Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy

Journal of Neurosurgical Anesthesiology

Volumn 19, Issue 3, 2007, Pages 195-199

  Talke, Pekka ^a   Stapelfeldt, Claudia ^a   Garcia, Paul ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2 agonist; Epilepsy; Seizure; Surgery

Indexed keywords

DEXMEDETOMIDINE;

ADJUVANT THERAPY; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAM; EPILEPTIC DISCHARGE; EPILEPTIC FOCUS; FEMALE; HEMISPHERE; HEMODYNAMICS; HUMAN; INFORMED CONSENT; INTRACTABLE EPILEPSY; LOADING DRUG DOSE; MALE; NEUROSURGERY; PATIENT MONITORING; PRIORITY JOURNAL; SEDATION; STATISTICAL SIGNIFICANCE; TREATMENT INDICATION; VIDEORECORDING;

ADULT; ANALGESICS, NON-NARCOTIC; BLOOD PRESSURE; DEXMEDETOMIDINE; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; HEART RATE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MONITORING, PHYSIOLOGIC; TIME FACTORS; VIDEO RECORDING;

EID: 34347327135     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/ANA.0b013e318060d281     Document Type: Article

References (14)

1. Talke PO. Dexmedetomidine. Drugs. 2000;59:269-270.
2. Ebert TJ, Hall JE, Barney JA, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000;93:382-394.
3. Talke PO, Tong C, Lee HW, et al. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesth Analg. 1997;85:358-364.
4. Bekker AY, Kaufman B, Samir H, et al. The use of dexmedetomidine infusion for awake craniotomy. Anesth Analg. 2001;92:1251-1253.
5. Souter MJ, Rozet I, Ojemann JG, et al. Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography. J Neurosurg Anesthesiol. 2007;19:38-44.
6. Kirchberger K, Schmitt H, Hummel C, et al. Clonidine and methohexital-induced epileptic magnetoencephalographic discharges in patients with focal epilepsies. Epilepsia. 1998;39:841-849.
7. Kettenmann B, Feichtinger M, Tilz C, et al. Comparison of clonidine to sleep deprivation in the potential to induce spike or sharp-wave activity. Clin Neurophysiol. 2005;116:905-912.
8. Schmitt H, Druschky K, Hummel C, et al. Detection of an epileptic mirror focus after oral application of clonidine. Br J Anaesth. 1999;83:349-951.
9. Miyazaki Y, Adachi T, Kurata J, et al. Dexmedetomidine reduces seizure threshold during enflurane anaesthesia in cats. Br J Anaesth. 1999;82:935-937.
10. Mirski MA, Rossell LA, McPherson RW, et al. Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. Anesthesiology. 1994;81:1422-1428.
11. Whittington RA, Virag L, Vulliemoz Y, et al. Dexmedetomidine increases the cocaine seizure threshold in rats. Anesthesiology. 2002;97:693-700.
12. Tanaka K, Oda Y, Funao T, et al. Dexmedetomidine decreases the convulsive potency of bupivacaine and levobupivacaine in rats: involvement of alpha2-adrenoceptor for controlling convulsions. Anesth Analg. 2005;100:687-696.
13. Halonen T, Kotti T, Tuunanen J, et al. Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. Brain Res. 1995;693:217-224.
14. Nelson LE, Lu J, Guo T, et al. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003;98:428-436.