Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 29, Issue 1, 2009, Pages 47-53

  Korshunov, Vyacheslav A ^a,b   Berk, Bradford C ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

C3heb FeJ; Genetics; Intima; Low blood flow; Mouse; SJL J

Indexed keywords

ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTERY OCCLUSION; ARTICLE; BLOOD FLOW; C3H MOUSE; CARDIOVASCULAR DISEASE; CAROTID ARTERY; CHROMOSOME 11; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 2; CHROMOSOME 7; COMMON CAROTID ARTERY; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; GENOME; HAPLOTYPE MAP; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE; SWISS JAMES LAMBERT MOUSE; ANIMAL; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; CHROMOSOME; CHROMOSOME 12; CHROMOSOME MAP; CROSS BREEDING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTIMA; MOUSE STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; TUNICA MEDIA;

ANIMALS; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; CAROTID ARTERIES; CAROTID ARTERY, COMMON; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, MAMMALIAN; CROSSES, GENETIC; GENE EXPRESSION REGULATION; GENOME; HUMANS; LOD SCORE; MICE; MICE, INBRED C3H; MICE, INBRED STRAINS; QUANTITATIVE TRAIT LOCI; TUNICA INTIMA; TUNICA MEDIA;

EID: 58849136602     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.108.178111     Document Type: Article

References (27)

1. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340:14-22.
2. Fox CS, Polak JF, Chazaro I, Cupples A, Wolf PA, D'Agostino RA, O'Donnell CJ. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham heart study. Stroke. 2003;34:397-401.
3. Fox CS, Cupples LA, Chazaro I, Polak JF, Wolf PA, D'Agostino RB, Ordovas JM, O'Donnell CJ. Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. Am J Hum Genet. 2004;74:253-261.
4. Schwartz SM, deBlois D, O'Brien ER. The intima. Soil for atherosclerosis and restenosis. Circ Res. 1995;77:445-465.
5. Nestor AL, Cicila GT, Karol SE, Langenderfer KM, Hollopeter SL, Allison DC. Linkage analysis of neointimal hyperplasia and vascular wall transformation after balloon angioplasty. Physiol Genomics. 2006;25:286-293.
6. Li Q, Li Y, Zhang Z, Gilbert TR, Matsumoto AH, Dobrin SE, Shi W. Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Stroke. 2008;39:166-173.
7. Wang X, Paigen B. Genome-wide search for new genes controlling plasma lipid concentrations in mice and humans. Curr Opin Lipidol. 2005;16:127-137.
8. Carallo C, Irace C, Pujia A, De Franceschi MS, Crescenzo A, Motti C, Cortese C, Mattioli PL, Gnasso A. Evaluation of common carotid hemodynamic forces. Relations with wall thickening. Hypertension. 1999;34:217-221.
9. Stone PH, Coskun AU, Kinlay S, Clark ME, Sonka M, Wahle A, Ilegbusi OJ, Yeghiazarians Y, Popma JJ, Orav J, Kuntz RE, Feldman CL. Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans. In vivo 6-month follow-up study. Circulation. 2003;108:438-444.
10. Korshunov VA, Berk BC. Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined. Circulation. 2004;110:220-226.
11. Harmon KJ, Couper LL, Lindner V. Strain-dependent vascular remodeling phenotypes in inbred mice. Am J Pathol. 2000;156:1741-1748.
12. Korshunov VA, Nikonenko TA, Tkachuk VA, Brooks A, Berk BC. Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening. Arterioscler Thromb Vasc Biol. 2006;26:295-300.
13. Chen C, Korshunov VA, Massett MP, Yan C, Berk BC. Impaired Vasorelaxation in Inbred Mice Is Associated with Alterations in Both Nitric Oxide and Super Oxide Pathways. J Vasc Res. 2007;44:504-512.
14. Korshunov VA, Berk BC. Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening. Arterioscler Thromb Vasc Biol. 2003;23:2185-2191.
15. Doerge RW, Churchill GA. Permutation tests for multiple loci affecting a quantitative character. Genetics. 1996;142:285-294.
16. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11:241-247.
17. Healy DA, Zierler RE, Nicholls SC, Clowes AW, Primozich JF, Bergelin RO, Strandness DE Jr. Long-term follow-up and clinical outcome of carotid restenosis. J Vasc Surg. 1989;10:662-668, discussion 668-669.
18. Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJ, Krams R, de Crom R. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation. 2006;113:2744-2753.
19. Dokun AO, Keum S, Hazarika S, Li Y, Lamonte GM, Wheeler F, Marchuk DA, Annex BH. A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. Circulation. 2008;117:1207-1215.
20. Stone PH, Coskun AU, Kinlay S, Popma JJ, Sonka M, Wahle A, Yeghi-azarians Y, Maynard C, Kuntz RE, Feldman CL. Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study. Eur Heart J. 2007;28:705-710.
21. O'Donnell CJ, Cupples LA, D'Agostino RB, Fox CS, Hoffmann U, Hwang SJ, Ingellson E, Liu C, Murabito JM, Polak JF, Wolf PA, Demissie S. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. BMC Med Genet. 2007;8 Suppl 1:S4.
22. Ishida M, Ishida T, Thomas S, Berk BC. Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells. Circ Res. 1998;82:7-12.
23. Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A. The human Mis 12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol. 2006;173:9-17.
24. Jabbour L, Welter JF, Kollar J, Hering TM. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene-evidence for a role in apoptosis. Genomics. 2003;81:292-303.
25. Bundschu K, Walter U, Schuh K. Getting a first clue about SPRED functions. Bioessays. 2007;29:897-907.
26. Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A. Spred is a Sprouty-related suppressor of Ras signalling. Nature. 2001;412:647-651.
27. Wesselman JP, Kuijs R, Hermans JJ, Janssen GM, Fazzi GE, Van Essen H, Evelo CT, Struijker-Boudier HA, De Mey JG. Role of the Rhoa/Rho kinase system in flow-related remodeling of rat mesenteric small arteries in vivo. J Vasc Res. 2004;41:277-290.