JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced postinflammatory irritable bowel syndrome through reducing colonic EC cell hyperplasia and serotonin availability in rats

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Qin, Hong Yan ^a   Xiao, Hai Tao ^a   Leung, Fung Ping ^a   Yang, Zhi Jun ^a   Wu, Justin C Y ^b   Sung, Joseph J Y ^b   Xu, Hong Xi ^c   Tong, Xu Dong ^d   Bian, Zhao Xiang ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b Prince of Wales Hospital   (Hong Kong)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HERBACEOUS AGENT; INTERLEUKIN 10; INTERLEUKIN 6; JCM 16021; SEROTONIN; TRINITROBENZENESULFONIC ACID; TRYPTOPHAN HYDROXYLASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DENSITY; CELL HYPERPLASIA; CHINESE MEDICINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ELECTROMYOGRAM; ENTEROCHROMAFFIN CELL; HELPER CELL; HORMONE RELEASE; HYPERALGESIA; IRRITABLE COLON; LOCOMOTION; MALE; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; POSTINFLAMMATORY IRRITABLE BOWEL SYNDROME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT DURATION; WITHDRAWAL REFLEX;

EID: 84863672084     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/239638     Document Type: Article

References (56)

1. Dunlop S. P., Jenkins D., Neal K. R., Spiller R. C., Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS Gastroenterology 2003 125 6 1651 1659 (Pubitemid 37500429)
2. Gwee K. A., Leong Y. L., Graham C., McKendrick M. W., Collins S. M., Walters S. J., Underwood J. E., Read N. W., The role of psychological and biological factors in postinfective gut dysfunction Gut 1999 44 3 400 406 (Pubitemid 29119338)
3. Yao X., Yang Y. S., Cui L. H., Zhao K. B., Zhang Z. H., Peng L. H., Guo X., Sun G., Shang J., Wang W. F., Feng J., Huang Q., Subtypes of irritable bowel syndrome on Rome III criteria: a multicenter study Journal of Gastroenterology and Hepatology 2012 27 4 760 765
4. Spiller R., Garsed K., Postinfectious irritable bowel syndrome Gastroenterology 2009 136 6 1979 1988
5. Price D. D., Craggs J. G., Zhou Q., Verne G. N., Perlstein W. M., Robinson M. E., Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors: evidence from human psychophysics, animal models, and neuroimaging NeuroImage 2009 47 3 995 1001
6. Stacher G., Christensen J., Visceral hypersensitivity in irritable bowel syndrome: a summary review Digestive Diseases and Sciences 2006 51 3 440 445
7. Azpiroz F., Bouin M., Camilleri M., Mayer E. A., Poitras P., Serra J., Spiller R. C., Mechanisms of hypersensitivity in IBS and functional disorders Neurogastroenterology and Motility 2007 19 1 62 88 (Pubitemid 46058983)
8. Bearcroft C. P., Perrett D., Farthing M. J. G., Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study Gut 1998 42 1 42 46 (Pubitemid 28228386)
9. Kerckhoffs A. P. M., Ter Linde J. J. M., Akkermans L. M. A., Samsom M., Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients Neurogastroenterology and Motility 2008 20 8 900 907 (Pubitemid 352019709)
10. Mawe G. M., Coates M. D., Moses P. L., Review article: intestinal serotonin signalling in irritable bowel syndrome Alimentary Pharmacology and Therapeutics 2006 23 8 1067 1076 (Pubitemid 43779345)
11. Houghton L. A., Atkinson W., Whitaker R. P., Whorwell P. J., Rimmer M. J., Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome Gut 2003 52 5 663 670 (Pubitemid 36528867)
12. Park J. H., Rhee P. L., Kim G., Lee J. H., Kim Y. H., Kim J. J., Rhee J. C., Song S. Y., Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome Neurogastroenterology and Motility 2006 18 7 539 546 (Pubitemid 43855807)
13. Greenwood-Van Meerveld B., Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity Neurogastroenterology and Motility 2007 19 2 13 18 (Pubitemid 47039147)
14. Thibault K., Van Steenwinckel J., Brisorgueil M. J., Fischer J., Hamon M., Calvino B., Conrath M., Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat Pain 2008 140 2 305 322
