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Volumn 133, Issue 3, 2012, Pages 821-830

Beyond taxanes: The next generation of microtubule-targeting agents

Author keywords

Epothilones; Eribulin; Ixabepilone; Microtubule targeting agents; Taxanes

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; EPOTHILONE B; EPOTHILONE DERIVATIVE; ERIBULIN; GEMCITABINE; INDIBULIN; ISPINESIB; IXABEPILONE; LAPATINIB; MICROTUBULE TARGETING AGENT; NAVELBINE; PACLITAXEL; SAGOPILONE; TAXANE DERIVATIVE; TESETAXEL; TRASTUZUMAB; UNCLASSIFIED DRUG; VINFLUNINE;

EID: 84863720339     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1875-6     Document Type: Review
Times cited : (40)

References (66)
  • 1
    • 70249083437 scopus 로고    scopus 로고
    • First-line chemotherapy for met-astatic breast cancer
    • Telli ML, Carlson RW (2009) First-line chemotherapy for met-astatic breast cancer. Clin Breast Cancer 9(suppl 2):S66-S72
    • (2009) Clin Breast Cancer , vol.9 , Issue.SUPPL. 2
    • Telli, M.L.1    Carlson, R.W.2
  • 2
    • 79952945610 scopus 로고    scopus 로고
    • Surveillance epidemiology and end results Accessed 4 Nov 2010
    • Surveillance epidemiology and end results. SEER stat fact sheets: breast. http://seer.cancer.gov/statfacts/html/breast.html#survival. Accessed 4 Nov 2010
    • SEER Stat Fact Sheets: Breast
  • 3
    • 77954335786 scopus 로고    scopus 로고
    • Locally recurrent or metastatic breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Cardoso F, Senkus-Konefka E, Fallowfield L, Costa A, Casti-glione M (2010) Locally recurrent or metastatic breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(suppl 5):v15-v19
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Cardoso, F.1    Senkus-Konefka, E.2    Fallowfield, L.3    Costa, A.4    Casti-Glione, M.5
  • 4
    • 60549107977 scopus 로고    scopus 로고
    • Activity of ixabepilone in patients with metastatic breast cancer with primary resistance to taxanes
    • Yardley DA (2008) Activity of ixabepilone in patients with metastatic breast cancer with primary resistance to taxanes. Clin Breast Cancer 8(6):487-492
    • (2008) Clin Breast Cancer , vol.8 , Issue.6 , pp. 487-492
    • Yardley, D.A.1
  • 5
    • 67049133438 scopus 로고    scopus 로고
    • Treatment options for breast cancer resistant to anthracyclines and taxane
    • Moreno-Aspitia A, Perez EA (2009) Treatment options for breast cancer resistant to anthracyclines and taxane. Mayo Clin Proc 84(6):533-545
    • (2009) Mayo Clin Proc , vol.84 , Issue.6 , pp. 533-545
    • Moreno-Aspitia, A.1    Perez, E.A.2
  • 6
    • 79151478071 scopus 로고    scopus 로고
    • TM
    • National comprehensive cancer network Accessed 4 Nov 2010
    • TM. Breast cancer. V.3.2010. http://www. nccn.org. Accessed 4 Nov 2010
    • (2010) Breast Cancer , vol.3
  • 7
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, Dickler M, Cobleigh M, Perez EA et al (2007) Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357(26):2666-2676
    • (2007) N Engl J Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3    Dickler, M.4    Cobleigh, M.5    Perez, E.A.6
  • 8
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, Cortes J, Pivot X, Tomczak P et al (2010) Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 28(20):3239-3247
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3    Cortes, J.4    Pivot, X.5    Tomczak, P.6
  • 9
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bev-acizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Dieras V, Glaspy J, Brufsky A, Bondarenko I, Lipatov O et al (2011) RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bev-acizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 29(10):1252-1260
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1252-1260
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3    Brufsky, A.4    Bondarenko, I.5    Lipatov, O.6
