-
1
-
-
0033544499
-
Hepatitis C: Global prevalence (update)
-
WHO
-
WHO. Hepatitis C: global prevalence (update). Wkly Epidemiol Rec 1999;49(74):425-7
-
(1999)
Wkly Epidemiol Rec
, vol.49
, Issue.74
, pp. 425-427
-
-
-
2
-
-
0033428642
-
Natural history and pathogenesis of hepatitis C virus related hepatocellular carcinoma
-
Colombo M. Natural history and pathogenesis of hepatitis C virus related hepatocellular carcinoma. J Hepatol 1999;31(Suppl 1):25-30 (Pubitemid 30002687)
-
(1999)
Journal of Hepatology, Supplement
, vol.31
, Issue.1
, pp. 25-30
-
-
Colombo, M.1
-
3
-
-
22044433989
-
Natural history of hepatitis C
-
DOI 10.1016/j.cld.2005.05.003, PII S1089326105000358, Hepatitis C Virus
-
Thomas DL, Seeff LB. Natural history of hepatitis C. Clin Liver Dis 2005;9(3):383-98, vi (Pubitemid 40968202)
-
(2005)
Clinics in Liver Disease
, vol.9
, Issue.3
, pp. 383-398
-
-
Thomas, D.L.1
Seeff, L.B.2
-
4
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
DOI 10.1016/S0140-6736(01)06102-5
-
Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358(9286):958-65 (Pubitemid 32913521)
-
(2001)
Lancet
, vol.358
, Issue.9286
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
Rustgi, V.K.4
Shiffman, M.5
Reindollar, R.6
Goodman, Z.D.7
Koury, K.8
Ling, M.-H.9
Albrecht, J.K.10
-
5
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347(13):975-82
-
(2002)
N Engl J Med
, vol.347
, Issue.13
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
6
-
-
68249154875
-
Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
-
McHutchison JG, Lawitz EJ, Shiffman ML, et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med 2009;361(6):580-93
-
(2009)
N Engl J Med
, vol.361
, Issue.6
, pp. 580-593
-
-
McHutchison, J.G.1
Lawitz, E.J.2
Shiffman, M.L.3
-
7
-
-
75449106958
-
Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis
-
Bruno S, Shiffman ML, Roberts SK, et al. Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis. Hepatology 2010;51(2):388-97
-
(2010)
Hepatology
, vol.51
, Issue.2
, pp. 388-397
-
-
Bruno, S.1
Shiffman, M.L.2
Roberts, S.K.3
-
8
-
-
70349292099
-
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
-
Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009;461(7262):399-401
-
(2009)
Nature
, vol.461
, Issue.7262
, pp. 399-401
-
-
Ge, D.1
Fellay, J.2
Thompson, A.J.3
-
9
-
-
0345188811
-
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
-
DOI 10.1126/science.285.5424.110
-
Lohmann V, Korner F, Koch J, et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999;285(5424):110-13 (Pubitemid 29307577)
-
(1999)
Science
, vol.285
, Issue.5424
, pp. 110-113
-
-
Lohmann, V.1
Korner, F.2
Koch, J.-O.3
Herian, U.4
Theilmann, L.5
Bartenschlager, R.6
-
10
-
-
0036835773
-
Hepatitis C virus replicons: Potential role for drug development
-
DOI 10.1038/nrd942
-
Bartenschlager R. Hepatitis C virus replicons: potential role for drug development. Nat Rev Drug Discov 2002;1(11):911-16 (Pubitemid 37361585)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.11
, pp. 911-916
-
-
Bartenschlager, R.1
-
11
-
-
23744446809
-
HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase
-
Tomei L, Altamura S, Paonessa G, et al. HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase. Antivir Chem Chemother 2005;16(4):225-45 (Pubitemid 41139709)
-
(2005)
Antiviral Chemistry and Chemotherapy
, vol.16
, Issue.4
, pp. 225-245
-
-
Tomei, L.1
Altamura, S.2
Paonessa, G.3
De Francesco, R.4
Migliaccio, G.5
-
13
-
-
0031735768
-
