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Volumn 25, Issue 2, 2012, Pages 435-444

A validated HPLC method for the monitoring of thiopurine metabolites in whole blood in paediatric patients with inflammatory bowel disease

Author keywords

Chron's disease; Diagnostic test; Inflammatory bowel disease; Thiopurines

Indexed keywords

6 METHYLTHIOINOSINE; 6 THIOGUANINE NUCLEOTIDE; DRUG METABOLITE; MERCAPTOPURINE; UNCLASSIFIED DRUG; 6 MERCAPTOPURINE DERIVATIVE; 6 METHYLMERCAPTOPURINE; AZATHIOPRINE; THIOGUANINE DERIVATIVE;

EID: 84863699116     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201202500213     Document Type: Article
Times cited : (24)

References (29)
  • 1
    • 0037303503 scopus 로고    scopus 로고
    • Recent advances in the treatment and understanding of childhood acute lymphosblastic leukaemia
    • DOI 10.1016/S0305-7372(02)00106-8
    • Rubnitz JE, Pui CH. Recent advances in the treatment and understanding of childhood acute lymphoblastic leukaemia. Cancer Treat Rev 2003; 29:31-44. (Pubitemid 36395521)
    • (2003) Cancer Treatment Reviews , vol.29 , Issue.1 , pp. 31-44
    • Rubnitz, J.E.1    Pui, C.-H.2
  • 2
    • 14644394897 scopus 로고    scopus 로고
    • Review article: Monitoring of immunomodulators in inflammatory bowel disease
    • DOI 10.1111/j.1365-2036.2005.02343.x
    • Aberra FN, Lichtenstein GR. Review article: monitoring of immunomodulators in inflammatory bowel disease. Aliment Pharmacol Ther 2005; 21:307-19. (Pubitemid 40313935)
    • (2005) Alimentary Pharmacology and Therapeutics , vol.21 , Issue.4 , pp. 307-319
    • Aberra, F.N.1    Lichtenstein, G.R.2
  • 3
    • 0022401174 scopus 로고
    • The pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and azathioprine
    • Van Scoik KG, Johnson CA, Porter WR. The pharmacology and metabolism of the thiopurine drugs 6-mercaptopurine and azathioprine. Drug Metab Rev 1985; 16:157-74. (Pubitemid 16191932)
    • (1985) Drug Metabolism Reviews , vol.16 , Issue.1-2 , pp. 157-174
    • Van Scoik, K.G.1    Johnson, C.A.2    Porter, W.R.3
  • 4
    • 76749153792 scopus 로고    scopus 로고
    • Review. On therapeutic drug monitoring of thiopurines in inflammatory bowel disease; pharmacology, pharmacogenomics, drug intolerance and clinical relevance
    • Van Asseldonk DP, de Boer NK, Peters GJ, Veldkamp AI, Mulder CJ, Van Bodegraven AA. Review. On therapeutic drug monitoring of thiopurines in inflammatory bowel disease; pharmacology, pharmacogenomics, drug intolerance and clinical relevance. Curr Drug Metab 2009; 10:981-97.
    • (2009) Curr Drug Metab , vol.10 , pp. 981-997
    • Van Asseldonk, D.P.1    De Boer, N.K.2    Peters, G.J.3    Veldkamp, A.I.4    Mulder, C.J.5    Van Bodegraven, A.A.6
  • 6
    • 0026465403 scopus 로고
    • High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample
    • Lennard L, Singleton HJ. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample. J Chromatogr 1992; 583:83-90.
    • (1992) J Chromatogr , vol.583 , pp. 83-90
    • Lennard, L.1    Singleton, H.J.2
  • 7
    • 0030021288 scopus 로고    scopus 로고
    • High-performance liquid chromatographic assay for the measurement of azathioprine in human serum samples
    • DOI 10.1016/0378-4347(95)00365-7
    • Bmscheck T, Meyer H, Wellhrner HH. High-performance liquid chromatographic assay for the measurement of azathioprine in human serum samples. J Chromatogr B 1996; 675:287-94. (Pubitemid 26067259)
