Possible relation between gut microflora composition and oncogenic risk: Is stimulation of inflammation the one ring of connection?

Reviews and Research in Medical Microbiology

Volumn 23, Issue 3, 2012, Pages 52-57

  Tomasello, Giovanni ^a   Bellavia, Maurizio ^a   Damiano, Giuseppe ^a   Gioviale, Maria C ^a   Lo Monte, Attilio I ^a,b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

chronic in?ammatory intestinal diseases; colorectal cancer; commensal bacteria metabolism; gut micro?ora; intestinal stem cells

Indexed keywords

BETA CATENIN; CYCLOOXYGENASE 2; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72; HISTONE H3; HISTONE H4; INTERLEUKIN 10; SERUM AMYLOID A;

ARTICLE; BACTERIAL METABOLISM; BACTEROIDES; CANCER RISK; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON CARCINOGENESIS; COLORECTAL CANCER; CROHN DISEASE; CYTOPHAGA; ENTERITIS; FLAVOBACTERIUM; HELICOBACTER PYLORI; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INTESTINE FLORA; IRRITABLE COLON; NATURAL KILLER CELL; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY T LYMPHOCYTE; SALMONELLOSIS; TH17 CELL; ULCERATIVE COLITIS; WNT SIGNALING PATHWAY;

EID: 84863719584     PISSN: 0954139X     EISSN: 14735601     Source Type: Journal    
DOI: 10.1097/MRM.0b013e328353f49c     Document Type: Article

References (68)