Molecular virology of hepatitis C virus: An update with respect to potential antiviral targets
-
Blight KJ, Kolykhalov AA, Reed KE, et al. Molecular virology of hepatitis C virus: an update with respect to potential antiviral targets. Antivir Ther 1998;3(Suppl 3):71-81 (Pubitemid 28528323)
-
(1998)
Antiviral Therapy
, vol.3
, Issue.SUPPL. 3
, pp. 71-81
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Reed, K.E.3
Agapov, E.V.4
Rice, C.M.5
-
14
-
-
0027176287
-
NS3 is a serine protease required for processing of hepatitis C virus polyprotein
-
Tomei L, Failla C, Santolini E, et al. NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol 1993;67(7):4017-26 (Pubitemid 23180726)
-
(1993)
Journal of Virology
, vol.67
, Issue.7
, pp. 4017-4026
-
-
Tomei, L.1
Failla, C.2
Santolini, E.3
De Francesco, R.4
La, M.N.5
-
15
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
Poordad F, McCone J Jr, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011;364(13):1195-206
-
(2011)
N Engl J Med
, vol.364
, Issue.13
, pp. 1195-1206
-
-
Poordad, F.1
McCone Jr., J.2
Bacon, B.R.3
-
16
-
-
80052826527
-
Response-guided telaprevir combination treatment for hepatitis C virus infection
-
Sherman KE, Flamm SL, Afdhal NH, et al. Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011;365(11):1014-24
-
(2011)
N Engl J Med
, vol.365
, Issue.11
, pp. 1014-1024
-
-
Sherman, K.E.1
Flamm, S.L.2
Afdhal, N.H.3
-
17
-
-
79959381354
-
Telaprevir for retreatment of HCV infection
-
Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011;364(25):2417-28
-
(2011)
N Engl J Med
, vol.364
, Issue.25
, pp. 2417-2428
-
-
Zeuzem, S.1
Andreone, P.2
Pol, S.3
-
18
-
-
79952307519
-
The results of Phase III clinical trials with telaprevir and boceprevir presented at the Liver Meeting 2010: A new standard of care for hepatitis C virus genotype 1 infection, but with issues still pending
-
Pawlotsky JM. The results of Phase III clinical trials with telaprevir and boceprevir presented at the Liver Meeting 2010: a new standard of care for hepatitis C virus genotype 1 infection, but with issues still pending. Gastroenterology 2011;140(3):746-54
-
(2011)
Gastroenterology
, vol.140
, Issue.3
, pp. 746-754
-
-
Pawlotsky, J.M.1
-
19
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
Jacobson IM, McHutchison JG, Dusheiko G, et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med 2011;364(25):2405-16
-
(2011)
N Engl J Med
, vol.364
, Issue.25
, pp. 2405-2416
-
-
Jacobson, I.M.1
McHutchison, J.G.2
Dusheiko, G.3
-
20
-
-
50049107010
-
Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350
-
A concise review of the chemistry of TMC435 and other macrocyclic protease
-
Raboisson P, de Kock H, Rosenquist A, et al. Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett 2008;18(17):4853-8 A concise review of the chemistry of TMC435 and other macrocyclic protease.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, Issue.17
, pp. 4853-4858
-
-
Raboisson, P.1
De Kock, H.2
Rosenquist, A.3
-
21
-
-
32644490562
-
A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus
-
DOI 10.1016/j.antiviral.2005.12.001, PII S0166354205002603
-
Thimme R, Lohmann V, Weber F. A target on the move: innate and adaptive immune escape strategies of hepatitis C virus. Antivir Res 2006;69(3):129-41 (Pubitemid 43247333)
-
(2006)
Antiviral Research
, vol.69
, Issue.3
, pp. 129-141
-
-
Thimme, R.1
Lohmann, V.2
Weber, F.3
-
22
-
-
45749088957
-
Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?
