Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures

Epilepsia

Volumn 53, Issue 7, 2012, Pages 1245-1253

  Airaksinen, Antti M ^a   Hekmatyar, Shahryar K ^b,d   Jerome, Neil ^b   Niskanen, Juha Pekka ^a   Huttunen, Joanna K ^a   Pitkänen, Asla ^a,c   Kauppinen, Risto A ^b,e   Gröhn, Olli H ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF GEORGIA   (United States)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Animal model; Electrophysiology; Epilepsy; Functional imaging

Indexed keywords

KAINIC ACID; MEDETOMIDINE;

ANIMAL EXPERIMENT; AROUSAL; ARTICLE; BOLD SIGNAL; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; ELECTRIC POTENTIAL; ELECTRODE; EPILEPTIC STATE; EVOKED RESPONSE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMODYNAMICS; HIPPOCAMPUS; LOCAL FIELD POTENTIAL; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RAT; SEDATION; SEIZURE; SIGNAL PROCESSING;

ACTION POTENTIALS; ANIMALS; BRAIN; BRAIN MAPPING; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; IMAGE PROCESSING, COMPUTER-ASSISTED; KAINIC ACID; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN; RATS; RATS, WISTAR; SEIZURES; WAKEFULNESS;

EID: 84863723459     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2012.03539.x     Document Type: Article

References (42)