1. Tomasello G, Bellavia M, Palumbo VD, Gioviale MC, Damiani P, Lo Monte AI. From gut microflora imbalance to mycobacteria infection: is there a relationship with chronic intestinal inflammatory diseases? Ann Ital Chir 2011; 82:361-368.
2. Korn T, Oukka M, Kuchroo V, Bettelli E. Th17 cells: effector T cells with inflammatory properties. Semin Immunol 2007; 19:362-371.
3. Liu Z, Yadav PK, J Su J, Wang J, Fei K. Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2009; 15:5784-5788.
4. Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009; 139:485-498.
5. Bellavia M, Damiano G, Gioviale MC, Palumbo VD, Cacciabaudo F, Buscemi G, et al. Abnormal expansion of segmented filamentous bacteria in the gut: a role in pathogenesis of chronic inflammatory intestinal diseases? Rev Med Microbiol 2011; 22:45-47.
6. Lowe DB, Storkus WJ. Chronic inflammation and immunologicbased constraints in malignant disease. Immunotherapy 2011; 3:1265-1274.
7. Stolfi C, Rizzo A, Franzè E, Rotondi A, Fantini MC, Sarra M, et al. Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J Exp Med 2011; 208:2279-2290.
8. Sethi G, Shanmugam MK, Ramachandran L, Kumar AP, Tergaonkar V. Multifaceted link between cancer and inflammation. Biosci Rep 2012; 32:1-15.
9. Elson CO, Cong Y, McCracken VJ, Dimmitt RA, Lorenz RG, Weaver CT. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev 2005; 206:260-276.
10. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005; 122:107-118.
11. Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut 2009; 58:1629-1636.
12. Brand S. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 2009; 58:1152-1167.
13. Ivanov II, de Llanos Frutos R, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, et al. Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine. Cell Host Microbe 2008; 4:337-349.
14. O'Mahony C, Scully P, O'Mahony D, Murphy S, O'Brien F, Lyons A, et al. Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kB activation. PLoS Pathog 2008; 4:e1000112.
15. Takayama N, Vosshenrich CAJ, Lesjean-Pottier S, Sawa S, Lochner M, Rattis F, et al. Microbial flora drives interleukin 22 production in intestinal NKp46Rcells that provide innate mucosal immune defense. Immunity 2008; 29:958-970.
16. Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, et al. Imbalance of NKp44RNKp46-and NKp44-NKp46Rnatural killer cells in the intestinal mucosa of patients with Crohn's disease. Gastroenterology 2010; 139:882-892.
17. Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 2006; 313:1126-1130.
18. Ogawa H, Fukushima K, Naito H, Funayama Y, Unno M, Takahashi K, et al. Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model. Inflamm Bowel Dis 2003; 9:162-170.
19. van Eden W, Thole JER, van der Zee R, Noordzij A, van Embden JDA, Hensen EJ, et al. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 1988; 331:171-173.
20. Cobelens PM, Heijnen CJ, Nieuwenhuis EE, Kramer PP, van der Zee R, van Eden W, et al. Treatment of adjuvant-induced arthritis by oral administration of mycobacterial HSP 65 during disease. Arthritis Rheum 2000; 43:2694-2702.
21. Birk OS, Douek DC, Elias D, Takacs K, Dewchand H, Gur SL, et al. A role of HSP 60 in autoimmune diabetes: analysis in a transgenic model. Proc Natl Acad Sci U S A 1996; 93:1032-1037.
22. Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR. b-Cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (Dia-Pep277): a randomized, double-blind, phase II trial. Lancet 2001; 358:1749-1753.
23. Maron R, Sukhova G, Faria A-M, Hoffmann E, Mach F, Libby P, et al. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 2002; 106:1708-1715.
24. Rha YH, Taube C, Haczku A, Joetham A, Takeda K, Duez C, et al. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. J Immunol 2002; 169:5300-5307.
25. van Puijvelde GHM, van Es T, van Wanrooij EJA, Habets KLL, de Vos P, van der Zee R, et al. Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis. Arterioscler Thromb Vasc Biol 2007; 27:2677-2683.
26. Ohue R, Hashimoto K, Nakamoto M, Furukawa Y, Masuda T, Kitabatake N, et al. Bacterial heat shock protein 60, GroEL, can induce the conversion of na?̈ve T cells into a CD4RCD25R Foxp3-expressing phenotype. J Innate Immun 2011; 3:605-613.
27. Arvans DL, Vavricka SR, Ren H, Musch MW, Kang L, Rocha FG, et al. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Am J Physiol Gastrointest Liver Physiol 2005; 288:G696-G704.
28. Otani S, Otaka M, Jin M, Okuyama A, Itoh S, Iwabuchi A, et al. Effects of preinduction of heat shock proteins on acetic acidinduced colitis in rats. Dig Dis Sci 1997; 42:833-846.
29. Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Tao Y, De Simone C, et al. Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology 2004; 127:1474-1487.
30. Preville X, Gaestel M, Arrigo AP. Phosphorylation is not essential for protection of L929 cells by HSP25 against H2O2-mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by HSP25. Cell Stress Chaperones 1998; 3:177-187.
31. Sasahara H, Otaka M, Itoh S, Iwabuchi A, Odashima M, Wada I, et al. Effect of preinduction of heat-shock proteins on acetic acid-induced small intestinal lesions in rats. Dig Dis Sci 1998; 43:2117-2130.
32. Fernandez-Cruz E, Alecsandru D, Rodriguez-Sainz C. Introduction to biological drugs. Actas Dermosifilogr 2008; 99:2-6.
33. Paiotti APR, Artigiani Neto R, Forones NM, Oshima CT, Miszputen SJ, Franco M. Immunoexpression of cyclooxygenase-1 and 2 in ulcerative colitis. Brazilian J Med Biol Res 2007; 4:91-98.
34. Cianchi F, Cuzzocrea S, Vinci MC, Messerini L, Comin CE, Navarra G, et al. Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: correlation with tumor angiogenesis. Digest Liver Dis 2010; 42:20-27.
