Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

Asian Journal of Andrology

Volumn 14, Issue 4, 2012, Pages 584-590

  Geoffroy Siraudin, Cendrine ^a,b   Dieudonné Loundou, Anderson ^a   Romain, Fanny ^b   Achard, Vincent ^a   Courbière, Blandine ^a,b   Perrard, Marie Hélène ^c   Durand, Philippe ^c   Guichaoua, Marie Roberte ^a,b  

^a HÔPITAL DE LA CONCEPTION   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c CNRS   (France)

Author keywords

environment; male infertility; regional differences; semen quality; sperm parameters

Indexed keywords

ADULT; ARTICLE; AZOOSPERMIA; CELL STRUCTURE; CELL VIABILITY; CLINICAL ASSESSMENT; CONSULTATION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; EJACULATION; FRANCE; HUMAN; HUMAN CELL; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; OLIGOSPERMIA; PATIENT SELECTION; SEMEN ANALYSIS; SEMINAL PLASMA; SENSITIVITY AND SPECIFICITY; SEXUAL BEHAVIOR; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; UNIVERSITY HOSPITAL;

ADULT; FERTILITY; FRANCE; HUMANS; INFERTILITY, MALE; LINEAR MODELS; MALE; SEMEN; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA;

EID: 84863660032     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2011.173     Document Type: Article

References (55)

1. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609-13.
2. Auger J, Kunstmann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 1995; 332: 281-5.
3. Adamopoulos DA, Pappa A, Nicopoulou S, Andreou E, KaramertzansiMet al. Seminal volume and total sperm number trends in men attending subfertility clinics in the Greater Athens area during the period 1977-1993. Hum Reprod 1996; 11: 1936-41.
4. Van Waeleghem K, de Clercq N, Vermeulen L, Schoonjans F, Comhaire F. Deterioration of sperm quality in young healthy Belgian men. Hum Reprod 1996; 11: 325-9.
5. Lackner J, Schatzl G, Waldhor T, Resch K, Kratzik C et al. Constant decline in sperm concentration in infertile males in an urban population: Experience over 18 years. Fert Steril 2005; 84: 1657-61.
6. Spirada S, Fonseca S, Lee A, Harrild K, Giannaris D et al. Trends in semen parameters in the northeast of Scotland. J Androl 2007; 28: 313-9.
7. Shine R, Peek J, Birdsall M. Declining sperm quality in New Zealand over 20 years. NZ Med J 2008; 121: 50-6.
8. Mukhopadhyay D, Varghese A, Pal M, Banerjee S, Bhattacharyya A et al. Semen quality and age-specific changes: A study between two decades on 3729 male partners of couples with normal sperm count and attending an andrology laboratory for infertility-related problems in an Indian city. Fert Steril 2010; 93: 2247-54.
9. Bujan L, Mansat A, Pontonnier F, Mieusset R. Time series analysis of sperm concentration in fertile men in Toulouse between 1977 and 1992. BMJ 1996; 312: 471-2.
10. Berling S, Wölner-Hanssen P. No evidence of deteriorating semen quality among men in infertile relationships during the last decade: A study of males from Southern Sweden. Hum Reprod 1997; 12: 1002-5.
11. Rasmussen PE, Erb K, Westergaard LG, Laursen SB. No evidence for decreasing semen quality in four birth cohorts of 1055 Danish men born between 1950 and 1970. Fert Steril 1997; 68: 1059-64.
12. Emanuel E, Gobuloff E, Fisch H. MacLeod revisited: Sperm counts distributions in 374 fertile men from 1971 to 1994. Urology 1998; 51: 86-8.
13. Seo JT, Rha K, Park YS, Lee MS. Semen quality over a 10 year period in 22249 men in Korea. Int J Androl 2000; 3: 194-8.
14. Itoh N, Kayama F, Tatsuki J, Tsukamoto T. Have sperm counts deteriorated over the past 20 years in healthy young Japanese men? Results from the Sapporo area. J Androl 2001; 22: 40-4.
15. Costello MF, Sjoblom P, Haddad Y, Steigrad SJ, Bosch EG. No decline in semen quality among potential sperm donors in Sydney, Australia, between 1983 and 2001. J Assist Reprod Genet 2002; 19: 284-90.
16. Marimuthu P, Kapilashrami MC, Misro MM, Singh G. Evaluation of trend in semen analysis for 11 years in subjects attending a fertility clinic in India. Asian J Androl 2003; 5: 221-5.
17. te Velde E, Burdof A, Nieschlag E, Eijkemens R, Kremer JA et al. Is human fecundity declinig in Western countries? Human Reprod 2010; 25: 1348-53.
18. Jensen TK, Sobotka T, Hansen MA, Pedersen AT, Lutz W et al. Declining trends in conception rates in recent birth cohorts of native Danish women: A possible role of deteriorating male reproductive health. Int J Androl 2008; 31: 81-92.
19. Joensen UN, Skakkebaek N, Jorgensen N. Is there a problem with male reproduction? Nat Clin Endo Metab 2009; 5: 144-5.
20. Paulsen CA, Berman NG, Wang C. Data from men in greater Seattle area reveals no downward trend in semen quality: Further evidence that deterioration of semen quality is not geographically uniform. Fert Steril 1996; 65: 1015-20.
21. Lipshultz L. The debate continues'-the continuing debate over the possible decline in semen quality. Fert Steril 1996; 65: 909-11.
22. Jorgensen N, Andersen AG, Eustache F, Irvine S, Suominen J et al. Regional differences in semen quality in Europe. Hum Reprod 2001; 16: 1012-9.
23. Svechnikov K, Izzo G, Landreh L, Weisser J, Söder O. Endocrine disruptor and Leydig cell function. J Biomed Biotechnol 2010; 2010: Pii 684504.
24. Fisher JS. Environmental anti-androgens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004; 27; 305-15.
25. Aquila S, Sisci D, Gentile M, Middea E, Catalano S et al. Estrogen receptor ERa and ERb are both expressed in human ejaculated spermatozoa: Evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway. J Clin Endocrinol Metab 2004; 89: 1443-51.
26. Aquila S, Liddea E, Catalano S, Marsico S, Lanzino M et al. Human sperm express a functional androgen receptor: Effects on PI3K/AKT pathway. Hum Reprod 2007; 22: 2594-605.
27. Solakidi S, Psarra AMG, Nikolaropoulos S, Sekeris CE. Estrogen receptor a and b (ERa and ERb) and androgen receptor (AR) in the human sperm: Localization of ERb and AR in mitochondria of the midpiece. Hum Reprod 2005; 20: 3481-7.
28. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16: 231-45.
29. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge: CAMBRIDGE University Press; 1987. p1992.
30. World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th ed. Geneva: WORLD Health Organization; 2010.
31. David G, Bisson JP, Czyglik F, Jouannet P, Gernigon C. Anomalies morphologiques du spermatozoïde humain. Propositions pour un système de classification. J Gynecol Obstet Biol Reprod 1975; 4: 17-36.
32. Auger J, Eustache F. Standardisation de la classification morphologique des spermatozoïdes humains selon la mé thode de David modifiée. Andrologie 2000; 10: 358-73.
33. Comhaire FH, Vermeulen L, Schoonjans F. Reassessment of the accuracy of traditional sperm characteristics and adenosine triphosphate (ATP) in estimating the fertilizing potential of human semen in vivo. Int JAndrol 1987; 10: 653-62.
34. Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risks of male infertility. Hum Reprod 2001; 16: 1768-76.
35. Feki NC, Abid N, Rebai A, Sellami A, Ayed BB et al. Semen quality decline among men in infertile relationships: Experience over 12 years in the south of Tunisia. J Androl 2009; 30: 541-7.
36. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993; 341: 1392-5.
37. Irvine S, Cawood C, Richardson D, MacDonald E, Aitken J. Evidence of deteriorating semen quality in the United Kingdom: Birth cohort study in men in Scotland over 11 years. BMJ 1996; 312: 467-71.
38. Eertmans F, Dhooge W, Stuyvaert S, Comhaire F. Endocrine disruptors: Effects on male fertility and screening tools for their assessment. Tox in Vitro 2003; 17: 515-24.
39. Burns WR, Sabanegh E, Dada R, Rein B, Agarwal A. Is male infertility a forerunner to cancer? Int Braz J Urol 2010; 36: 527-36.
40. Hsu PC, Chen IY, Wu KY, Pan MH, Chen JR et al. Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers. Int Arch Occup Environ Health 2006; 79: 349-56.
41. Han X, Zhou N, Cui Z, Li L, CaiMet al. Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage: A population study in Chongqing, China. Environ Health Persp 2011; 119: 652-7
42. Lambard S, Galeraud-Denis I, Bouraïma H, Bourguiba S, Chocat A et al. Expression of aromatase in Human ejaculated spermatozoa: A putative marker of motility. Mol Hum Reprod 2003; 9: 117-24.
43. Aquila S, Sisci D, Gentile M, Middea E, Siciliano L et al. Human ejaculated spermatozoa contain active P450 Aromatase. J Clin Endocrinol Metab 2002; 87: 3385-90.
44. Franco R, Boscia F, Gigantino V, Marra L, Esposito F et al. GPR30 is over expressed in post-pubertal testicular germ cell tumors. Cancer Biol Ther 2011; 15: 609-13.
45. Jowa L, Howd R. Should atrazine and related chlorotriazines be considered carcinogenic for human health risk assessment. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2011; 29: 91-144.
46. Giwercman A, Lundberg-Giwercman Y. Environmental factors and testicular function. Best Pract Res Clin Endocrinol Metab 2011; 25: 391-402.
47. Uroz L, Rajmil O, Templado C. Meiotic chromosomes abnormalities in fertile men are they increasing? Fert Steril 2011; 95: 141-6.
48. Geoffoy-Siraudin C, Perrard MH, Chaspoul F, Lanteaume A, Gallice P et al. Validation of a rat seminiferous tubule culture model as a suitable system for studying toxicant impact on meiosis effect of hexavalent chromium. Tox Sci 2010; 116: 286-96.
49. Pacchierotti F, Adler ID, Eichenlaub-Ritter U, Mailhes JB. Gender effects on the incidence of aneuploidy in mammalian germ cells. Environ Res 2007; 104: 46-69.
50. Toppari J, Virtanen HE, main KM, Skakkebaek NE. Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): Environmental connection. Birth Defects Res A Clin Mol Teratol 2010; 88: 910-9.
51. Fish H, Goluboff ET. Geographic variations in sperm counts: A potential cause of bias in studies of semen quality. Fertil Steril 1996; 5: 1044-6.
52. Jorgensen N, Andersen AG, Eustache F, Irvine DS, Suominen J et al. Regional differences in semen quality in Europe. Hum Reprod 2001; 16: 1012-9.
53. Jouannet P, Ducot B, Feneux D, Spira A. Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics. Int J Androl 1988; 11: 379-94.
54. Bonde JP, Ernst E, Jensen TK, Hjolund NH, Kolstad H et al. Relation between semen quality and fertility. A population based study of 430 first-pregnancy planners. Lancet 1998; 352: 1172-7.
55. Skakkebaek NE. Normal references ranges for semen quality and their relations to fecundity. Asian J Androl 2010; 12: 95-8.