  • 10
    • 71549143528 scopus 로고    scopus 로고
    • Detecting an overall survival benefit that is derived from progression-free survival
    • Broglio KR, Berry DA (2009) Detecting an overall survival benefit that is derived from progression-free survival. J Natl Cancer Inst 101(23):1642-1649
    • (2009) J Natl Cancer Inst , vol.101 , Issue.23 , pp. 1642-1649
    • Broglio, K.R.1    Berry, D.A.2
  • 12
    • 38449097524 scopus 로고    scopus 로고
    • Mechanisms of multidrug resistance: The potential role of microtubule-stabilizing agents
    • Fojo T, Menefee M (2007) Mechanisms of multidrug resistance: the potential role of microtubule-stabilizing agents. Ann Oncol 18(suppl 5):v3-v8
    • (2007) Ann Oncol , vol.18 , Issue.SUPPL. 5
    • Fojo, T.1    Menefee, M.2
  • 13
    • 41849106072 scopus 로고    scopus 로고
    • Cellular mechanisms of resistance to anthracyclines and taxanes in cancer: Intrinsic and acquired
    • Chien AJ, Moasser MM (2008) Cellular mechanisms of resistance to anthracyclines and taxanes in cancer: intrinsic and acquired. Sem Oncol 35(suppl 2):S1-S14
    • (2008) Sem Oncol , vol.35 , Issue.SUPPL. 2
    • Chien, A.J.1    Moasser, M.M.2
  • 14
    • 0345874561 scopus 로고    scopus 로고
    • Class III b-tubulin isotype: A key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology
    • Katsetos CD, Legido A, Perentes E, Mork SJ (2003) Class III b-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology. J Child Neurol 18(12):851-866
    • (2003) J Child Neurol , vol.18 , Issue.12 , pp. 851-866
    • Katsetos, C.D.1    Legido, A.2    Perentes, E.3    Mork, S.J.4
  • 15
    • 16844365749 scopus 로고    scopus 로고
    • BIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability
    • Kamath K, Wilson L, Cabral F, Jordan MA (2005) bIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability. J Biol Chem 280(13): 12902-12907
    • (2005) J Biol Chem , vol.280 , Issue.13 , pp. 12902-12907
    • Kamath, K.1    Wilson, L.2    Cabral, F.3    Jordan, M.A.4
  • 16
    • 33745593252 scopus 로고    scopus 로고
    • The bI/bIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studies
    • Magnani M, Ortuso F, Soro S, Alcaro S, Tramontano A, Botta M (2006) The bI/bIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studies. FEBS J 273(14):3301-3310
    • (2006) FEBS J , vol.273 , Issue.14 , pp. 3301-3310
    • Magnani, M.1    Ortuso, F.2    Soro, S.3    Alcaro, S.4    Tramontano, A.5    Botta, M.6
  • 17
    • 30344455579 scopus 로고    scopus 로고
    • Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer
    • Paradiso A, Mangia A, Chiriatti A, Tommasi S, Zito A, Latorre A et al (2005) Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer. Ann Oncol 16(suppl 4):iv14-iv19
    • (2005) Ann Oncol , vol.16 , Issue.SUPPL. 4
    • Paradiso, A.1    Mangia, A.2    Chiriatti, A.3    Tommasi, S.4    Zito, A.5    Latorre, A.6
  • 18
    • 34147187180 scopus 로고    scopus 로고
    • Cytoskeleton and paclitaxel sensitivity in breast cancer: The role of b-tubulins
    • Tommasi S, Mangia A, Lacalamita R, Bellizzi A, Fedele V, Chiriatti A et al (2007) Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of b-tubulins. Int J Cancer 120(10):2078-2085
    • (2007) Int J Cancer , vol.120 , Issue.10 , pp. 2078-2085
    • Tommasi, S.1    Mangia, A.2    Lacalamita, R.3    Bellizzi, A.4    Fedele, V.5    Chiriatti, A.6
  • 19
    • 0030018666 scopus 로고    scopus 로고
    • Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties
    • Gerth K, Bedorf N, Hofle G, Irschik H, Reichenbach H (1996) Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J Antibiot (Tokyo) 49(6): 560-563
    • (1996) J Antibiot (Tokyo) , vol.49 , Issue.6 , pp. 560-563
    • Gerth, K.1    Bedorf, N.2    Hofle, G.3    Irschik, H.4    Reichenbach, H.5
  • 20
    • 58749113261 scopus 로고    scopus 로고
