메뉴 건너뛰기




Volumn 133, Issue 2, 2012, Pages 523-536

Combination therapy inhibits development and progression of mammary tumours in immunocompetent mice

Author keywords

Bisphosphonates; Breast cancer; Doxorubicin; PyMT MMTV FVB; Zoledronic acid

Indexed keywords

DOXORUBICIN; ZOLEDRONIC ACID;

EID: 84863717286     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1782-x     Document Type: Article
Times cited : (25)

References (49)
  • 1
    • 79951842507 scopus 로고    scopus 로고
    • Anticancer evidence for zoledronic acid across the cancer continuum
    • Costa L, Harper P, Coleman RE, Lipton A (2011) Anticancer evidence for zoledronic acid across the cancer continuum. Crit Rev Oncol Hematol 77(Suppl 1):S31-S37
    • (2011) Crit Rev Oncol Hematol , vol.77 , Issue.SUPPL. 1
    • Costa, L.1    Harper, P.2    Coleman, R.E.3    Lipton, A.4
  • 2
    • 0033554651 scopus 로고    scopus 로고
    • Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates
    • Van Beek E, Pieterman E, Cohen L, Lowik C, Papapoulos S (1999) Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates. Biochem Biophys Res Commun 264(1):108-111
    • (1999) Biochem Biophys Res Commun , vol.264 , Issue.1 , pp. 108-111
    • Van Beek, E.1    Pieterman, E.2    Cohen, L.3    Lowik, C.4    Papapoulos, S.5
  • 3
    • 0033930168 scopus 로고    scopus 로고
    • Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298
    • Coxon FP, Helfrich MH, Van't Hof R, Sebti S, Ralston SH, Hamilton A, Rogers MJ (2000) Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298. J Bone Miner Res 15(8):1467-1476
    • (2000) J Bone Miner Res , vol.15 , Issue.8 , pp. 1467-1476
    • Coxon, F.P.1    Helfrich, M.H.2    Van'T Hof, R.3    Sebti, S.4    Ralston, S.H.5    Hamilton, A.6    Rogers, M.J.7
  • 4
    • 0035146537 scopus 로고    scopus 로고
    • Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
    • Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther 296(2):235-242
    • (2001) J Pharmacol Exp Ther , vol.296 , Issue.2 , pp. 235-242
    • Dunford, J.E.1    Thompson, K.2    Coxon, F.P.3    Luckman, S.P.4    Hahn, F.M.5    Poulter, C.D.6    Ebetino, F.H.7    Rogers, M.J.8
  • 6
    • 0035051719 scopus 로고    scopus 로고
    • Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro
    • Benford HL, McGowan NW, Helfrich MH, Nuttall ME, Rogers MJ (2001) Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. Bone 28(5):465-473
    • (2001) Bone , vol.28 , Issue.5 , pp. 465-473
    • Benford, H.L.1    McGowan, N.W.2    Helfrich, M.H.3    Nuttall, M.E.4    Rogers, M.J.5
  • 7
    • 0035866791 scopus 로고    scopus 로고
    • Bisphosph-onate treatment inhibits the growth of prostate cancer cells
    • Lee MV, Fong EM, Singer FR, Guenette RS (2001) Bisphosph-onate treatment inhibits the growth of prostate cancer cells. Cancer Res 61(6):2602-2608
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2602-2608
    • Lee, M.V.1    Fong, E.M.2    Singer, F.R.3    Guenette, R.S.4
  • 8
    • 0030931858 scopus 로고    scopus 로고
    • Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity
    • Shipman CM, Rogers MJ, Apperley JF, Russell RG, Croucher PI (1997) Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity. Br J Haematol 98(3):665-672
    • (1997) Br J Haematol , vol.98 , Issue.3 , pp. 665-672
    • Shipman, C.M.1    Rogers, M.J.2    Apperley, J.F.3    Russell, R.G.4    Croucher, P.I.5
  • 11
    • 0030826872 scopus 로고    scopus 로고
    • Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices
    • Boissier S, Magnetto S, Frappart L, Cuzin B, Ebetino FH, Delmas PD, Clezardin P (1997) Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices. Cancer Res 57(18):3890-3894
    • (1997) Cancer Res , vol.57 , Issue.18 , pp. 3890-3894
    • Boissier, S.1    Magnetto, S.2    Frappart, L.3    Cuzin, B.4    Ebetino, F.H.5    Delmas, P.D.6    Clezardin, P.7
  • 13
    • 77952388048 scopus 로고    scopus 로고
    • Accumulation of VEGFR2 in zoledronic acid-treated endothelial cells
    • Basi DL, Lee SW, Helfman S, Mariash A, Lunos SA (2010) Accumulation of VEGFR2 in zoledronic acid-treated endothelial cells. Mol Med Report 3(3):399-403
    • (2010) Mol Med Report , vol.3 , Issue.3 , pp. 399-403
    • Basi, D.L.1    Lee, S.W.2    Helfman, S.3    Mariash, A.4    Lunos, S.A.5
  • 14
    • 79951817613 scopus 로고    scopus 로고
    • The backbone of progress-pre-clinical studies and innovations with zoledronic acid
    • Green JR, Guenther A (2011) The backbone of progress-pre-clinical studies and innovations with zoledronic acid. Crit Rev Oncol Hematol 77(Suppl 1):S3-S12
    • (2011) Crit Rev Oncol Hematol , vol.77 , Issue.SUPPL. 1
    • Green, J.R.1    Guenther, A.2
  • 15
    • 78650303812 scopus 로고    scopus 로고
    • The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells
    • Brown HK, Ottewell PD, Coleman RE, Holen I (2011) The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells. J Cell Mol Med 15(3):501-513
    • (2011) J Cell Mol Med , vol.15 , Issue.3 , pp. 501-513
    • Brown, H.K.1    Ottewell, P.D.2    Coleman, R.E.3    Holen, I.4
  • 16
    • 3042729728 scopus 로고    scopus 로고
    • Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model
    • Hiraga T, Williams PJ, Ueda A, Tamura D, Yoneda T (2004) Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clin Cancer Res 10(13):4559-4567
    • (2004) Clin Cancer Res , vol.10 , Issue.13 , pp. 4559-4567
    • Hiraga, T.1    Williams, P.J.2    Ueda, A.3    Tamura, D.4    Yoneda, T.5
  • 17
    • 0037236978 scopus 로고    scopus 로고
    • Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer
    • Corey E, Brown LG, Quinn JE, Poot M, Roudier MP, Higano CS, Vessella RL (2003) Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer. Clin Cancer Res 9(1):295-306
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 295-306
    • Corey, E.1    Brown, L.G.2    Quinn, J.E.3    Poot, M.4    Roudier, M.P.5    Higano, C.S.6    Vessella, R.L.7
  • 18
    • 28844466044 scopus 로고    scopus 로고
    • HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition
    • Gao L, Deng H, Zhao H, Hirbe A, Harding J, Ratner L, Weil-baecher K (2005) HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition. Blood 106(13):4294-4302
    • (2005) Blood , vol.106 , Issue.13 , pp. 4294-4302
    • Gao, L.1    Deng, H.2    Zhao, H.3    Hirbe, A.4    Harding, J.5    Ratner, L.6    Weil-Baecher, K.7
  • 19
    • 0242308942 scopus 로고    scopus 로고
    • Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: Evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival
    • Croucher PI, De Hendrik R, Perry MJ, Hijzen A, Shipman CM, Lippitt J, Green J, Van Marck E, Van Camp B, Vanderkerken K (2003) Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival. J Bone Miner Res 18(3):482-492
    • (2003) J Bone Miner Res , vol.18 , Issue.3 , pp. 482-492