-
DOI 10.1093/jac/dkn175
-
Soriano V, Perelson AS, Zoulim F. Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? J Antimicrob Chemother 2008;62(1):1-4 (Pubitemid 351865869)
-
(2008)
Journal of Antimicrobial Chemotherapy
, vol.62
, Issue.1
, pp. 1-4
-
-
Soriano, V.1
Perelson, A.S.2
Zoulim, F.3
-
23
-
-
36549028822
-
Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient
-
DOI 10.1016/j.virol.2007.10.006, PII S0042682207006629
-
Cubero M, Esteban JI, Otero T, et al. Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient. Virology 2008;370(2):237-45 (Pubitemid 350192568)
-
(2008)
Virology
, vol.370
, Issue.2
, pp. 237-245
-
-
Cubero, M.1
Esteban, J.I.2
Otero, T.3
Sauleda, S.4
Bes, M.5
Esteban, R.6
Guardia, J.7
Quer, J.8
-
24
-
-
34247594930
-
Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir
-
DOI 10.1053/j.gastro.2007.02.037, PII S0016508507003940
-
Sarrazin C, Kieffer TL, Bartels D, et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007;132(5):1767-77 (Pubitemid 46677938)
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1767-1777
-
-
Sarrazin, C.1
Kieffer, T.L.2
Bartels, D.3
Hanzelka, B.4
Muh, U.5
Welker, M.6
Wincheringer, D.7
Zhou, Y.8
Chu, H.9
Lin, C.10
Weegink, C.11
Reesink, H.12
Zeuzem, S.13
Kwong, A.D.14
-
25
-
-
77649127624
-
Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target
-
Cummings MD, Lindberg J, Lin TI, et al. Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target. Angew Chem Int Ed Engl 2010;49(9):1652-5
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, Issue.9
, pp. 1652-1655
-
-
Cummings, M.D.1
Lindberg, J.2
Lin, T.I.3
-
26
-
-
46449115901
-
The exploration of macrocycles for drug discovery - An underexploited structural class
-
DOI 10.1038/nrd2590, PII NRD2590
-
Driggers EM, Hale SP, Lee J, Terrett NK. The exploration of macrocycles for drug discovery--an underexploited structural class. Nat Rev Drug Discov 2008;7(7):608-24 (Pubitemid 351927725)
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, Issue.7
, pp. 608-624
-
-
Driggers, E.M.1
Hale, S.P.2
Lee, J.3
Terrett, N.K.4
-
27
-
-
7944233573
-
The design of a potent inhibitor of the hepatitis C virus NS3 protease: BILN 2061 - From the NMR tube to the clinic
-
DOI 10.1002/bip.20127
-
Tsantrizos YS. The design of a potent inhibitor of the hepatitis C virus NS3 protease: BILN 2061--from the NMR tube to the clinic. Biopolymers 2004;76(4):309-23 (Pubitemid 39468254)
-
(2004)
Biopolymers - Peptide Science Section
, vol.76
, Issue.4
, pp. 309-323
-
-
Tsantrizos, Y.S.1
-
28
-
-
65749112245
-
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
-
Lin TI, Lenz O, Fanning G, et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor. Antimicrob Agents Chemother 2009;53(4):1377-85
-
(2009)
Antimicrob Agents Chemother
, vol.53
, Issue.4
, pp. 1377-1385
-
-
Lin, T.I.1
Lenz, O.2
Fanning, G.3
-
29
-
-
84872209766
-
Combination of TMC435 with two novel NS5B inhibitors increases anti-HCV activity and results in a higher genetic barrier in vitro
-
Lenz O, Berke JM, de Kock H, et al. Combination of TMC435 with two novel NS5B inhibitors increases anti-HCV activity and results in a higher genetic barrier in vitro. J Hepatol 2010;52(Suppl 1):S295-S96
-
(2010)
J Hepatol
, vol.52
, Issue.SUPPL. 1
-
-
Lenz, O.1
