Administration of abciximab during percutaneous coronary intervention reduces both ex vivo platelet thrombus formation and fibrin deposition: Implications for a potential anticoagulant effect of abciximab

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 8, 1998, Pages 1342-1349

  Dangas, George ^a   Badimon, Juan J ^a   Coller, Barry S ^a   Fallon, John T ^a   Sharma, Samin K ^a   Hayes, Richard M ^a   Meraj, Perwaiz ^a   Ambrose, John A ^a   Marmur, Jonathan D ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI HOSPITAL   (United States)

Author keywords

Angioplasty; Platelets; Thrombosis

Indexed keywords

ABCIXIMAB;

ADULT; ANTICOAGULATION; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CLINICAL ARTICLE; CORONARY ARTERY DILATATION; CORONARY ARTERY OBSTRUCTION; DRUG EFFECT; DRUG MECHANISM; FEMALE; FIBRIN FORMATION; HUMAN; MALE; PRIORITY JOURNAL; STIMULUS RESPONSE; THROMBOCYTE AGGREGATION; THROMBOGENESIS; TRANSLUMINAL CORONARY ANGIOPLASTY;

EID: 0031845763     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.8.1342     Document Type: Article

References (16)

1. Femandez-Ortiz A, Badimon JJ, Falk E, Fusler V, Meyer B, Mailhac A, Weng D, Shah PK, Badimon L. Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture. J Am Coll Cardiol. 1994;23:1562-1569.
2. Marmur JD, Thiruvikraman SV, Fyfe BS, Guha A, Sharma SK, Ambrose JA, Fallon JT, Nemerson Y, Taubman MB. Identification of active tissue factor in human coronary atheroma. Circulation. 1996;94:1226-1232.
3. Kirchhofer D, Tschopp B, Steiner B, Baumgartner HR. Role of collagenadherent platelets in mediating fibrin formation in flowing whole blood. Blood. 1995;86:3815-3822.
4. Kumar R, Beguin S, Hemker HC. The influence of fibrinogen and fibrin on thrombin generation: evidence for feedback activation of the clotting system by clot bound thrombin. Thromb Haemost. 1994;72:713-721.
5. Toschi V, Gallo R, Lettino M, Fallon JT, Gertz SD, Fernandez-Ortiz A, Chesebro JH, Badimon L, Nemerson Y, Fuster V, Badimon JJ. Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation. 1997;95:594-599.
6. Lincoff AM, Poprna JJ, Ellis SG, Hacker JA, Topol EJ. Abrupt vessel closure complicating coronary angioplasty: clinical, angiographie and therapeutic profile. J Am Coll Cardiol. 1992;19:926-935.
7. Dangas G, Fuster V. Management of restenosis after coronary intervention. Am Heart J. 1996;132:428-436.
8. Coller BS, Anderson K, Weisman HF. New antiplatelet agents: platelet GP IIb/IIIa antagonists. Thromb Haemost. 1995;74:301-308.
9. Coller BS. A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex. J Clin Invest. 1985;76:101-108.
10. Tcheng JE. Glycoprotein IIb/IIIa receptor inhibitors: putting the EPIC, IMPACT II, RESTORE, and EPILOG trials into perspective. Am J Cardiol. 1996;78(suppl 3A):35-40.
11. Konstantopoulos K, Kamat SG, Schafer AI, Banez EI, Jordon R, Kleiman NS, Hellums D. Shear-induced platelet aggregation is inhibited by in vivo infusion of an anti-glycoprotein IIb/IIIa antibody fragment, abciximab, in patients undergoing coronary angioplasty. Circulation. 1995;91:1427-1431.
12. Turner NA, Moake JL, Kamat SG, Schafer AI, Kleiman NS, Jordan R, McIntire LV. Comparative real-time effects on platelet adhesion and aggregation under flowing conditions of in vivo aspirin, heparin, and monoclonal antibody fragment against glycoprotein IIb/IIIa. Circulation. 1995;91:1354-1362.
13. Reverter JC, Beguin S, Kessels H, Kumar R, Coller BS. Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody: potential implications for the effects of abciximab treatment on acute thrombosis and "clinical restenosis." J Clin Invest. 1996;98:863-874.
14. Badimon L, Turitto V, Rosemark JA, Badimon JJ, Fuster V. Characterization of a tubular flow chamber for studying platelet interaction with biologic and prosthetic materials: deposition of indium 111-labeled platelets on collagen, subendothelium, and expanded polytetrafluoroethylene. J Lab Clin Med. 1987;110:706-718.
15. Slack SM, Turitto VT. Flow chambers and their standardization for use in studies of thrombosis. Thromb Haemost. 1994;72:777-781.
16. Lacoste L, Lam JYT, Hung J, Letchakovski G, Solymoss CB, Waters D. Hyperlipidemia and coronary disease: correction of the increased thrombogenic potential with cholesterol reduction. Circulation. 1995;92:3172-3177.