    • Clinical development of ix-abepilone and other epothilones in patients with advanced solid tumors
    • Rivera E, Lee J, Davies A (2008) Clinical development of ix-abepilone and other epothilones in patients with advanced solid tumors. Oncologist 13(12):1207-1223
    • (2008) Oncologist , vol.13 , Issue.12 , pp. 1207-1223
    • Rivera, E.1    Lee, J.2    Davies, A.3
  • 21
    • 43549095495 scopus 로고    scopus 로고
    • Ixabepilone: A novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms
    • Vahdat L (2008) Ixabepilone: a novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms. Oncologist 13(3):214-221
    • (2008) Oncologist , vol.13 , Issue.3 , pp. 214-221
    • Vahdat, L.1
  • 22
    • 34247170561 scopus 로고    scopus 로고
    • The Pat-21 breast cancer model derived from a patient with primary Taxol resistance recapitulates the phenotype of its origin, has altered beta-tubulin expression, and is sensitive to ixabepilone
    • abstract LB-280
    • Jordan M, Miller H, Ni L, Castenada S, Inigo I, Kan D et al. (2006) The Pat-21 breast cancer model derived from a patient with primary Taxol resistance recapitulates the phenotype of its origin, has altered beta-tubulin expression, and is sensitive to ixabepilone. Proc Am Assoc Cancer Res 47:abstract LB-280
    • (2006) Proc Am Assoc Cancer Res , vol.47
    • Jordan, M.1    Miller, H.2    Ni, L.3    Castenada, S.4    Inigo, I.5    Kan, D.6
  • 24
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • Lee FY, Borzilleri R, Fairchild CR, Kim SH, Long BH, Reven-tos-Suarez C et al (2001) BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 7(5):1429-1437
    • (2001) Clin Cancer Res , vol.7 , Issue.5 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3    Kim, S.H.4    Long, B.H.5    Reven-Tos-Suarez, C.6
  • 25
    • 36849056385 scopus 로고    scopus 로고
    • Preclinical efficacy evaluation of ixabepilone (BMS-247550) in combination with cetuximab or capecitabine in human colon and lung carcinoma xenografts
    • abstract 12017
    • Lee FY, Camuso A, Castaneda S, Flefleh C, Ingio I, Kan D et al. (2006) Preclinical efficacy evaluation of ixabepilone (BMS-247550) in combination with cetuximab or capecitabine in human colon and lung carcinoma xenografts. J Clin Oncol 24(sup-pl):abstract 12017
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Lee, F.Y.1    Camuso, A.2    Castaneda, S.3    Flefleh, C.4    Ingio, I.5    Kan, D.6
  • 26
    • 58149331055 scopus 로고    scopus 로고
    • Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models
    • Lee FYF, Covello KL, Castaneda S, Hawken DR, Kan D, Lewin A et al (2008) Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models. Clin Cancer Res 14(24):8123-8131
    • (2008) Clin Cancer Res , vol.14 , Issue.24 , pp. 8123-8131
    • Lee, F.Y.F.1    Covello, K.L.2    Castaneda, S.3    Hawken, D.R.4    Kan, D.5    Lewin, A.6
  • 27
    • 34548157209 scopus 로고    scopus 로고
    • Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane and capecitabine
    • Perez EA, Lerzo G, Pivot X, Thomas E, Vahdat L, Bosserman L et al (2007) Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane and capecitabine. J Clin Oncol 25(23):3407-3414
    • (2007) J Clin Oncol , vol.25 , Issue.23 , pp. 3407-3414
    • Perez, E.A.1    Lerzo, G.2    Pivot, X.3    Thomas, E.4    Vahdat, L.5    Bosserman, L.6
  • 28
    • 34548187738 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer
    • Thomas E, Tabernero J, Fornier M, Conte P, Fumoleau P, Lluch A et al (2007) Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J Clin Oncol 25(23):3399-3406
    • (2007) J Clin Oncol , vol.25 , Issue.23 , pp. 3399-3406
    • Thomas, E.1    Tabernero, J.2    Fornier, M.3    Conte, P.4    Fumoleau, P.5    Lluch, A.6
  • 29
    • 34548179878 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy
    • Roche H, Yelle L, Cognetti F, Mauriac L, Bunnell C, Sparano J et al (2007) Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy. J Clin Oncol 25(23):3415-3420
    • (2007) J Clin Oncol , vol.25 , Issue.23 , pp. 3415-3420
    • Roche, H.1    Yelle, L.2    Cognetti, F.3    Mauriac, L.4    Bunnell, C.5    Sparano, J.6
  • 30
    • 21044441003 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer
    • Low JA, Wedam SB, Lee JJ, Berman AW, Brufsky A, Yang SX et al (2005) Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J Clin Oncol 23(12):2726-2734
    • (2005) J Clin Oncol , vol.23 , Issue.12 , pp. 2726-2734
    • Low, J.A.1    Wedam, S.B.2    Lee, J.J.3    Berman, A.W.4    Brufsky, A.5    Yang, S.X.6
  • 31
    • 34548169630 scopus 로고    scopus 로고
    • Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes
    • Denduluri N, Low JA, Lee JJ, Berman AW, Walshe JM, Vatas U et al (2007) Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes. J Clin Oncol 25(23):3421-3427
    • (2007) J Clin Oncol , vol.25 , Issue.23 , pp. 3421-3427
    • Denduluri, N.1    Low, J.A.2    Lee, J.J.3    Berman, A.W.4    Walshe, J.M.5    Vatas, U.6
  • 32
    • 36849071808 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
    • Thomas E, Gomez HL, Li RK, Chung HC, Fein LE, Chan VF et al (2007) Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol 25(33):5210-5217
    • (2007) J Clin Oncol , vol.25 , Issue.33 , pp. 5210-5217
    • Thomas, E.1    Gomez, H.L.2    Li, R.K.3    Chung, H.C.4    Fein, L.E.5    Chan, V.F.6
  • 33
    • 77955448465 scopus 로고    scopus 로고
    • Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes
    • Hortobagyi GN, Gomez HL, Li RK, Chung HC, Fein LE, Chan VF et al (2010) Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes. Breast Cancer Res Treat 122(2):409-418
    • (2010) Breast Cancer Res Treat , vol.122 , Issue.2 , pp. 409-418
    • Hortobagyi, G.N.1    Gomez, H.L.2    Li, R.K.3    Chung, H.C.4    Fein, L.E.5    Chan, V.F.6
  • 34
    • 77954752064 scopus 로고    scopus 로고
    • Randomized phase III trial of ixabepilone plus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Sparano JA, Vrdoljak E, Rixe O, Xu B, Manikhas A, Medina C et al (2010) Randomized phase III trial of ixabepilone plus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 28(20):3256-3263
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3256-3263
    • Sparano, J.A.1    Vrdoljak, E.2    Rixe, O.3    Xu, B.4    Manikhas, A.5    Medina, C.6
  • 35
    • 72149108389 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine improves overall survival in symptomatic patients with metastatic breast cancer previously treated with anthracycline and taxane in 2 large phase III studies
    • abstract 6114
    • Conte P, Roche H, Perez E, Sparano J, Xu B, Jassem J et al. (2009) Ixabepilone plus capecitabine improves overall survival in symptomatic patients with metastatic breast cancer previously treated with anthracycline and taxane in 2 large phase III studies. Cancer Res 69(suppl):abstract 6114
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Conte, P.1    Roche, H.2    Perez, E.3    Sparano, J.4    Xu, B.5    Jassem, J.6
  • 36
    • 77953025896 scopus 로고    scopus 로고
    • Efficacy of ixab-epilone in ER/PR/HER2-negative (triple-negative) breast cancer
    • Perez EA, Patel T, Moreno-Aspitia A (2010) Efficacy of ixab-epilone in ER/PR/HER2-negative (triple-negative) breast cancer. Breast Cancer Res Treat 121(2):261-271
    • (2010) Breast Cancer Res Treat , vol.121 , Issue.2 , pp. 261-271
    • Perez, E.A.1    Patel, T.2    Moreno-Aspitia, A.3
  • 37
    • 79251530503 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine in metastatic breast cancer patients with reduced performance status previously treated with anthracyclines and taxanes: A pooled analysis by performance status of efficacy and safety data from 2 phase III studies