15. Choi Y. D., Sung T. S., Kim H. J., La J. H., Kim T. W., Yang I. S., Increased 5-hydroxytryptamine mediates post-inflammatory visceral hypersensitivity via the 5-hydroxytryptamine 3 receptor in rats Digestive Diseases and Sciences 2008 53 11 2909 2916
16. Chen S., Li J., Zhang L., Dong X., Gao W., Mo J., Chen H., Xiao S., Li Y., 5-HT3 receptors mediate the time-dependent vagal afferent modulation of nociception during chronic food allergen-sensitized visceral hyperalgesia in rats Neurogastroenterology and Motility 2009 21 11 1222 e113
17. Cenac N., Altier C., Motta J. P., D'Aldebert E., Galeano S., Zamponi G. W., Vergnolle N., Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity Gut 2010 59 4 481 488
18. Ohta T., Ikemi Y., Murakami M., Imagawa T., Otsuguro K. I., Ito S., Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons Journal of Physiology 2006 576 3 809 822 (Pubitemid 44637885)
19. Sugiura T., Bielefeldt K., Gebhart G. F., TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation Journal of Neuroscience 2004 24 43 9521 9530 (Pubitemid 39441506)
20. Kim D. Y., Camilleri M., Serotonin: a mediator of the brain-gut connection American Journal of Gastroenterology 2000 95 10 2704 2709
21. Gershon M. D., Tack J., The serotonin signaling system: from basic understanding to drug development for functional GI disorders Gastroenterology 2007 132 1 397 414 (Pubitemid 46127672)
22. Bertrand P. P., Real-time measurement of serotonin release and motility in guinea pig ileum Journal of Physiology 2006 577 2 689 704 (Pubitemid 44810537)
23. Hansen M. B., Neurohumoral control of gastrointestinal motility Physiological Research 2003 52 1 1 30 (Pubitemid 36356256)
24. Moore B. A., Sharkey K. A., Mantle M., Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine American Journal of Physiology-Gastrointestinal and Liver Physiology 1996 270 6 G1001 G1009
25. Grndahl M. L., Jensen G. M., Nielsen C. G., Skadhauge E., Olsen J. E., Hansen M. B., Secretory pathways in Salmonella Typhimurium-induced fluid accumulation in the porcine small intestine Journal of Medical Microbiology 1998 47 2 151 157 (Pubitemid 28041259)
26. Kordasti S., Sjvall H., Lundgren O., Svensson L., Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea Gut 2004 53 7 952 957 (Pubitemid 38824151)
27. Spiller R. C., Jenkins D., Thornley J. P., Hebden J. M., Wright T., Skinner M., Neal K. R., Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome Gut 2000 47 6 804 811
28. Wang H., Steeds J., Motomura Y., Deng Y., Verma-Gandhu M., El-Sharkawy R. T., McLaughlin J. T., Grencis R. K., Khan W. I., CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection Gut 2007 56 7 949 957 (Pubitemid 46999078)
29. Motomura Y., Ghia J. E., Wang H., Akiho H., El-Sharkawy R. T., Collins M., Wan Y., McLaughlin J. T., Khan W. I., Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments Gut 2008 57 4 475 481 (Pubitemid 351442531)
30. Coates M. D., Mahoney C. R., Linden D. R., Sampson J. E., Chen J., Blaszyk H., Crowell M. D., Sharkey K. A., Gershon M. D., Mawe G. M., Moses P. L., Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome Gastroenterology 2004 126 7 1657 1664 (Pubitemid 38736329)
31. Costedio M. M., Hyman N., Mawe G. M., Serotonin and its role in colonic function and in gastrointestinal disorders Diseases of the Colon and Rectum 2007 50 3 376 388 (Pubitemid 46394454)
32. Spiller R., Serotonin and GI clinical disorders Neuropharmacology 2008 55 6 1072 1080
33. Simrén M., Axelsson J., Gillberg R., Abrahamsson H., Svedlund J., Bjrnsson E. S., Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors American Journal of Gastroenterology 2002 97 2 389 396 (Pubitemid 34160766)
34. Hulisz D., The burden of illness of irritable bowel syndrome: current challenges and hope for the future Journal of Managed Care Pharmacy 2004 10 4 299 309
35. Du Pont A. W., Postinfectious irritable bowel syndrome Clinical Infectious Diseases 2008 46 4 594 599 (Pubitemid 351263502)