Berke, J.M.2
De Kock, H.3
-
30
-
-
77951210464
-
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435
-
Lenz O, Verbinnen T, Lin TI, et al. In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435. Antimicrob Agents Chemother 2010;54(5):1878-87
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.5
, pp. 1878-1887
-
-
Lenz, O.1
Verbinnen, T.2
Lin, T.I.3
-
31
-
-
84872218656
-
Evaluation of metabolic interactions for TMC435 via cytochrome P450 (CYP) enzymes in healthy volunteers
-
Sekar V, Verloes R, Meyvisch P, et al. Evaluation of metabolic interactions for TMC435 via cytochrome P450 (CYP) enzymes in healthy volunteers. J Hepatol 2010;52(Suppl 1):S416
-
(2010)
J Hepatol
, vol.52
, Issue.SUPPL. 1
-
-
Sekar, V.1
Verloes, R.2
Meyvisch, P.3
-
32
-
-
84872220905
-
Pharmacokinetic-pharmacodynamic (PK-PD) analyses of TMC435 in treatment-naive hepatitis C (HCV)-infected patients in the OPERA-1 study
-
Sekar V, Vis P, Lenz O, et al. Pharmacokinetic-pharmacodynamic (PK-PD) analyses of TMC435 in treatment-naive hepatitis C (HCV)-infected patients in the OPERA-1 study. J Hepatol 2010;52(Suppl 1):S416
-
(2010)
J Hepatol
, vol.52
, Issue.SUPPL. 1
-
-
Sekar, V.1
Vis, P.2
Lenz, O.3
-
33
-
-
84863641361
-
Pharmacokinetics of TMC435 in subjects with moderate hepatic impairment
-
Sekar V, Simion A, Peeters M, et al. Pharmacokinetics of TMC435 in subjects with moderate hepatic impairment. J Hepatol 2011;54(Suppl 1):S193
-
(2011)
J Hepatol
, vol.54
, Issue.SUPPL. 1
-
-
Sekar, V.1
Simion, A.2
Peeters, M.3
-
34
-
-
84872205032
-
The pharmacokinetic interaction between the investigational HCV NS3/4A protease inhibitor TMC435 and escitalopram
-
Beumont-Mauviel M, Simion A, De Smedt G, et al. The pharmacokinetic interaction between the investigational HCV NS3/4A protease inhibitor TMC435 and escitalopram. AASLD 2011 Annual Meeting; 2011
-
(2011)
AASLD 2011 Annual Meeting
-
-
Beumont-Mauviel, M.1
Simion, A.2
De Smedt, G.3
-
35
-
-
84872219739
-
The pharmacokinetic interaction between the investigational NS3-4A HCV protease inhibitor TMC435 and methadone
-
Beumont-Mauviel M, De Smedt G, Peeters M, et al. The pharmacokinetic interaction between the investigational NS3-4A HCV protease inhibitor TMC435 and methadone. AASLD 2011 Annual Meetng; 2011
-
AASLD 2011 Annual Meetng; 2011
-
-
Beumont-Mauviel, M.1
De Smedt, G.2
Peeters, M.3
-
36
-
-
77449158033
-
Rapid HCV-RNA decline with once daily TMC435: A phase I study in healthy volunteers and hepatitis C patients
-
This is a comprehensive summary of the Phase I TMC435 trial
-
Reesink HW, Fanning GC, Farha KA, et al. Rapid HCV-RNA decline with once daily TMC435: a phase I study in healthy volunteers and hepatitis C patients. Gastroenterology 2010;138(3):913-21 This is a comprehensive summary of the Phase I TMC435 trial.
-
(2010)
Gastroenterology
, vol.138
, Issue.3
, pp. 913-921
-
-
Reesink, H.W.1
Fanning, G.C.2
Farha, K.A.3
-
37
-
-
80055076797
-
Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: A randomized trial
-
This is a comprehensive summary of the OPERA-1 TMC435 trial
-
Manns M, Reesink H, Berg T, et al. Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: a randomized trial. Antivir Ther 2011;16(7):1021-33 This is a comprehensive summary of the OPERA-1 TMC435 trial.
