5-HT3 receptors mediate the time-dependent vagal afferent modulation of nociception during chronic food allergen-sensitized visceral hyperalgesia in rats

Neurogastroenterology and Motility

Volumn 21, Issue 11, 2009, Pages

  Chen, S ^a   Li, J ^b   Zhang, L ^a   Dong, X ^a   Gao, W ^a   Mo, J ^a   Chen, H ^b   Xiao, S ^a   Li, Y ^c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

5 HT3 receptors; Food allergen; Vagal afferents; Visceral hyperalgesia

Indexed keywords

CAPSAICIN; FOOD ALLERGEN; GRANISETRON; LIDOCAINE; MESSENGER RNA; SEROTONIN 3 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; COLON DILATATION; DOSE TIME EFFECT RELATION; ELECTRODE; HYPERALGESIA; IMPLANTATION; MALE; MAST CELL; MEDIATOR; MODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SPRAGUE DAWLEY RAT; VAGOTOMY; VAGUS NERVE STIMULATION; VISCERAL PAIN;

ALLERGENS; ANIMALS; BALLOON DILATION; FOOD HYPERSENSITIVITY; GRANISETRON; HYPERALGESIA; INTESTINAL MUCOSA; MALE; MAST CELLS; NEURONS, AFFERENT; PAIN; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SEROTONIN ANTAGONISTS; TIME FACTORS; VAGOTOMY; VAGUS NERVE;

EID: 70349661607     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01335.x     Document Type: Article

References (33)

1. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006 130 : 1377 1390.
2. Anand P, Aziz Q, Willert R, van Oudenhove L. Peripheral and central mechanisms of visceral sensitization in man. Neurogastroenterol Motil 2007 19 : 29 46.
3. Zar S, Kumar D, Benson MJ. Review article: food hypersensitivity and irritable bowel syndrome. Aliment Pharmacol Ther 2001 15 : 439 449.
4. Andrews PL, Sanger GJ. Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction. Curr Opin Pharmacol 2002 2 : 650 656.
5. Grundy D. Neuroanatomy of visceral nociception: vagal and splanchnic afferent. Gut 2002 51 : i2 5.
6. 3 receptors in a rat model of delayed stress-induced visceral hyperalgesia. Pain 2007 130 : 56 65.
7. Chen SL, Wu XY, Cao ZJ et al. Subdiaphragmatic vagal afferent nerves modulate visceral pain. Am J Physiol Gastrointest Liver Physiol 2008 294 : G1441 9.
8. Gschossmann JM, Mayer EA, Miller JC, Raybould HE. Subdiaphragmatic vagal afferent innervation in activation of an opioidergic antinociceptive system in response to colorectal distension in rats. Neurogastroenterol Motil 2002 14 : 403 408.
9. Smart HL, Atkinson M. Abnormal vagal function in irritable bowel syndrome. Lancet 1987 ii : 475 478.
10. Elsenbruch S, Orr WC. Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses. Am J Gastroenterol 2001 96 : 460 466.
11. Spaziani R, Bayati A, Redmond K et al. Vagal dysfunction in irritable bowel syndrome assessed by rectal distension and baroreceptor sensitivity. Neurogastroenterol Motil 2008 20 : 336 342.
12. Spiller R. Serotonin and GI clinical disorders. Neuropharmacology 2008 55 : 1072 1080.
13. 1 receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats. Gastroenterology 2000 119 : 1267 1275.
14. Greenwood-van Meerveld B. Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity. Neurogastroenterol Motil 2007 19 : 13 8.
15. Andresen V, Montori VM, Keller J, West CP, Layer P, Camilleri M. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol 2008 6 : 545 555.
16. Matsueda K, Harasawa S, Hongo M, Hiwatashi N, Sasaki D. A phase II trial of the novel serotonin type 3 receptor antagonist ramosetron in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome. Digestion 2008 77 : 225 235.
17. 3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals. Brain Res 1993 612 : 289 298.
18. Curtis GH, Patrick MK, Catto-Smith AG, Gall DG. Intestinal anaphylaxis in the rat. Effect of chronic allergen exposure. Gastroenterology 1990 98 : 1558 1566.
19. Cao Z, Wu X, Chen S et al. Anterior cingulate cortex modulates visceral pain as measured by visceromotor responses in viscerally hypersensitive rats. Gastroenterology 2008 134 : 535 543.
20. Gao J, Wu X, Owyang C, Li Y. Enhanced responses of the anterior cingulate cortex neurones to colonic distension in viscerally hypersensitive rats. J Physiol 2006 570 : 169 183.
21. Ness TJ, Gebhart GF. Colorectal distension as a noxious visceral stimulus: physiological and pharmacological characterization of pseudoaffective reflexes in the rat. Brain Res 1988 450 : 153 169.
22. Zhu JX, Zhu XY, Owyang C, Li Y. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J Physiol 2001 530 : 431 442. (Pubitemid 32162331)
23. -ΔΔCT Method. Methods 2001 25 : 402 408.
24. 3 receptors. Neuroscience 2006 143 : 273 287.
25. 3 receptors. Curr Pharm Des 2006 12 : 3615 3630.
26. Morales M, Wang SD. Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. J Neurosci 2002 22 : 6732 6741.
27. Williams RM, Berthoud HR, Stead RH. Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. Neuroimmunomodulation 1997 4 : 266 270.
28. Aerssens J, Hillsley K, Peeters PJ et al. Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice. Gastroenterology 2007 132 : 1375 1387.
29. Hillsley K, Kirkup AJ, Grundy D. Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum. J Physiol 1998 506 : 551 561.
30. 3B subunit is a major determinant of serotonin-receptor function. Nature 1999 397 : 359 363.
31. 3B receptor subunit. J Biol Chem 1999 274 : 30799 30810.
32. 3 receptor. J Biol Chem 2008 283 : 6826 6831.
33. 3A receptor subunit. J Neurosci 2004 24 : 5537 5548.