    • (1996) Journal of Chromatography B: Biomedical Applications , vol.675 , Issue.2 , pp. 287-294
    • Binscheck, T.1    Meyer, H.2    Wellhoner, H.H.3
  • 9
    • 0344563423 scopus 로고    scopus 로고
    • Assay of 6-mercaptopurine and its metabolites in patient plasma by high- performance liquid chromatography with diode-array detection
    • DOI 10.1016/S0378-4347(99)00311-4, PII S0378434799003114
    • Su Y, Hon YY, Chu Y, Van de Poll ME, Relling MV. Assay of 6-mercaptopurine and its metabolites in patient plasma by high-performance liquid chromatography with diode-array detection. J Chromatogr B 1999; 732:459-68. (Pubitemid 29460862)
    • (1999) Journal of Chromatography B: Biomedical Sciences and Applications , vol.732 , Issue.2 , pp. 459-468
    • Su, Y.1    Hon, Y.Y.2    Chu, Y.3    Van De, P.M.E.C.4    Relling, M.V.5
  • 10
    • 79955828365 scopus 로고    scopus 로고
    • Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease
    • Haines ML, Ajlouni Y, Irving PM, Sparrow MP, Rose R, Gearry RB, Gibson PR. Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease. Inflamm Bowel Dis 2011; 17:1301-7.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1301-1307
    • Haines, M.L.1    Ajlouni, Y.2    Irving, P.M.3    Sparrow, M.P.4    Rose, R.5    Gearry, R.B.6    Gibson, P.R.7
  • 13
    • 0031889642 scopus 로고    scopus 로고
    • Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC
    • Dervieux T, Boulieu R. Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC. Clin Chem 1998; 44:551-55. (Pubitemid 28141350)
    • (1998) Clinical Chemistry , vol.44 , Issue.3 , pp. 551-555
    • Dervieux, T.1    Boulieu, R.2
  • 14
    • 0037305373 scopus 로고    scopus 로고
    • Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods
    • DOI 10.1373/49.2.260
    • Shipkova M, Armstrong VW, Wieland E, Oellerich M. Differences in Nucleotide Hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods. Clin Chem 2003; 49:260-68. (Pubitemid 36143448)
    • (2003) Clinical Chemistry , vol.49 , Issue.2 , pp. 260-268
    • Shipkova, M.1    Armstrong, V.W.2    Wieland, E.3    Oellerich, M.4
  • 15
    • 0031648054 scopus 로고    scopus 로고
    • Identification of 6-methylmercaptopurine derivative formed during acid hydrolysis of thiopurine nucleotides in erythrocytes, using liquid chromatography-mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance assay
    • Dervieux T, Boulieu R. Identification of 6-methylmercaptopurine derivative formed during acid hydrolysis of thiopurine nucleotides in erythrocytes, using liquid chromatography-mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance assay. Clin Chem 1998; 44:2511-15. (Pubitemid 28565664)
    • (1998) Clinical Chemistry , vol.44 , Issue.12 , pp. 2511-2515
    • Dervieux, T.1    Boulieu, R.2
  • 17
    • 0003484310 scopus 로고    scopus 로고
    • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologies Evaluation and Research (CBER), Rockville, May
    • Guidance for industry: Bioanalytical Method Validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologies Evaluation and Research (CBER), Rockville, May 2001.
    • (2001) Guidance for Industry: Bioanalytical Method Validation
  • 18
    • 84908219488 scopus 로고
    • Statistical methods for assessing agreement between two methods of clinical measurement
    • PII S0140673686908378
    • Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 327:307-10. (Pubitemid 16134762)
    • (1986) Lancet , vol.1 , Issue.8476 , pp. 307-310
    • Bland, J.M.1    Altman, D.G.2
  • 19
    • 0031423875 scopus 로고    scopus 로고
    • Patterns of azathioprine metabolites in neutrophils, lymphocytes, reticulocytes, and erythrocytes: Relevance to toxicity and monitoring in recipients of renal allografts
    • DOI 10.1097/00007691-199710000-00003
    • Bergan S, Bentdal O, Sødal G, Brun A, Rugstad HE, Stokke O. Patterns of azathioprine metabolites in neutrophils, lymphocytes, reticulocytes, and erythrocytes: relevance to toxicity and monitoring in recipients of renal allografts. Ther Drug Monit 1997; 19:502-9. (Pubitemid 28116825)
    • (1997) Therapeutic Drug Monitoring , vol.19 , Issue.5 , pp. 502-509
    • Bergan, S.1    Bentdal, O.2    Sodal, G.3    Brun, A.4    Rugstad, H.E.5    Stokke, O.6
  • 20
    • 0029987936 scopus 로고    scopus 로고
    • Detection and identification of 6-methylmercapto-8-hydroxypurine, a major metabolite of 6-mercaptopurine, in plasma during intravenous administration
    • Keuzenkamp-Jansen CW, van Baal JM, De Abreu RA, de Jong JG, Zuiderent R, Trijbels JM. Detection and identification of 6-methylmercapto-8-hydroxypurine, a major metabolite of 6-mercaptopurine, in plasma during intravenous administration. Clin Chem 1996; 42:380-86. (Pubitemid 26080922)
    • (1996) Clinical Chemistry , vol.42 , Issue.3 , pp. 380-386
    • Keuzenkamp-Jansen, C.W.1    Van Baal, J.M.2    De Abreu, R.A.3    De Jong, J.G.N.4    Zuiderent, R.5    Trijbels, J.M.F.6
  • 24
    • 76749144949 scopus 로고    scopus 로고
    • 6-thioguanine nucleotide (6-TGN) concentrations and efficacy of azathioprine (AZA) and mercaptopurine (MP) in inflammatory bowel disease: The metaza study
    • Gisbert JP. 6-thioguanine nucleotide (6-TGN) concentrations and efficacy of azathioprine (AZA) and mercaptopurine (MP) in inflammatory bowel disease: the metaza study. J Crohns and Colitis Supplements 2008; 2:7-15.
    • (2008) J Crohns and Colitis Supplements , vol.2 , pp. 7-15
    • Gisbert, J.P.1
  • 25
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Théorêt Y, Seidman EG. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000; 118:705-13. (Pubitemid 30171620)
    • (2000) Gastroenterology , vol.118 , Issue.4 , pp. 705-713
    • Dubinsky, M.C.1    Lamothe, S.2    Yang, H.Y.3    Targan, S.R.4    Sinnett, D.5    Theoret, Y.6    Seidman, E.G.7
  • 27
    • 0034771188 scopus 로고    scopus 로고
    • Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease
    • DOI 10.1136/gut.49.5.665
    • Lowry PW, Franklin CL, Weaver AL, Pike MG, Mays DC, Tremaine WJ, Lipsky JJ, Sandborn WJ. Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease. Gut 2001; 49:665-70. (Pubitemid 32989203)
    • (2001) Gut , vol.49 , Issue.5 , pp. 665-670
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3    Gennett, P.M.4    Mays, D.C.5    Tremaine, W.J.6    Lipsky, J.J.7    Sandborn, W.J.8
  • 28
  • 29
    • 0027164795 scopus 로고
    • Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience
    • Connell WR, Kamm MA, Ritchie JK, Lennard-Jones JE. Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut 1993; 34:1081-85. (Pubitemid 23245359)
    • (1993) Gut , vol.34 , Issue.8 , pp. 1081-1085
    • Connell, W.R.1    Kamm, M.A.2    Ritchie, J.K.3    Lennard-Jones, J.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.