    • Roche H, Conte P, Perez EA, Sparano JA, Xu B, Jassem J et al (2011) Ixabepilone plus capecitabine in metastatic breast cancer patients with reduced performance status previously treated with anthracyclines and taxanes: a pooled analysis by performance status of efficacy and safety data from 2 phase III studies. Breast Cancer Res Treat 125(3):755-765
    • (2011) Breast Cancer Res Treat , vol.125 , Issue.3 , pp. 755-765
    • Roche, H.1    Conte, P.2    Perez, E.A.3    Sparano, J.A.4    Xu, B.5    Jassem, J.6
  • 38
    • 67049142413 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine vs capecitabine in patients with triple-negative tumors: A pooled analysis of patients from two large phase III clinical studies
    • abstract 3057
    • Rugo HS, Roche H, Thomas E, Blackwell K, Chung HC, Lerzo G et al. (2009) Ixabepilone plus capecitabine vs capecitabine in patients with triple-negative tumors: a pooled analysis of patients from two large phase III clinical studies. Cancer Res 69(sup-pl):abstract 3057
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Rugo, H.S.1    Roche, H.2    Thomas, E.3    Blackwell, K.4    Chung, H.C.5    Lerzo, G.6
  • 39
    • 76949103841 scopus 로고    scopus 로고
    • Visceral disease in patients with metastatic breast cancer: Efficacy and safety of treatment with ixabepilone and other chemotherapeutic agents
    • Yardley DA (2010) Visceral disease in patients with metastatic breast cancer: efficacy and safety of treatment with ixabepilone and other chemotherapeutic agents. Clin Breast Cancer 10(1):64-71
    • (2010) Clin Breast Cancer , vol.10 , Issue.1 , pp. 64-71
    • Yardley, D.A.1
  • 40
    • 74849122823 scopus 로고    scopus 로고
    • A phase II trial of trastuzumab plus weekly ixabepilone and carboplatin in patients with HER2-positive metastatic breast cancer: An eastern cooperative oncology group trial
    • Moulder S, Li H, Gradishar WJ, Gradishar WJ, Perez EA, Sparano JA et al (2010) A phase II trial of trastuzumab plus weekly ixabepilone and carboplatin in patients with HER2-positive metastatic breast cancer: an eastern cooperative oncology group trial. Breast Cancer Res Treat 119(3):663-667
    • (2010) Breast Cancer Res Treat , vol.119 , Issue.3 , pp. 663-667
    • Moulder, S.1    Li, H.2    Gradishar, W.J.3    Gradishar, W.J.4    Perez, E.A.5    Sparano, J.A.6
  • 41
    • 77957148050 scopus 로고    scopus 로고
    • Phase i trial of ixabepilone plus pegylated liposomal doxorubicin in patients with adenocarcinoma of breast or ovary
    • Chuang E, Wiener N, Christos P, Kessler R, Cobham M, Donovan D et al (2010) Phase I trial of ixabepilone plus pegylated liposomal doxorubicin in patients with adenocarcinoma of breast or ovary. Ann Oncol 21(10):2075-2080
    • (2010) Ann Oncol , vol.21 , Issue.10 , pp. 2075-2080
    • Chuang, E.1    Wiener, N.2    Christos, P.3    Kessler, R.4    Cobham, M.5    Donovan, D.6
  • 42
    • 74549220028 scopus 로고    scopus 로고
    • Phase Ib study of ixabepilone (I) in combination with epirubicin (E) in women with metastatic breast cancer
    • abstract 1058
    • Roche H, Zambetti M, Dalenc F, Govi S, Gladieff L, Mudenda B et al. (2008) Phase Ib study of ixabepilone (I) in combination with epirubicin (E) in women with metastatic breast cancer. J Clin Oncol 26(suppl):abstract 1058
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Roche, H.1    Zambetti, M.2    Dalenc, F.3    Govi, S.4    Gladieff, L.5    Mudenda, B.6
  • 43
    • 79952836195 scopus 로고    scopus 로고
    • Randomized phase II study of weekly versus every 3 week ixabepilone plus bevacizumab (ixa/bev) versus paclitaxel plus bev (pac/bev) as first-line therapy for metastatic breast cancer (MBC): Final results
    • abstract 1040