    • Croucher, P.I.1    De Hendrik, R.2    Perry, M.J.3    Hijzen, A.4    Shipman, C.M.5    Lippitt, J.6    Green, J.7    Van Marck, E.8    Van Camp, B.9    Vanderkerken, K.10
  • 20
    • 18144394677 scopus 로고    scopus 로고
    • Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer
    • Kim SJ, Uehara H, Yazici S, He J, Langley RR, Mathew P, Fan D, Fidler IJ (2005) Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer. Cancer Res 65(9):3707-3715
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3707-3715
    • Kim, S.J.1    Uehara, H.2    Yazici, S.3    He, J.4    Langley, R.R.5    Mathew, P.6    Fan, D.7    Fidler, I.J.8
  • 22
    • 0042338751 scopus 로고    scopus 로고
    • Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer
    • Hiraga T, Ueda A, Tamura D, Hata K, Ikeda F, Williams PJ, Yoneda T (2003) Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer. Int J Cancer 106(6):973-979
    • (2003) Int J Cancer , vol.106 , Issue.6 , pp. 973-979
    • Hiraga, T.1    Ueda, A.2    Tamura, D.3    Hata, K.4    Ikeda, F.5    Williams, P.J.6    Yoneda, T.7
  • 24
    • 26444574115 scopus 로고    scopus 로고
    • Zoledronic acid inhibits primary bone tumor growth in Ewing sarcoma
    • Zhou Z, Guan H, Duan X, Kleinerman ES (2005) Zoledronic acid inhibits primary bone tumor growth in Ewing sarcoma. Cancer 104(8):1713-1720
    • (2005) Cancer , vol.104 , Issue.8 , pp. 1713-1720
    • Zhou, Z.1    Guan, H.2    Duan, X.3    Kleinerman, E.S.4
  • 26
    • 77955983146 scopus 로고    scopus 로고
    • Adjuvant bisphosphonates in breast cancer: The ABCSG-12 study
    • Suva LJ (2010) Adjuvant bisphosphonates in breast cancer: the ABCSG-12 study. Curr Osteoporos Rep 8(2):57-59
    • (2010) Curr Osteoporos Rep , vol.8 , Issue.2 , pp. 57-59
    • Suva, L.J.1
  • 27
    • 79960612398 scopus 로고    scopus 로고
    • Is caring for bone also fighting the breast cancer?
    • Coleman RE (2011) Is caring for bone also fighting the breast cancer? Breast 20(Suppl 1):S2
    • (2011) Breast , vol.20 , Issue.SUPPL. 1
    • Coleman, R.E.1
  • 28
    • 51649118688 scopus 로고    scopus 로고
    • Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo
    • Ottewell PD, Deux B, Mönkkönen H, Cross S, Coleman RE, Clezardin P, Holen I (2008) Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo. Clin Cancer Res 14(14):4658-4666
    • (2008) Clin Cancer Res , vol.14 , Issue.14 , pp. 4658-4666
    • Ottewell, P.D.1    Deux, B.2    Mönkkönen, H.3    Cross, S.4    Coleman, R.E.5    Clezardin, P.6    Holen, I.7
  • 29
    • 51049114468 scopus 로고    scopus 로고
    • Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer
    • Ottewell PD, Mönkkönen H, Jones M, Lefley DV, Coleman RE, Holen I (2008) Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. J Natl Cancer Inst 100(16):1167-1178
    • (2008) J Natl Cancer Inst , vol.100 , Issue.16 , pp. 1167-1178
    • Ottewell, P.D.1    Mönkkönen, H.2    Jones, M.3    Lefley, D.V.4    Coleman, R.E.5    Holen, I.6
  • 30
    • 73549086519 scopus 로고    scopus 로고
    • Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxoru-bicin and zoledronic acid in a breast cancer model
    • Ottewell PD, Lefley DV, Cross SS, Evans CA, Coleman RE, Holen I (2010) Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxoru-bicin and zoledronic acid in a breast cancer model. Int J Cancer 126(2):522-532
    • (2010) Int J Cancer , vol.126 , Issue.2 , pp. 522-532
    • Ottewell, P.D.1    Lefley, D.V.2    Cross, S.S.3    Evans, C.A.4    Coleman, R.E.5    Holen, I.6
  • 31
