Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells

Journal of Biomedicine and Biotechnology

Volumn 2012, Issue , 2012, Pages

  Ryu, Chung Heon ^a   Yoon, Wan Soo ^b   Park, Kwang Ywel ^a   Kim, Seong Muk ^a   Lim, Jung Yeon ^a   Woo, Ji Sun ^a   Jeong, Chang Hyun ^a   Hou, Yun ^a   Jeun, Sin Soo ^a,c  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE; VALPROIC ACID; DACARBAZINE; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; MGMT PROTEIN, HUMAN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; FEMALE; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MONOTHERAPY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; BRAIN TUMOR; DOWN REGULATION; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; GLIOMA; TUMOR CELL LINE;

MUS;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; DACARBAZINE; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; MICE; TUMOR SUPPRESSOR PROTEINS; VALPROIC ACID; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84863665388     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2012/987495     Document Type: Article

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