Characterisation and reproducibility of a human ex vivo model of thrombosis

Thrombosis Research

Volumn 126, Issue 5, 2010, Pages 431-435

  Lucking, Andrew J ^a   Chelliah, Rajesh ^a   Trotman, Alexander D ^a   Connolly, Thomas M ^b   Feuerstein, Giora Z ^b   Fox, Keith A ^a   Boon, Nicholas A ^a   Badimon, Juan J ^c   Newby, David E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b PFIZER INC   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Ex Vivo; Platelet; Thrombosis

Indexed keywords

FIBRIN; PADGEM PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; EXTRACORPOREAL CIRCULATION; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SHEAR RATE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOSIS; TUNICA MEDIA;

ADOLESCENT; ADULT; ANIMALS; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; REPRODUCIBILITY OF RESULTS; SWINE; THROMBOSIS; YOUNG ADULT;

EID: 78149286116     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2010.06.030     Document Type: Article

References (16)

1. R.J. Leadley Jr., L. Chi, S.S. Rebello, and A. Gagnon Contribution of in vivo models of thrombosis to the discovery and development of novel antithrombotic agents J Pharmacol Toxicol Meth 43 2 2000 101 116
2. M.H. Kroll, J.D. Hellums, L.V. McIntire, A.I. Schafer, and J.L. Moake Platelets and shear stress Blood 88 5 1996 1525 1541
3. E.I. Lev, R. Patel, A. Karim, A. Kleiman, J.J. Badimon, and N.S. Kleiman Anti-thrombotic effect of bivalirudin compared with eptifibatide and unfractionated heparin in diabetic patients: an ex vivo human study Thromb Haemost 95 3 2006 441 446
4. K. Wahlander, M. Eriksson-Lepkowska, P. Nystrom, U.G. Eriksson, T.C. Sarich, and J.J. Badimon Antithrombotic effects of ximelagatran plus acetylsalicylic acid (ASA) and clopidogrel plus ASA in a human ex vivo arterial thrombosis model Thromb Haemost 95 3 2006 447 453
5. M.U. Zafar, M.E. Farkouh, J. Osende, D. Shimbo, S. Palencia, and J. Crook Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients Thromb Haemost 97 3 2007 487 492
6. M.U. Zafar, D.A. Vorchheimer, J. Gaztanaga, M. Velez, D. Yadegar, and P.R. Moreno Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber Thromb Haemost 98 4 2007 883 888
7. L. Badimon, J.J. Badimon, A. Galvez, J.H. Chesebro, and V. Fuster Influence of arterial damage and wall shear rate on platelet deposition. Ex vivo study in a swine model Arteriosclerosis 6 3 1986 312 320
8. L. Badimon, V. Turitto, J.A. Rosemark, J.J. Badimon, and V. Fuster Characterization of a tubular flow chamber for studying platelet interaction with biologic and prosthetic materials: deposition of indium 111-labeled platelets on collagen, subendothelium, and expanded polytetrafluoroethylene J Lab Clin Med 110 6 1987 706 718
9. A. Fernandez-Ortiz, J.J. Badimon, E. Falk, V. Fuster, B. Meyer, and A. Mailhac Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture J Am Coll Cardiol 23 7 1994 1562 1569
10. G. Dangas, J.J. Badimon, B.S. Coller, J.T. Fallon, S.K. Sharma, and R.M. Hayes Administration of abciximab during percutaneous coronary intervention reduces both ex vivo platelet thrombus formation and fibrin deposition: implications for a potential anticoagulant effect of abciximab Arterioscler Thromb Vasc Biol 18 8 1998 1342 1349
11. S.A. Harding, J. Sarma, J.N. Din, P.M. Maciocia, D.E. Newby, and K.A. Fox Clopidogrel reduces platelet-leucocyte aggregation, monocyte activation and RANTES secretion in type 2 diabetes mellitus Heart 92 9 2006 1335 1337
12. S.A. Harding, J.N. Din, J. Sarma, A. Jessop, M. Weatherall, and K.A. Fox Flow cytometric analysis of circulating platelet-monocyte aggregates in whole blood: methodological considerations Thromb Haemost 98 2 2007 451 456
13. J.M. Bland, and D.G. Altman Statistical methods for assessing agreement between two methods of clinical measurement Lancet 1 8476 1986 307 310
14. P.L. Giesen, U. Rauch, B. Bohrmann, D. Kling, M. Roque, and J.T. Fallon Blood-borne tissue factor: another view of thrombosis Proc Natl Acad Sci USA 96 5 1999 2311 2315
15. S. Gokhale, D. Rosen, N. Sneige, L.K. Diaz, E. Resetkova, and A. Sahin Assessment of two automated imaging systems in evaluating estrogen receptor status in breast carcinoma Appl Immunohistochem Mol Morphol 15 4 2007 451 455
16. S. Falati, P. Gross, G. Merrill-Skoloff, B.C. Furie, and B. Furie Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse Nat Med 8 10 2002 1175 1181