    • Rugo HS, Campone M, Amadori D, Wardley AM, Aldrighetti D, Conte PF et al. (2010) Randomized phase II study of weekly versus every 3 week ixabepilone plus bevacizumab (ixa/bev) versus paclitaxel plus bev (pac/bev) as first-line therapy for metastatic breast cancer (MBC): final results. J Clin Oncol 28(suppl):abstract 1040
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Rugo, H.S.1    Campone, M.2    Amadori, D.3    Wardley, A.M.4    Aldrighetti, D.5    Conte, P.F.6
  • 44
    • 71249103102 scopus 로고    scopus 로고
    • Novel microtubule-targeting agents-the epothilones
    • Cheng KL, Bradley T, Budman DR (2008) Novel microtubule-targeting agents-the epothilones. Biologics 2(4):789-811
    • (2008) Biologics , vol.2 , Issue.4 , pp. 789-811
    • Cheng, K.L.1    Bradley, T.2    Budman, D.R.3
  • 45
    • 58749100031 scopus 로고    scopus 로고
    • Phase II trial of patupilone in patients with breast cancer brain metastases (BCBM) progressing or recurring after whole brain radiation therapy (WBXRT
    • abstract 1086
    • Conlin AK, D'Andrea G, Hudis CA, Robson ME, Drullinsky P, Theodoulou M et al. (2008) Phase II trial of patupilone in patients with breast cancer brain metastases (BCBM) progressing or recurring after whole brain radiation therapy (WBXRT). J Clin Oncol 26(suppl):abstract 1086
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Conlin, A.K.1    D'Andrea, G.2    Hudis, C.A.3    Robson, M.E.4    Drullinsky, P.5    Theodoulou, M.6
  • 46
    • 79952118633 scopus 로고    scopus 로고
    • Phase II study evaluating the efficacy and safety of sagopilone (ZK-EPO) in patients with metastatic breast cancer that has progressed following chemotherapy
    • Morrow PK, Divers S, Provencher L, Luoh SW, Petrella TM, Giurescu M et al (2010) Phase II study evaluating the efficacy and safety of sagopilone (ZK-EPO) in patients with metastatic breast cancer that has progressed following chemotherapy. Breast Cancer Res Treat 123(3):837-842
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.3 , pp. 837-842
    • Morrow, P.K.1    Divers, S.2    Provencher, L.3    Luoh, S.W.4    Petrella, T.M.5    Giurescu, M.6
  • 47
    • 77952686784 scopus 로고    scopus 로고
    • Eribulin mesylate for the treatment of breast cancer
    • Cigler T, Vahdat LT (2010) Eribulin mesylate for the treatment of breast cancer. Expert Opin Pharmacother 11(9):1587-1593
    • (2010) Expert Opin Pharmacother , vol.11 , Issue.9 , pp. 1587-1593
    • Cigler, T.1    Vahdat, L.T.2
  • 48
    • 4143052665 scopus 로고    scopus 로고
    • Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halchondrin B macrocyclic ketone analog E7389
    • Kuznetsov G, Towle MJ, Cheng H, Kawamura T, TenDyke K, Liu D et al (2004) Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halchondrin B macrocyclic ketone analog E7389. Cancer Res 64(16):5760-5766
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5760-5766
    • Kuznetsov, G.1    Towle, M.J.2    Cheng, H.3    Kawamura, T.4    Tendyke, K.5    Liu, D.6
  • 49
    • 67649908927 scopus 로고    scopus 로고
    • Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Vahdat LT, Pruitt B, Fabian CJ, Rivera RR, Smith DA, Tan-Chiu E et al (2009) Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 27(18):2954-2961
    • (2009) J Clin Oncol , vol.27 , Issue.18 , pp. 2954-2961
    • Vahdat, L.T.1    Pruitt, B.2    Fabian, C.J.3    Rivera, R.R.4    Smith, D.A.5    Tan-Chiu, E.6
  • 50
    • 77957594393 scopus 로고    scopus 로고
    • Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine
    • Cortes J, Vahdat L, Blum JL, Twelves C, Campone M, Roche H et al (2010) Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine. J Clin Oncol 28(25):3922-3928
    • (2010) J Clin Oncol , vol.28 , Issue.25 , pp. 3922-3928
    • Cortes, J.1    Vahdat, L.2    Blum, J.L.3    Twelves, C.4    Campone, M.5    Roche, H.6
  • 51
    • 79952487463 scopus 로고    scopus 로고
    • Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): A phase 3 open-label randomised study
    • Cortes J, O'Shaughnessy J, Loesch D, Blum JL, Vahdat L, Pe-trakova K et al (2011) Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study. Lancet 377(9769):914-923
    • (2011) Lancet , vol.377 , Issue.9769 , pp. 914-923
    • Cortes, J.1    O'Shaughnessy, J.2    Loesch, D.3    Blum, J.L.4    Vahdat, L.5    Pe-Trakova, K.6
  • 52
    • 77950475001 scopus 로고    scopus 로고
    • Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or meta-static breast cancer
    • Twelves C, Cortes J, Vahdat LT, Wanders J, Akerele C, Kaufman PA (2010) Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or meta-static breast cancer. Clin Breast Cancer 10(2):160-163
    • (2010) Clin Breast Cancer , vol.10 , Issue.2 , pp. 160-163
    • Twelves, C.1    Cortes, J.2    Vahdat, L.T.3    Wanders, J.4    Akerele, C.5    Kaufman, P.A.6
  • 53
    • 52749097817 scopus 로고    scopus 로고
    • Progress on kinesin spindle inhibitors as anti-cancer agents
    • Zhang Y, Xu W (2008) Progress on kinesin spindle inhibitors as anti-cancer agents. Anticancer Agents Med Chem 8(6):698-704
    • (2008) Anticancer Agents Med Chem , vol.8 , Issue.6 , pp. 698-704
    • Zhang, Y.1    Xu, W.2
  • 54
    • 74549223522 scopus 로고    scopus 로고
    • Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer
    • Purcell JW, Davis J, Reddy M, Martin S, Samayoa K, Vo H et al (2010) Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res 16(2):566-576
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 566-576
    • Purcell, J.W.1    Davis, J.2    Reddy, M.3    Martin, S.4    Samayoa, K.5    Vo, H.6
  • 55
    • 42549153290 scopus 로고    scopus 로고
    • Phase II, open label study of SB-715992 (Ispinesib) in subjects with advanced or metastatic breast cancer
    • abstract 1089
    • Miller, K, Ng C, Ang P, Brufsky AM, Lee SC, Dees EC et al. (2005) Phase II, open label study of SB-715992 (Ispinesib) in subjects with advanced or metastatic breast cancer. Breast Cancer Res Treat 94(suppl):abstract 1089
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL.
    • Miller, K.1    Ng, C.2    Ang, P.3    Brufsky, A.M.4    Lee, S.C.5    Dees, E.C.6
  • 56
    • 79955627902 scopus 로고    scopus 로고
    • A phase i study of ispinesib, a kinesin spindle inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors
    • Burris HA III, Jones SF, Williams DD, Kathman SJ, Hodge JP, Pandite L et al (2011) A phase I study of ispinesib, a kinesin spindle inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors. Invest New Drugs 29(3):467-472
    • (2011) Invest New Drugs , vol.29 , Issue.3 , pp. 467-472
    • Burris, H.A.I.I.I.1    Jones, S.F.2    Williams, D.D.3    Kathman, S.J.4    Hodge, J.P.5    Pandite, L.6
  • 57
    • 40349096404 scopus 로고    scopus 로고
    • A phase i trial of ispinesib, a kinesin spindle inhibitor, with docetaxel in patients with advanced tumors
    • Blagden SP, Molife LR, Seebaran A, Payne M, Reid AH, Pro-theroe AS et al (2008) A phase I trial of ispinesib, a kinesin spindle inhibitor, with docetaxel in patients with advanced tumors. Br J Cancer 98(5):894-899
    • (2008) Br J Cancer , vol.98 , Issue.5 , pp. 894-899
    • Blagden, S.P.1    Molife, L.R.2    Seebaran, A.3    Payne, M.4    Reid, A.H.5    Pro-Theroe, A.S.6
  • 58
    • 33845318699 scopus 로고    scopus 로고
    • Phase i study of ispinesib in combination with carboplatin in patients with advanced solid tumors
    • abstract 2027
    • Jones SF, Plummer ER, Burris HA, Razak AR, Meluch AA, Bowen CJ et al. (2006) Phase I study of ispinesib in combination with carboplatin in patients with advanced solid tumors. J Clin Oncol 24(suppl):abstract 2027
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Jones, S.F.1    Plummer, E.R.2    Burris, H.A.3    Razak, A.R.4    Meluch, A.A.5    Bowen, C.J.6