    • 0142244181 scopus 로고    scopus 로고
    • Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    • Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, Pollard JW (2003) Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 163(5):2113-2126
    • (2003) Am J Pathol , vol.163 , Issue.5 , pp. 2113-2126
    • Lin, E.Y.1    Jones, J.G.2    Li, P.3    Zhu, L.4    Whitney, K.D.5    Muller, W.J.6    Pollard, J.W.7
  • 32
    • 4344688268 scopus 로고    scopus 로고
    • Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: Correlation to human disease
    • Qiu TH, Chandramouli GV, Hunter KW, Alkharouf NW, Green JE, Liu ET (2004) Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease. Cancer Res 64(17):5973-5981
    • (2004) Cancer Res , vol.64 , Issue.17 , pp. 5973-5981
    • Qiu, T.H.1    Chandramouli, G.V.2    Hunter, K.W.3    Alkharouf, N.W.4    Green, J.E.5    Liu, E.T.6
  • 33
    • 58549097737 scopus 로고    scopus 로고
    • Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation
    • Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW, Xu J (2009) Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci USA 106(1):151-156
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.1 , pp. 151-156
    • Wang, S.1    Yuan, Y.2    Liao, L.3    Kuang, S.Q.4    Tien, J.C.5    O'Malley, B.W.6    Xu, J.7
  • 34
    • 0030873520 scopus 로고    scopus 로고
    • Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice
    • Ritland SR, Rowse GJ, Chang Y, Gendler SJ (1997) Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice. Cancer Res 57(16):3520-3525
    • (1997) Cancer Res , vol.57 , Issue.16 , pp. 3520-3525
    • Ritland, S.R.1    Rowse, G.J.2    Chang, Y.3    Gendler, S.J.4
  • 35
    • 0141731335 scopus 로고    scopus 로고
    • Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent
    • Kyle AH, Huxham LA, Baker JH, Burston HE, Minchinton AI (2003) Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent. Cancer Res 63(18):5707-5711
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 5707-5711
    • Kyle, A.H.1    Huxham, L.A.2    Baker, J.H.3    Burston, H.E.4    Minchinton, A.I.5
  • 36
    • 0034782530 scopus 로고    scopus 로고
    • Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine
    • Marshman E, Ottewell PD, Potten CS, Watson AJ (2001) Caspase activation during spontaneous and radiation-induced apoptosis in the murine intestine. J Pathol 195(3):285-292
    • (2001) J Pathol , vol.195 , Issue.3 , pp. 285-292
    • Marshman, E.1    Ottewell, P.D.2    Potten, C.S.3    Watson, A.J.4
  • 38
    • 4944239035 scopus 로고    scopus 로고
    • An amino-bisphospho-nate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
    • Giraudo E, Inoue M, Hanahan D (2004) An amino-bisphospho-nate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 114(5):623-633
    • (2004) J Clin Invest , vol.114 , Issue.5 , pp. 623-633
    • Giraudo, E.1    Inoue, M.2    Hanahan, D.3
  • 39
    • 34249981734 scopus 로고    scopus 로고
    • Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor i activity in human ovarian cancer cells
    • Duyndam MC, van Berkel MP, Dorsman JC, Rockx DA, Pinedo HM, Boven E (2007) Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells. Biochem Pharmacol 74(2):191-201
    • (2007) Biochem Pharmacol , vol.74 , Issue.2 , pp. 191-201
    • Duyndam, M.C.1    Van Berkel, M.P.2    Dorsman, J.C.3    Rockx, D.A.4    Pinedo, H.M.5    Boven, E.6
  • 40
    • 70350234896 scopus 로고    scopus 로고
    • Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone
    • Ottewell PD, Woodward JK, Lefley DV, Evans CA, Coleman RE, Holen I (2009) Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone. Mol Cancer Ther 8(10):2821-2832
    • (2009) Mol Cancer Ther , vol.8 , Issue.10 , pp. 2821-2832
    • Ottewell, P.D.1    Woodward, J.K.2    Lefley, D.V.3    Evans, C.A.4    Coleman, R.E.5    Holen, I.6
  • 42
    • 11144254409 scopus 로고    scopus 로고
    • Sequence-and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubi-cin in breast and prostate cancer cells
    • Neville-Webbe HL, Rostami-Hodjegan A, Evans CA, Coleman RE, Holen I (2005) Sequence-and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubi-cin in breast and prostate cancer cells. Int J Cancer 113(3): 364-371
    • (2005) Int J Cancer , vol.113 , Issue.3 , pp. 364-371
    • Neville-Webbe, H.L.1    Rostami-Hodjegan, A.2    Evans, C.A.3    Coleman, R.E.4    Holen, I.5
  • 44
    • 0028129285 scopus 로고
    • Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reduced c-myc expression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin
    • Fornari FA Jr, Jarvis WD, Grant S, Orr MS, Randolph JK, White FK, Mumaw VR, Lovings ET, Freeman RH, Gewirtz DA (1994) Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reduced c-myc expression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin. Cell Growth Differ 5(7):723-733
    • (1994) Cell Growth Differ , vol.5 , Issue.7 , pp. 723-733
    • Fornari, Jr.F.A.1    Jarvis, W.D.2    Grant, S.3    Orr, M.S.4    Randolph, J.K.5    White, F.K.6    Mumaw, V.R.7    Lovings, E.T.8    Freeman, R.H.9    Gewirtz, D.A.10
  • 45
    • 84863719558 scopus 로고    scopus 로고
    • Exploring the anti-angiogenic potential of zoledronic acid in combination with neoadjuvant chemotherapy in invasive breast cancer
    • Winter MC, Evans A, Holen I, Coleman RE (2010) Exploring the anti-angiogenic potential of zoledronic acid in combination with neoadjuvant chemotherapy in invasive breast cancer. Bone 47(Suppl 2):S310-S310
    • (2010) Bone , vol.47 , Issue.SUPPL. 2
    • Winter, M.C.1    Evans, A.2    Holen, I.3    Coleman, R.E.4
  • 46
    • 77955082181 scopus 로고    scopus 로고
    • GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer
    • Lynn KD, Udugamasooriya DG, Roland CL, Castrillon DH, Kodadek TJ, Brekken RA (2010) GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer. BMC Cancer 10:397
    • (2010) BMC Cancer , vol.10 , pp. 397
    • Lynn, K.D.1    Udugamasooriya, D.G.2    Roland, C.L.3    Castrillon, D.H.4    Kodadek, T.J.5    Brekken, R.A.6
  • 48
    • 24044553904 scopus 로고    scopus 로고
    • Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro
    • Woodward JK, Neville-Webbe HL, Coleman RE, Holen I (2005) Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro. Anticancer Drugs 16(8):845-854
    • (2005) Anticancer Drugs , vol.16 , Issue.8 , pp. 845-854
    • Woodward, J.K.1    Neville-Webbe, H.L.2    Coleman, R.E.3    Holen, I.4
  • 49
    • 33645814413 scopus 로고    scopus 로고
    • Cyto-solic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis
    • Thompson K, Rogers MJ, Coxon FP, Crockett JC (2006) Cyto-solic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis. Mol Pharmacol 69(5): 1624-1632
    • (2006) Mol Pharmacol , vol.69 , Issue.5 , pp. 1624-1632
    • Thompson, K.1    Rogers, M.J.2    Coxon, F.P.3    Crockett, J.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.