Lyophilised reconstituted human platelets increase thrombus formation in a clinical ex vivo model of deep arterial injury

Thrombosis and Haemostasis

Volumn 108, Issue 1, 2012, Pages 176-182

  Joshi, Nikhil Vilas ^a   Raftis, Jennifer B ^a   Lucking, Andrew J ^a   Hunter, Amanda H ^a   Millar, Mike ^b   Fitzpatrick, Mike ^c   Feuerstein, Giora Z ^c   Newby, David E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Cellphire Inc   (United States)

Author keywords

Bleeding disorders; Haemostasis; Lyophilised human platelets; Platelet substitutes

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; BLOOD CLOTTING; FLUORESCENCE MICROSCOPY; FREEZE DRYING; HEMOSTASIS; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SHEAR RATE; SWINE; THROMBOCYTE; THROMBOCYTE FREE PLASMA; THROMBUS; TRANSMISSION ELECTRON MICROSCOPY;

ADOLESCENT; ADULT; ANIMALS; ARTERIES; BLOOD COAGULATION; BLOOD PLATELETS; FREEZE DRYING; HEMORRHAGE; HEMOSTATIC TECHNIQUES; HUMANS; MODELS, ANIMAL; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SWINE; YOUNG ADULT;

EID: 84863673376     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-02-0059     Document Type: Article

References (28)

1. Stroncek DF, Rebulla P. Platelet transfusions. Lancet 2007; 370: 427-438.
2. Blajchman M. Substitutes and alternatives to platelet transfusions in thrombocytopenic patients. J Thromb Haemost 2003; 1: 1637-1641.
3. Holme S, Heaton A. In vitro platelet ageing at 22 degrees C is reduced compared to in vivo ageing at 37 degrees C. Br J Haematol 1995; 91: 212-218.
4. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: a reassessment. J Trauma 1995; 38: 185-193.
5. Holcomb JB, McMullin NR, Pearse L, et al. Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004. Ann Surg 2007; 245: 986-991.
6. Heal JM, Blumberg N. Optimizing platelet transfusion therapy. Blood Rev 2004; 18: 149-165.
7. Blajchman MA. Novel platelet products, substitutes and alternatives. Transfus Clin Biol 2001; 8: 267-271.
8. Bode AP, Fischer TH. Lyophilized platelets: fifty years in the making. Artif Cells Blood Substit Immobil Biotechnol 2007; 35: 125-133.
9. Fitzpatrick G, Agashe H, Dee J. Trehalose stabilized freeze dried human platelets, Thrombosomes, reduce blood loss in thrombocytopenic rabbit ear bleed model by as much as 89.5%. International Society of Blood Transfusion. Vox Sanguinis 2010; 99 (Suppl 1): Abstract P-0452.
10. Fitzpatrick M, Dee J, Koh A, et al. Characterization of a novel lyophilized platelet derivative (LPDH) which exhibits in vitro hemostatic function, and in vivo safety and efficacy in trauma induced uncontrolled bleeding in nonhuman primate. ASH Annual Meeting Abstracts 2011. Blood 2011; 118: Abstract 719.
11. Zafar MU, Farkouh ME, Osende J, et al. Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients. Thromb Haemost 2007; 97: 487-492.
12. Wahlander K, Eriksson-Lepkowska M, Nystrom P, et al. Antithrombotic effects of ximelagatran plus acetylsalicylic acid (ASA) and clopidogrel plus ASA in a human ex vivo arterial thrombosis model. Thromb Haemost 2006; 95: 447-453.
13. Lucking AJ, Chelliah R, Trotman AD, et al. Characterisation and reproducibility of a human ex vivo model of thrombosis. Thromb Res 2010; 126: 431-435.
14. Vilahur G, Pena E, Padro T, et al. Protein disulphide isomerase-mediated LA419-NO release provides additional antithrombotic effects to the blockade of the ADP receptor. Thromb Haemost 2007; 97: 650-657.
15. Chelliah R, Lucking A, Tattersall L, et al. P selectin antagonism reduces thrombus formation in humans. J Thromb Haemost 2009; 7: 1915-1919.
16. Lucking A, Visvanathan A, Philippou H, et al. Effect of the small molecule plasminogen activator inhibitor 1 (PAI 1) inhibitor, PAI 749, in clinical models of fibrinolysis. J Thromb Haemost 2010; 8: 1333-1339.
17. Lucking AJ, Lundback M, Mills NL, et al. Diesel exhaust inhalation increases thrombus formation in man. Eur Heart J 2008; 29: 3043-3051.
18. Read MS, Reddick RL, Bode AP, et al. Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion. Proc Natl Acad Sci USA 1995; 92: 397-401.
19. Read MS, Bode AP. Platelet storage: efforts to extend the shelf life of platelet concentrates. Mol Med Today 1995; 1: 322-328.
20. Hawksworth J, Elster E, Fryer D, et al. Evaluation of lyophilized platelets as an infusible hemostatic agent in experimental non compressible hemorrhage in swine. J Thromb Haemost 2009; 7: 1663-1671.
21. Bode A, Blajchman M, Bardossy L, et al. Hemostatic properties of human lyophilized platelets in a thrombocytopenic rabbit model and a simulated bleeding time device. Blood 1994; 84 (Suppl 1): 464a.
22. Bode AP, Read MS, Reddick RL. Activation and adherence of lyophilized human platelets on canine vessel strips in the Baumgartner perfusion chamber* 1,* 2,* 3. J Lab Clin Med 1999; 133: 200-211.
23. Valeri C, MacGregor H, Barnard M, et al. Survival of baboon biotin X N hydroxysuccinimide and 111In oxine labelled autologous fresh and lyophilized reconstituted platelets. Vox Sang 2005; 88: 122-129.
24. Blajchman MA. Substitutes for success. Nat Med 1999; 5: 17-18.
25. Lee DH, Blajchman MA. Novel platelet products and substitutes. Transfus Med Rev 1998; 12: 175-187.
26. Dangas G, Badimon JJ, Coller BS, et al. Administration of abciximab during percutaneous coronary intervention reduces both ex vivo platelet thrombus formation and fibrin deposition: implications for a potential anticoagulant effect of abciximab. Arterioscl Thromb Vasc Biol 1998; 18: 1342.
27. Fischer TH, Merricks EP, Bode AP, et al. Thrombus formation with rehydrated, lyophilized platelets. Hematology 2002; 7: 359-369.
28. Bode AP, Read MS. Lyophilized platelets: continued development. Transfusion Sci 2000; 22: 99-105.