Modeling HIV-1 drug resistance as episodic directional selection

PLoS Computational Biology

Volumn 8, Issue 5, 2012, Pages

  Murrell, Ben ^a,b   de Oliveira, Tulio ^c,d   Seebregts, Chris ^a,e   Kosakovsky Pond, Sergei L ^f   Scheffler, Konrad ^b,f  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF KWAZULU NATAL   (South Africa)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRALS; CODON SEQUENCES; DIRECTIONAL SELECTION; DIVERSIFYING SELECTIONS; DRUG-RESISTANCE; EVOLUTIONARY MODELS; MODELING HIV; PROPERTY; PROTEIN SEQUENCES; SITE-SPECIFIC;

DRUG THERAPY;

INTEGRASE; PROTEINASE; RNA DIRECTED DNA POLYMERASE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ANTIVIRAL RESISTANCE; ARTICLE; CODON; CONTROLLED STUDY; DIRECTIONAL SELECTION; DIVERSIFYING SELECTION; ENZYME LOCALIZATION; HUMAN IMMUNODEFICIENCY VIRUS 1; INTERMETHOD COMPARISON; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; NONHUMAN; PROCESS MODEL; PROTEIN TARGETING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; BIOLOGICAL MODEL; COMPUTER SIMULATION; DRUG EFFECT; EVOLUTION; GENETIC SELECTION; GENETIC VARIABILITY; GENETICS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; BIOLOGICAL EVOLUTION; COMPUTER SIMULATION; DRUG RESISTANCE, VIRAL; EVOLUTION, MOLECULAR; GENETIC VARIATION; HIV-1; MODELS, GENETIC; SELECTION, GENETIC;

EID: 84863683678     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002507     Document Type: Article

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