  • 59
    • 34249014574 scopus 로고    scopus 로고
    • Phase i study of ispinesib (SB-715992), a kinesin spindle protein inhibitor, in combination with capecitabine in patients with advanced solid tumors
    • abstract 640
    • Rodon J, Till E, Patnaik A, Takimoto C, Beeram M, Williams D et al. (2006) Phase I study of ispinesib (SB-715992), a kinesin spindle protein inhibitor, in combination with capecitabine in patients with advanced solid tumors. Eur J Cancer Supp 4(12):abstract 640
    • (2006) Eur J Cancer Supp , vol.4 , Issue.12
    • Rodon, J.1    Till, E.2    Patnaik, A.3    Takimoto, C.4    Beeram, M.5    Williams, D.6
  • 61
    • 33750457974 scopus 로고    scopus 로고
    • Vinflunine: A new active drug for second-line treatment of advanced breast cancer, Results of a phase II and pharmacokinetic study inpatients progressing after first-line anthracycline/taxane-based chemotherapy
    • Campone M, Cortes-Funes H, Vorobiof D, Martin M, Slabber CF, Ciruelos E et al (2006) Vinflunine: a new active drug for second-line treatment of advanced breast cancer, Results of a phase II and pharmacokinetic study inpatients progressing after first-line anthracycline/taxane-based chemotherapy. Br J Cancer 95(9):1161-1166
    • (2006) Br J Cancer , vol.95 , Issue.9 , pp. 1161-1166
    • Campone, M.1    Cortes-Funes, H.2    Vorobiof, D.3    Martin, M.4    Slabber, C.F.5    Ciruelos, E.6
  • 62
    • 69349085207 scopus 로고    scopus 로고
    • Phase 2 study of single-agent IV vinflunine as third-line treatment of metastatic breast cancer after failure of anthracycline-/taxane-based chemotherapy
    • Fumoleau P, Cortes-Funes H, Taleb AB, Chan S, Campone M, Pouget JC et al (2009) Phase 2 study of single-agent IV vinflunine as third-line treatment of metastatic breast cancer after failure of anthracycline-/taxane-based chemotherapy. Am J Clin Oncol 32(4):375-380
    • (2009) Am J Clin Oncol , vol.32 , Issue.4 , pp. 375-380
    • Fumoleau, P.1    Cortes-Funes, H.2    Taleb, A.B.3    Chan, S.4    Campone, M.5    Pouget, J.C.6
  • 63
    • 77957978510 scopus 로고    scopus 로고
    • A phase II trial of vinflunine as mono-therapy or in combination with trastuzumab as first-line treatment of metastatic breast cancer
    • Yardley DA, McCleod M, Schreiber F, Yardley DA, McCleod M, Schreiber F et al (2010) A phase II trial of vinflunine as mono-therapy or in combination with trastuzumab as first-line treatment of metastatic breast cancer. Cancer Invest 28(9):925-931
    • (2010) Cancer Invest , vol.28 , Issue.9 , pp. 925-931
    • Yardley, D.A.1    McCleod, M.2    Schreiber, F.3    Yardley, D.A.4    McCleod, M.5    Schreiber, F.6
  • 64
    • 0038419962 scopus 로고    scopus 로고
    • DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo
    • Shionoya M, Jimbo T, Kitagawa M, Soga T, Tohgo A (2003) DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo. Cancer Sci 94(5):459-466
    • (2003) Cancer Sci , vol.94 , Issue.5 , pp. 459-466
    • Shionoya, M.1    Jimbo, T.2    Kitagawa, M.3    Soga, T.4    Tohgo, A.5
  • 65
    • 58249112739 scopus 로고    scopus 로고
    • Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulin
    • Wiencke A, Bacher G (2009) Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulin. Cancer Res 69(1):171-177
    • (2009) Cancer Res , vol.69 , Issue.1 , pp. 171-177
    • Wiencke, A.1    Bacher, G.2
  • 66
    • 0035133804 scopus 로고    scopus 로고
    • D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity
    • Bacher G, Nickel B, Emig P, Vanhoefer U, Seeber S, Shandra A et al (2001) D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. Cancer Res 61(1):392-399
    • (2001) Cancer Res , vol.61 , Issue.1 , pp. 392-399
    • Bacher, G.1    Nickel, B.2    Emig, P.3    Vanhoefer, U.4    Seeber, S.5    Shandra, A.6


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