35. Polverini PJ, Strieter RM. Role of proangiogenic cytokines and inhibitors of neovascularization in tumor angiogenesis. In: Voest EE, D'Amore PA, editors. Tumor angiogenesis and microcirculation: New York: Marcel Dekker; 2001. pp. 265-284.
36. Yan B, Wang H, Rabbani ZN, Zhao Y, Li W, Yuan Y, et al. Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. Cancer Res 2006; 66:1565-1570.
37. Davis CD, Milner JA. Gastrointestinal microflora, food components and colon cancer prevention. J Nutr Biochem 2009; 20:743-752.
38. O'Keefe SJ, Ou J, Aufreiter S, O'Connor D, Sharma S, Sepulveda J, et al. Products of the colonic microbiota mediate the effects of diet on colon cancer risk. J Nutr 2009; 139:2044-2048.
39. Wachtershauser A, Stein J. Rationale for the luminal provision of butyrate in intestinal diseases. Eur J Nutr 2000; 39:164-171.
40. Klampfer L, Huang J, Sasazuki T, Shirasawa S, Augenlicht L. Inhibition of interferon gamma signaling by the short chain fatty acid butyrate. Mol Cancer Res 2003; 1:855-862.
41. Zoran DL, Barhoumi R, Burghardt RC, Chapkin RS, Lupton JR. Diet and carcinogen alter luminal butyrate concentrations and intracellular pH in isolated rat colonocytes. Nutr Cancer 1997; 27:222-230.
42. Basson MD, Liu YW, Hanly AM, Emenaker NJ, Shoney SG, Gould Rothberg BE. Identification and comparative analysis of human colonocyte short-chain fatty acid response genes. J Gastrintest Surg 2000; 4:501-512.
43. Pryde SE, Duncan SH, Hold GL, Stewart CS, Flint HJ. The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett 2002; 17:133-139.
44. Ebert MN, Klinder A, Peters WH, Schaferhenrich A, Sendt W, Scheele J, et al. Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTMs by butyrate. Carcinogenesis 2003; 10:1637-1644.
45. Myzak MC, Dashwood RH. Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl sulfide and sulforaphane. Curr Drug Targets 2006; 7:443-452.
46. Goldin BR, Gorbach SL. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazinedihydrochloride-induced intestinal cancer in rats. J Natl Cancer Inst 1980; 64:263-265.
47. Goldin BR, Gualtieri LJ, Moore RP. The effect of Lactobacillus GGon the initiation and promotion of DMH-induced intestinal tumors in the rat. Nutr Cancer 1996; 25:197-204.
48. Pool-Zobel BL, Neudecker C, Domizlaff I, Ji S, Schillinger U, Rumney C, et al. Lactobacillus-and Bifidobacterium-mediated antigenotoxicity in the colon of rats. Nutr Cancer 1996; 26:365-380.
49. Challa A, Rao DR, Chawan CB, Shackelford L. Bifidobacterium longum and lactulose suppress azoxymethane-induced colonic aberrant crypt foci in rats. Carcinogenesis 1997; 18:517-521.
50. Rowland IR, Rumney CJ, Coutts JT, Lievense LC. Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 1998; 19:281-285.
51. Kampman E, Goldbohm RA, Van Den Brandt PA, Van'TVeer P. Fermented dairy products, calcium, and colorectal cancer in The Netherlands Cohort Study. Cancer Res 1994; 54:3186-3190.
52. Kampman E, Van'T. Veer P, Hiddink GJ, Van Aken-Schneijder P, Kok FJ, Hermus RJ. Fermented dairy products, dietary calcium and colon cancer: a case-control study in The Netherlands. Int J Cancer 1994; 59:170-176.
53. Kearney J, Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, et al. Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol 1996; 143:907-917.
54. Malhotra SL. Dietary factors in a study of cancer colon from cancer registry, with special reference to the role of saliva, milk and fermented milk products and vegetable fibre. Med Hypotheses 1977; 3:122-126.
55. Peters RK, Pike MC, Garabrant D, Mack TM. Diet and colon cancer in Los Angeles County, California. Cancer Causes Control 1992; 3:457-473.
56. Boutron MC, Faivre J, Marteau P, Couillault C, Senesse P, Quipourt V. Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case-control study. Br J Cancer 1996; 74:145-151.
57. Kosiewicz MM, Zirnheld AL, Alard P. Gut microbiota, immunity, and disease: a complex relationship. Front Microbiol 2011; 2:1-11.
58. WuS, Rhee KJ, Albesiano E, Rabizadeh S,WuX, Yen HR, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type17 T cell responses. Nat Med 2009; 15:1016-1022.
59. Sfanos KS, Bruno TC, Maris CH, Xu L, Thoburn CJ, Demarzo AM, et al. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH 17 and Treg skewing. Clin Cancer Res 2008; 14:3254-3261.
60. Gnerlich JL, Mitchem JB, Weir JS, Sankpal NV, Kashiwagi H, Belt BA, et al. Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer. J Immunol 2010; 185:4063-4071.
61. Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, et al. Phenotype, distribution, generation and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 2009; 114:1141-1149.
62. Zhang B, Rong G, Wei H, Zhang M, Bi J, Ma L, et al. The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun 2008; 374:533-537.
63. Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 2008; 112:362-373.
64. Louis P, Scott KP, Duncan SH, Flint HJ. Understanding the effects of diet on bacterial metabolism in the large intestine. J Appl Microbiol 2007; 102:1197-1208.
65. Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev 2009; 23:2333-2344.
66. Liu X, Lu R, Wu S, Sun J. Salmonella regulation of intestinal stem cells through the wnt/betacatenin pathway. FEBS Lett 2010; 584:911-916.
67. Lee IO, Kim JH, Choi YJ, Pillinger MH, Kim SY, Blaser MJ, et al. Helicobacter pylori caga phosphorylation status determines the gp130-activated shp2/erk and jak/stat signal transduction pathways in gastric epithelial cells. J Biol Chem 2010; 285:16042-16050.
68. Sun J. Enteric bacteria and cancer stem cells. Cancers (Basel) 2010; 3:285-297; doi: 10.3390/cancers3010285.