1. Airaksinen AM, Niskanen JP, Chamberlain R, Huttunen JK, Nissinen J, Garwood M, Pitkanen A, Grohn O,. (2010) Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence. Magn Reson Med 64: 1191-1199.
2. Angenstein F, Kammerer E, Niessen HG, Frey JU, Scheich H, Frey S,. (2007) Frequency-dependent activation pattern in the rat hippocampus, a simultaneous electrophysiological and fMRI study. Neuroimage 38: 150-163. (Pubitemid 47429993)
3. Austin VC, Blamire AM, Allers KA, Sharp T, Styles P, Matthews PM, Sibson NR,. (2005) Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia. Neuroimage 24: 92-100. (Pubitemid 39611029)
4. Bari F, Horvath G, Benedek G,. (1993) Dexmedetomidine-induced decrease in cerebral blood flow is attenuated by verapamil in rats: a laser Doppler study. Can J Anaesth 40: 748-754. (Pubitemid 23278495)
5. Begec Z, Toprak HI, Demirbilek S, Erdil F, Onal D, Ersoy MO,. (2008) Dexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure duration. Acta Anaesthesiol Scand 52: 302-306.
6. Blumenfeld H,. (2007) Functional MRI studies of animal models in epilepsy. Epilepsia 48 (Suppl. 4): 18-26. (Pubitemid 47340745)
7. Canals S, Beyerlein M, Murayama Y, Logothetis NK,. (2008) Electric stimulation fMRI of the perforant pathway to the rat hippocampus. Magn Reson Imaging 26: 978-986.
8. DeSalvo MN, Schridde U, Mishra AM, Motelow JE, Purcaro MJ, Danielson N, Bai X, Hyder F, Blumenfeld H,. (2010) Focal BOLD fMRI changes in bicuculline-induced tonic-clonic seizures in the rat. Neuroimage 50: 902-909.
9. Duong TQ,. (2007) Cerebral blood flow and BOLD fMRI responses to hypoxia in awake and anesthetized rats. Brain Res 1135: 186-194. (Pubitemid 46188429)
10. Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, Blumenfeld H,. (2008) Remote effects of focal hippocampal seizures on the rat neocortex. J Neurosci 28: 9066-9081.
11. Englot DJ, Modi B, Mishra AM, DeSalvo M, Hyder F, Blumenfeld H,. (2009) Cortical deactivation induced by subcortical network dysfunction in limbic seizures. J Neurosci 29: 13006-13018.
12. Friston KJ, Ashburner JT, Kiebel SJ, Nichols TE, Penny WD,. (2007) Statistical parametric mapping: the analysis of functional brain images. Academic Press, London, U.K.
13. Goddard GV, McIntyre DC, Leech CK,. (1969) A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 25: 295-330.
14. Huttunen JK, Grohn O, Penttonen M,. (2008) Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex. Neuroimage 39: 775-785. (Pubitemid 350117626)
15. Kobayashi E, Hawco CS, Grova C, Dubeau F, Gotman J,. (2006) Widespread and intense BOLD changes during brief focal electrographic seizures. Neurology 66: 1049-1055. (Pubitemid 44044790)
16. Lemieux L, Krakow K, Fish DR,. (2001) Comparison of spike-triggered functional MRI BOLD activation and EEG dipole model localization. Neuroimage 14: 1097-1104. (Pubitemid 33049851)
17. Mirsattari SM, Ives JR, Bihari F, Leung LS, Menon RS, Bartha R,. (2005) Real-time display of artifact-free electroencephalography during functional magnetic resonance imaging and magnetic resonance spectroscopy in an animal model of epilepsy. Magn Reson Med 53: 456-464. (Pubitemid 40171060)
18. Mirsattari SM, Ives JR, Leung LS, Menon RS,. (2007) EEG monitoring during functional MRI in animal models. Epilepsia 48 (Suppl. 4): 37-46. (Pubitemid 47340747)
19. Mirski MA, Rossell LA, McPherson RW, Traystman RJ,. (1994) Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. Anesthesiology 81: 1422-1428. (Pubitemid 24381434)
20. Moeller F, Tyvaert L, Nguyen DK, LeVan P, Bouthillier A, Kobayashi E, Tampieri D, Dubeau F, Gotman J,. (2009) EEG-fMRI: adding to standard evaluations of patients with nonlesional frontal lobe epilepsy. Neurology 73: 2023-2030.
21. Nersesyan H, Hyder F, Rothman DL, Blumenfeld H,. (2004) Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats. J Cereb Blood Flow Metab 24: 589-599. (Pubitemid 38725363)
22. Ogawa S, Lee TM, Kay AR, Tank DW,. (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87: 9868-9872. (Pubitemid 120016545)
23. Olney JW, Rhee V, Ho OL,. (1974) Kainic acid: a powerful neurotoxic analogue of glutamate. Brain Res 77: 507-512.
24. Pawela CP, Biswal BB, Cho YR, Kao DS, Li R, Jones SR, Schulte ML, Matloub HS, Hudetz AG, Hyde JS,. (2008) Resting-state functional connectivity of the rat brain. Magn Reson Med 59: 1021-1029. (Pubitemid 351590515)
25. Pawela CP, Biswal BB, Hudetz AG, Schulte ML, Li R, Jones SR, Cho YR, Matloub HS, Hyde JS,. (2009) A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity. Neuroimage 46: 1137-1147.
26. Peeters RR, Tindemans I, De Schutter E, Van der Linden A,. (2001) Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation. Magn Reson Imaging 19: 821-826. (Pubitemid 32845949)
27. Prielipp RC, Wall MH, Tobin JR, Groban L, Cannon MA, Fahey FH, Gage HD, Stump DA, James RL, Bennett J, Butterworth J,. (2002) Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow. Anesth Analg 95: 1052-1059.
28. Rojas MJ, Navas JA, Rector DM,. (2006) Evoked response potential markers for anesthetic and behavioral states. Am J Physiol Regul Integr Comp Physiol 291: R189-R196.
29. Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F, Blumenfeld H,. (2008) Negative BOLD with large increases in neuronal activity. Cereb Cortex 18: 1814-1827. (Pubitemid 352019902)
30. Silva AC, Koretsky AP, Duyn JH,. (2007) Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex. Magn Reson Med 57: 1110-1118. (Pubitemid 46911295)
31. Sinclair MD,. (2003) A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice. Can Vet J 44: 885-897. (Pubitemid 37527346)
32. Talke P, Stapelfeldt C, Garcia P,. (2007) Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. J Neurosurg Anesthesiol 19: 195-199. (Pubitemid 47012358)
33. Tenney JR, Duong TQ, King JA, Ludwig R, Ferris CF,. (2003) Corticothalamic modulation during absence seizures in rats: a functional MRI assessment. Epilepsia 44: 1133-1140. (Pubitemid 37100037)
34. Tenney JR, Duong TQ, King JA, Ferris CF,. (2004) FMRI of brain activation in a genetic rat model of absence seizures. Epilepsia 45: 576-582. (Pubitemid 38802203)
35. Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L,. (1983) Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 9: 315-335. (Pubitemid 13002328)
36. Van Camp N, D'Hooge R, Verhoye M, Peeters RR, De Deyn PP, Van der Linden A,. (2003) Simultaneous electroencephalographic recording and functional magnetic resonance imaging during pentylenetetrazol-induced seizures in rat. Neuroimage 19: 627-636. (Pubitemid 36926275)
37. Weber R, Ramos-Cabrer P, Wiedermann D, van Camp N, Hoehn M,. (2006) A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat. Neuroimage 29: 1303-1310. (Pubitemid 43184193)
38. Whittington RA, Virag L, Vulliemoz Y, Cooper TB, Morishima HO,. (2002) Dexmedetomidine increases the cocaine seizure threshold in rats. Anesthesiology 97: 693-700. (Pubitemid 34977330)
39. Zhang X, Le Gal La Salle G, Ridoux V, Yu PH, Ju G,. (1997) Prevention of kainic acid-induced limbic seizures and fos expression by the GABA-A receptor agonist muscimol. Eur J Neurosci 9: 29-40. (Pubitemid 27083472)
40. Zhao F, Zhao T, Zhou L, Wu Q, Hu X,. (2008) BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat. Neuroimage 39: 248-260. (Pubitemid 350102202)
41. Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS,. (2007) EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain 130: 2343-2353. (Pubitemid 47327625)
42. Zornow MH, Fleischer JE, Scheller MS, Nakakimura K, Drummond JC,. (1990) Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog. Anesth Analg 70: 624-630. (Pubitemid 20384196)