Sulfuretin from heartwood of Rhus verniciflua triggers apoptosis through activation of Fas, Caspase-8, and the mitochondrial death pathway in HL-60 human leukemia cells

Journal of Cellular Biochemistry

Volumn 113, Issue 9, 2012, Pages 2835-2844

  Lee, Kyung Won ^a   Chung, Kyung Sook ^a,b   Seo, Ji Hyung ^a   Yim, Sung Vin ^a   Park, Hee Jun ^a   Choi, Jung Hye ^a,b   Lee, Kyung Tae ^a,b  

^a Kyung Hee University   (South Korea)

^b Sangji University   (South Korea)

Author keywords

APOPTOSIS; Bcl 2; Caspase 8; Fas; Rhus verniciflua; SULFURETIN

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FLAVONOID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BID; SULFURETIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HL 60; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKEMIA; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; POISON IVY; PRIORITY JOURNAL; RHUS VERNICIFLUA;

ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOFURANS; CASPASE 8; DNA FRAGMENTATION; FAS LIGAND PROTEIN; FLAVONOIDS; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; MITOCHONDRIA; RHUS;

TOXICODENDRON VERNICIFLUUM;

EID: 84863696107     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24158     Document Type: Article

References (40)

1. Bertram J, Peacock JW, Tan C, Mui AL, Chung SW, Gleave ME, Dedhar S, Cox ME, Ong CJ,. 2006. Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. Cancer Res 66: 4781-4788.
2. Bouchier-Hayes L, McBride S, van Geelen CM, Nance S, Lewis LK, Pinkoski MJ, Beere HM,. 2010. Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1. Cell Death Differ 17: 1034-1046.
3. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME,. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
4. Choi WC, Sminova Z, Kubasova I, Baryshnikov A,. 2002. Antitumor efficacy of the allergen-removed extract (ACM909Q) in Rhus verniciflua. Eur J Pharm Sci 17S: 78-79.
5. Choi J, Yoon BJ, Han YN, Lee KT, Ha J, Jung HJ, Park HJ,. 2003. Antirheumatoid arthritis effect of Rhus verniciflua and of the active component, sulfuretin. Planta Med 69: 899-904.
6. Choi WC, Lee JH, Lee EO,. 2006. Study on antiangiogenic and antitumor activities of processed Rhus verniciflua Stokes extract. Korean J Orient Physiol Pathol 20: 825-829.
7. Cragg GM, Newman DJ,. 2005. Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79.
8. Fulda S,. 2009. Caspase-8 in cancer biology and therapy. Cancer Lett 281: 128-133.
9. Gogvadze V, Orrenius S, Zhivotovsky B,. 2006. Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim Biophys Acta 1757: 639-647.
10. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J,. 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388: 190-195.
11. Jang HS, Kook SH, Son YO, Kim JG, Jeon YM, Jang YS, Choi KC, Kim J, Han SK, Lee KY, Park BK, Cho NP, Lee JC,. 2005. Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim Biophys Acta 1726: 309-316.
12. Jeon WK, Lee JH, Kim HK, Lee AY, Lee SO, Kim YS, Ryu SY, Kim SY, Lee YJ, Ko BS,. 2006. Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes. J Ethnopharmacol 106: 62-69.
13. Jung CH, Kim JH, Hong MH, Seog HM, Oh SH, Lee PJ, Kim GJ, Kim HM, Um JY, Ko SG,. 2007. Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide- induced RAW 264.7 macrophages. J Ethnopharmacol 110: 490-497.
14. Kaufmann SH, Earnshaw WC,. 2000. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 256: 42-49.
15. Kim R, Emi M, Tanabe K,. 2006. Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 57: 545-553.
16. Kim JH, Go HY, Jin DH, Kim HP, Hong MH, Chung WY, Park JH, Jang JB, Jung H, Shin YC, Kim SH, Ko SG,. 2008. Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines. Cancer Lett 265: 197-205.
17. Kim HR, Kim KS, Jung HS, Choi WC, Eo WK, Cheon SH,. 2010. A case of recurred hepatocellular carcinoma refractory to doxorubicin after liver transplantation showing response to herbal medicine product, Rhus verniciflua Stokes extract. Integr Cancer Ther 9: 100-104.
