicluna BP, Tanck MW, Remme CA, Beekman L, Coronel R, Wilde AA, Bezzina CR. Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse. J Mol Cell Cardiol 50: 380-389, 2011.
-
(2011)
J Mol Cell Cardiol
, vol.50
, pp. 380-389
-
-
Scicluna, B.P.1
Tanck, M.W.2
Remme, C.A.3
Beekman, L.4
Coronel, R.5
Wilde, A.A.6
Bezzina, C.R.7
-
29
-
-
85090878417
-
LDheatmap: An R function for graphical display of pairwise linkage disequilibria between single nucleotide polymorphisms
-
Shin JH, Blay S, McNeney B, Graham J. LDheatmap: an R function for graphical display of pairwise linkage disequilibria between single nucleotide polymorphisms. J Stat Softw 16: 1-9, 2006.
-
(2006)
J Stat Softw
, vol.16
, pp. 1-9
-
-
Shin, J.H.1
Blay, S.2
McNeney, B.3
Graham, J.4
-
30
-
-
36849075872
-
Genome scan linkage results for heart rate variability (the Framingham Heart Study). Am J Cardiol 90: 1290-1293, 2002. 30a. Spielmann N, Leon AS, Rao DC, Rice T, Skinner JS, Rankinen T, Bouchard C. Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
-
Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Corey D, Levy D. Genome scan linkage results for heart rate variability (the Framingham Heart Study). Am J Cardiol 90: 1290-1293, 2002. 30a. Spielmann N, Leon AS, Rao DC, Rice T, Skinner JS, Rankinen T, Bouchard C. Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study. Am J Physiol Heart Circ Physiol 293: H3366-H3371, 2007.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
-
-
Singh, J.P.1
Larson, M.G.2
O'Donnell, C.J.3
Tsuji, H.4
Corey, D.5
Levy, D.6
-
31
-
-
0032524643
-
Removal of GABAergic inhibition in the mediodorsal nucleus of the rat thalamus leads to increases in heart rate and blood pressure
-
Stotz-Potter E, Benarroch E. Removal of GABAergic inhibition in the mediodorsal nucleus of the rat thalamus leads to increases in heart rate and blood pressure. Neurosci Lett 247: 127-130, 1998.
-
(1998)
Neurosci Lett
, vol.247
, pp. 127-130
-
-
Stotz-Potter, E.1
Benarroch, E.2
-
32
-
-
0037067391
-
QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice
-
Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B. QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics 10: 5-12, 2002.
-
(2002)
Physiol Genomics
, vol.10
, pp. 5-12
-
-
Sugiyama, F.1
Churchill, G.A.2
Li, R.3
Libby, L.J.4
Carver, T.5
Yagami, K.6
John, S.W.7
Paigen, B.8
-
33
-
-
0036163615
-
GABA and GABA receptors in the central nervous system and other organs
-
Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol 213: 1-47, 2002.
-
(2002)
Int Rev Cytol
, vol.213
, pp. 1-47
-
-
Watanabe, M.1
Maemura, K.2
Kanbara, K.3
Tamayama, T.4
Hayasaki, H.5
-
34
-
-
0038178996
-
GABA-A receptor subtypes in the brain: A paradigm for CNS drug discovery
-
Whiting PJ. GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery? Drug Discov Today 8: 445-450, 2003.
-
(2003)
Drug Discov Today
, vol.8
, pp. 445-450
-
-
Whiting, P.J.1
-
35
-
-
0346502280
-
Mapping blood pressure loci in (A/J X B6)F2 mice
-
Woo DD, Kurtz I. Mapping blood pressure loci in (A/J X B6)F2 mice. Physiol Genomics 15: 236-242, 2003.
-
(2003)
Physiol Genomics
, vol.15
, pp. 236-242
-
-
Woo, D.D.1
Kurtz, I.2
|