-
(2011)
Antivir Ther
, vol.16
, Issue.7
, pp. 1021-1033
-
-
Manns, M.1
Reesink, H.2
Berg, T.3
-
38
-
-
84863670207
-
Treatment outcome and resistance analysis in HCV genotype 1 patients previously exposed to TMC435 monotherapy and re-treated with TMC435 in combination with PEGIFNalpha-2a/ribavirin
-
Lenz O, de Bruijne J, Vijgen L, et al. Treatment outcome and resistance analysis in HCV genotype 1 patients previously exposed to TMC435 monotherapy and re-treated with TMC435 in combination with PEGIFNalpha-2a/ribavirin. J Hepatol 2011;54(Suppl 1):S482-S83
-
(2011)
J Hepatol
, vol.54
, Issue.SUPPL. 1
-
-
Lenz, O.1
De Bruijne, J.2
Vijgen, L.3
-
39
-
-
84861188748
-
Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2 to 6: TMC435-C202, a phase IIa, open-label study
-
Epub ahead of print
-
Moreno C, Berg T, Tanwandee T, et al. Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2 to 6: TMC435-C202, a phase IIa, open-label study. J Hepatol 2012. [Epub ahead of print]
-
(2012)
J Hepatol
-
-
Moreno, C.1
Berg, T.2
Tanwandee, T.3
-
40
-
-
84872220578
-
In vitro studies investigating the mechanism of interaction between TMC435 and hepatic transporters
-
Huisman M, Snoeys J, Monbaliu J, et al. In vitro studies investigating the mechanism of interaction between TMC435 and hepatic transporters. AASLD 2010; 2010
-
(2010)
AASLD 2010
-
-
Huisman, M.1
Snoeys, J.2
Monbaliu, J.3
-
41
-
-
84872208844
-
TMC435 in combination with peginterferon and ribavirin in treatment-naive HCV genotype 1 patients: Final analysis of the PILLAR phase IIB study
-
Epub ahead of print
-
Fried M, Buti M, Dore GJ, et al. TMC435 in combination with peginterferon and ribavirin in treatment-naive HCV genotype 1 patients: final analysis of the PILLAR phase IIB study. [Epub ahead of print] AASLD 2011 Annual Meetng; 2011
-
AASLD 2011 Annual Meetng; 2011
-
-
Fried, M.1
Buti, M.2
Dore, G.J.3
-
42
-
-
79961041471
-
Impact of IL28B genotype and pretreatment serum IP-10 in treatment-naive genotype-1 HCV patients treated with TMC435 in combination with peginterferona-2a and ribavirin in PILLAR study
-
Aerssens J, Fanning G, Scholliers A, et al. Impact of IL28B genotype and pretreatment serum IP-10 in treatment-naive genotype-1 HCV patients treated with TMC435 in combination with peginterferona-2a and ribavirin in PILLAR study. J Hepatol 2011;54(Suppl 1):S5-6
-
(2011)
J Hepatol
, vol.54
, Issue.SUPPL. 1
-
-
Aerssens, J.1
Fanning, G.2
Scholliers, A.3
-
43
-
-
84872220109
-
TMC435 in combination with peginterferon alpha-2a/ribavirin in treatment-naive patients infected with HCV genotype 1: Virology analysis of the PILLAR study
-
Lenz O, Fevery B, Vijgen L, et al. TMC435 in combination with peginterferon alpha-2a/ribavirin in treatment-naive patients infected with HCV genotype 1: virology analysis of the PILLAR study. AASLD 2011 Annual Meetng; 2011
-
AASLD 2011 Annual Meetng; 2011
-
-
Lenz, O.1
Fevery, B.2
Vijgen, L.3
-
44
-
-
72049102993
-
Antiviral activity and safety of TMC435 combined with peginterferon alpha-2a and ribavirin in patients with genotype 1 hepatitis C infection who failed previous IFN-based therapy
-
Marcellin P, Reesink H, Berg T, et al. Antiviral activity and safety of TMC435 combined with peginterferon alpha-2a and ribavirin in patients with genotype 1 hepatitis C infection who failed previous IFN-based therapy. J Hepatol 2009;50(Suppl 1):S385