36. Hungin A. P. S., Chang L., Locke G. R., Dennis E. H., Barghout V., Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact Alimentary Pharmacology and Therapeutics 2005 21 11 1365 1375 (Pubitemid 40813683)
37. Chang F. Y., Lu C. L., Treatment of Irritable Bowel Syndrome Using Complementary and Alternative Medicine Journal of the Chinese Medical Association 2009 72 6 294 300
38. Shen Y. H. A., Nahas R., Complementary and alternative medicine for treatment of irritable bowel syndrome Canadian Family Physician 2009 55 2 143 148
39. Sung J. J. Y., Bian Z. X., Wu J. C. Y., Ziea E. T., Suen B. Y., Leung W. K., Herbal medicine versus hyosine in the treatment of irritable bowelsyndrome: a double-blinded randomized study Gut 2007 56 supplement 3 A338
40. Bian Z. X., Zhang M., Han Q. B., Xu H. X., Sung J. J. Y., Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats World Journal of Gastroenterology 2010 16 7 837 845
41. Qin H. Y., Wu J. C. Y., Tong X. D., Sung J. J. Y., Xu H. X., Bian Z. X., Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome Journal of Gastroenterology 2011 46 2 164 174
42. Liebregts T., Adam B., Bertel A., Jones S., Schulze J., Enders C., Sonnenborn U., Lackner K., Holtmann G., Effect of E. coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model Neurogastroenterology and Motility 2005 17 3 410 414 (Pubitemid 40768913)
43. Al-Chaer E. D., A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development Gastroenterology 2000 119 5 1276 1285
44. Tammpere A., Brusberg M., Axenborg J., Hirsch I., Larsson H., Lindstrm E., Evaluation of pseudo-affective responses to noxious colorectal distension in rats by manometric recordings Pain 2005 116 3 220 226 (Pubitemid 40957125)
45. Li Z., Zhang X. J., Xu H. X., Sung J. J. Y., Bian Z. X., Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats European Journal of Pharmacology 2009 606 13 199 204
46. Grimelius L., Silver stains demonstrating neuroendocrine cells Biotechnic and Histochemistry 2004 79 1 37 44 (Pubitemid 38997103)
47. Qi S. D., Tian S. L., Xu H. X., Sung J. J. Y., Bian Z. X., Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection Analytical and Bioanalytical Chemistry 2009 393 8 2059 2066
48. Wade P. R., Westfall J. A., Ulstructure of enterochromaffin cells and associated neural and vascular elements in the mouse duodenum Cell and Tissue Research 1985 241 3 557 563 (Pubitemid 15024601)
49. Fujimiya M., Okumiya K., Kuwahara A., Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure Histochemistry and Cell Biology 1997 108 2 105 113 (Pubitemid 27362336)
50. Qin H. Y., Luo J. L., Qi S. D., Xu H. X., Sung J. J. Y., Bian Z. X., Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon European Journal of Pharmacology 2010 647 13 75 83
51. Bertrand P. P., Bertrand R. L., Serotonin release and uptake in the gastrointestinal tract Autonomic Neuroscience: Basic and Clinical 2010 153 1-2 47 57
52. Wheatcroft J., Wakelin D., Smith A., Mahoney C. R., Mawe G., Spiller R., Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction Neurogastroenterology and Motility 2005 17 6 863 870 (Pubitemid 41748282)
53. Atkinson W., Lockhart S., Whorwell P. J., Keevil B., Houghton L. A., Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome Gastroenterology 2006 130 1 34 43 (Pubitemid 43049833)
54. Dunlop S. P., Coleman N. S., Blackshaw E., Perkins A. C., Singh G., Marsden C. A., Spiller R. C., Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome Clinical Gastroenterology and Hepatology 2005 3 4 349 357 (Pubitemid 40488343)
55. Ortiz Lucas M., Saz Peir P., Sebastin Domingo J. J., Irritable bowel syndrome immune hypothesis. Part two: the role of cytokines Revista Espanola de Enfermedades Digestivas 2010 102 12 711 717
56. Wang L., Zhou G. B., Liu P., Song J. H., Liang Y., Yan X. J., Xu F., Wang B. S., Mao J. H., Shen Z. X., Chen S. J., Chen Z., Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia Proceedings of the National Academy of Sciences of the United States of America 2008 105 12 4826 4831 (Pubitemid 351753831)