18. Koning AJ, Lum PY, Williams JM, Wright R,. 1993. DiOC6 staining reveals organelle structure and dynamics in living yeast cells. Cell Motil Cytoskeleton 25: 111-128.
19. Kook SH, Son YO, Chung SW, Lee SA, Kim JG, Jeon YM, Lee JC,. 2007. Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. Apoptosis 12: 1289-1298.
20. Kumar S,. 2007. Caspase function in programmed cell death. Cell Death Differ 14: 32-43.
21. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandenabeele P,. 2007. Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14: 44-55.
22. Lee KW, Jung HJ, Park HJ, Kim DG, Lee JY, Lee KT,. 2005. Beta- D -xylopyranosyl-(1->3)-beta- D -glucuronopyranosyl echinocystic acid isolated from the roots of Codonopsis lanceolata induces caspase-dependent apoptosis in human acute promyelocytic leukemia HL-60 cells. Biol Pharm Bull 28: 854-859.
23. Lee SH, Choi WC, Yoon SW,. 2009a. Impact of standardized Rhus verniciflua stokes extract as complementary therapy on metastatic colorectal cancer: A Korean single-center experience. Integr Cancer Ther 8: 148-152.
24. Lee SH, Kim KS, Choi WC, Yoon SW,. 2009b. Successful outcome of advanced pulmonary adenocarcinoma with malignant pleural effusion by the standardized Rhus verniciflua stokes extract: A case study. Explore (NY) 5: 242-244.
25. Lee SH, Choi WC, Kim KS, Park JW, Yoon SW,. 2010a. Shrinkage of gastric cancer in an elderly patient who received Rhus verniciflua Stokes extract. J Altern Complement Med 16: 497-500.
26. Lee SK, Jung HS, Eo WK, Lee SY, Kim SH, Shim BS,. 2010b. Rhus verniciflua Stokes extract as a potential option for treatment of metastatic renal cell carcinoma: Report of two cases. Ann Oncol 21: 1383-1385.
27. Mahalingam D, Szegezdi E, Keane M, de Jong S, Samali A,. 2009. TRAIL receptor signalling and modulation: Are we on the right TRAIL? Cancer Treat Rev 35: 280-288.
28. Opferman JT, Korsmeyer SJ,. 2003. Apoptosis in the development and maintenance of the immune system. Nat Immunol 4: 410-415.
29. Ott M, Norberg E, Zhivotovsky B, Orrenius S,. 2009. Mitochondrial targeting of tBid/Bax: A role for the TOM complex? Cell Death Differ 16: 1075-1082.
30. Park KY, Jung GO, Lee KT, Choi J, Choi MY, Kim GT, Jung HJ, Park HJ,. 2004. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. J Ethnopharmacol 90: 73-79.
31. Rossi D, Gaidano G,. 2003. Messengers of cell death: Apoptotic signaling in health and disease. Haematologica 88: 212-218.
32. Samoszuk M, Tan J, Chorn G,. 2005. The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. BMC Complement Altern Med 5: 1-5.
33. Shin JS, Park YM, Choi JH, Park HJ, Shin MC, Lee YS, Lee KT,. 2010. Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. Int Immunopharmacol 10: 943-950.
34. Son YO, Lee KY, Lee JC, Jang HS, Kim JG, Jeon YM, Jang YS,. 2005. Selective antiproliferative and apoptotic effects of flavonoids purified from Rhus verniciflua Stokes on normal versus transformed hepatic cell lines. Toxicol Lett 155: 115-125.
35. Suhara T, Kim HS, Kirshenbaum LA, Walsh K,. 2002. Suppression of Akt signaling induces Fas ligand expression: Involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol Cell Biol 22: 680-691.
36. Wang C, Youle RJ,. 2009. The role of mitochondria in apoptosis. Annu Rev Genet 43: 95-118.
37. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ,. 2001. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730.
38. Yoshimoto Y, Kawada M, Ikeda D, Ishizuka M,. 2005. Involvement of doxorubicin-induced Fas expression in the antitumor effect of doxorubicin on Lewis lung carcinoma in vivo. Int Immunopharmacol 5: 281-288.
39. Zhai D, Luciano F, Zhu X, Guo B, Satterthwait AC, Reed JC,. 2005. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J Biol Chem 280: 15815-15824.
40. Zhang X, Tang N, Hadden TJ, Rishi AK,. 2011. Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta 1813: 1978-1986.