-
(2009)
J Hepatol
, vol.50
, Issue.SUPPL. 1
-
-
Marcellin, P.1
Reesink, H.2
Berg, T.3
-
45
-
-
79960472450
-
The ASPIRE trial: TMC435 in treatment-experienced patients with genotype-1 HCV infection who have failed previous PEGIFN/RBV treatment
-
Zeuzem S, Foster GR, Fried MW, et al. The ASPIRE trial: TMC435 in treatment-experienced patients with genotype-1 HCV infection who have failed previous PEGIFN/RBV treatment. J Hepatol 2011;54(Suppl 1):S546
-
(2011)
J Hepatol
, vol.54
, Issue.SUPPL. 1
-
-
Zeuzem, S.1
Foster, G.R.2
Fried, M.W.3
-
46
-
-
84872210750
-
Once-Daily PSI-7977 Plus Peg/RBV in Treatment-naive Patients with HCV GT1: Robust End of Treatment Response Rates are Sustained Post-treatment
-
Lawitz E, Lalezari JP, Hassanein T, et al. Once-Daily PSI-7977 Plus Peg/RBV in Treatment-naive Patients with HCV GT1: Robust End of Treatment Response Rates are Sustained Post-treatment. AASLD 2011 Annual Meetng; 2011
-
AASLD 2011 Annual Meetng; 2011
-
-
Lawitz, E.1
Lalezari, J.P.2
Hassanein, T.3
-
47
-
-
79960735084
-
Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials
-
Sullivan JC, De Meyer S, Bartels DJ, et al. Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials. J Hepatol 2011;54(Suppl 1):S4
-
(2011)
J Hepatol
, vol.54
, Issue.SUPPL. 1
-
-
Sullivan, J.C.1
De Meyer, S.2
Bartels, D.J.3
-
48
-
-
84855246805
-
Future treatment of chronic hepatitis C with direct acting antivirals: Is resistance important?
-
Halfon P, Sarrazin C. Future treatment of chronic hepatitis C with direct acting antivirals: is resistance important? Liver Int 2012;32:79-87
-
(2012)
Liver Int
, vol.32
, pp. 79-87
-
-
Halfon, P.1
Sarrazin, C.2
-
49
-
-
67649112292
-
Perspectives on the management of chronic hepatitis B and C
-
Dusheiko GM, Jacobs MG. Perspectives on the management of chronic hepatitis B and C. Expert Rev Anti Infect Ther 2009;7(3):243-7
-
(2009)
Expert Rev Anti Infect Ther
, vol.7
, Issue.3
, pp. 243-247
-
-
Dusheiko, G.M.1
Jacobs, M.G.2
-
50
-
-
80051920720
-
Second-wave protease inhibitors: Choosing an heir
-
Ciesek S, von Hahn T, Manns MP. Second-wave protease inhibitors: choosing an heir. Clin Liver Dis 2011;15(3):597-609
-
(2011)
Clin Liver Dis
, vol.15
, Issue.3
, pp. 597-609
-
-
Ciesek, S.1
Von Hahn, T.2
Manns, M.P.3
-
51
-
-
79953224799
-
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection
-
Manns MP, Bourliere M, Benhamou Y, et al. Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection. J Hepatol 2011;54(6):1114-22
-
(2011)
J Hepatol
, vol.54
, Issue.6
, pp. 1114-1122
-
-
Manns, M.P.1
Bourliere, M.2
Benhamou, Y.3
-
52
-
-
80051916510
-
Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients
-
Gane EJ, Rouzier R, Stedman C, et al. Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients. J Hepatol 2011;55(5):972-9
-
(2011)
J Hepatol
, vol.55
, Issue.5
, pp. 972-979
-
-
Gane, E.J.1
Rouzier, R.2
Stedman, C.3
-
53
-
-
73849106636
-
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease
-
Liverton NJ, Carroll SS, Dimuzio J, et al. MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother 2010;54(1):305-11
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.1
, pp. 305-311
-
-
Liverton, N.J.1
Carroll, S.S.2
Dimuzio, J.3
|