Il-1beta signals through the egf receptor and activates egr-1 through mmp-adam

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Sanchez Guerrero, Estella ^a   Chen, Elya ^a   Kockx, Maaike ^a   An, Si Wei ^a   Chong, Beng H ^a   Khachigian, Levon M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WOUND HEALING;

ADAM PROTEINS; ANIMALS; DIPEPTIDES; EARLY GROWTH RESPONSE PROTEIN 1; HUMANS; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASES; MYOCYTES, SMOOTH MUSCLE; QUINAZOLINES; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TYRPHOSTINS;

MURINAE;

EID: 84863654020     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039811     Document Type: Article

References (51)

1. Schwartz SM, (1997) Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest 99: 2814-2817.
2. Campbell GR, Campbell JH, (1985) Smooth muscle phenotypic changes in arterial wall homeostasis: implications for the pathogenesis of atherosclerosis. Exp Mol Pathol 42: 139-162.
3. Owens GK, Kumar MS, Wamhoff BR, (2004) Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801.
4. Gashler A, Sukhatme V, (1995) Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog Nucl Acid Res 50: 191-224.
5. Khachigian LM, (2006) Early growth response-1 in cardiovascular pathobiology. Circ Res 98: 186-191.
6. Khachigian LM, Anderson KA, Halnon NJ, Resnick N, Gimbrone MA Jr, et al. (1997) Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress response element in the PDGF A-chain promoter. Arterioscl Thromb Vasc Biol 17: 2280-2286.
7. Khachigian LM, Lindner V, Williams AJ, Collins T, (1996) Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 271: 1427-1431.
8. Yan S-F, Zou US, Gao Y, Zhai C, Mackman N, et al. (1998) Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci USA 95: 8298-8303.
9. de Mestre AM, Rao S, Hornby JR, Soe-Htwe T, Khachigian LM, et al. (2005) Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells. J Biol Chem 280: 35136-35147.
10. Wang B, Chen J, Santiago FS, Janes M, Kavurma MM, et al. (2010) Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin-1beta induction of early growth response 1 transcription. Arterioscler Thromb Vasc Biol 30: 536-545.
11. Howe CL, Mayoral S, Rodriguez M, (2006) Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1beta. Neurobiol Dis 23: 731-739.
12. Doran AC, Meller N, McNamara CA, (2008) Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol 28: 812-819.
13. Libby P, Warner SJ, Friedman GB, (1988) Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest 81: 487-498.
14. Raines EW, Dower SK, Ross R, (1989) Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science 243: 393-396.
15. Rectenwald JE, Moldawer LL, Huber TS, Seeger JM, Ozaki CK, (2000) Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation 102: 1697-1702.
16. Isoda K, Shiigai M, Ishigami N, Matsuki T, Horai R, et al. (2003) Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury. Circulation 108: 516-518.
17. McCaffrey TA, Fu C, Du C, Eskinar S, Kent KC, et al. (2000) High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest 105: 653-662.
18. Santiago FS, Lowe HC, Kavurma MM, Chesterman CN, Baker A, et al. (1999) New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth factor injury. Nature Med 5: 1264-1269.
19. Lowe HC, Chesterman CN, Khachigian LM, (2002) Catalytic antisense DNA molecules targeting Egr-1 inhibit neointima formation following permanent ligation of rat common carotid arteries. Thromb Haemost 87: 134-140.
20. Lowe HC, Fahmy RG, Kavurma MM, Baker A, Chesterman CN, et al. (2001) Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis. Circulation Research 89: 670-677.
21. Ohtani K, Egashira K, Usui M, Ishibashi M, Hiasa KI, et al. (2004) Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits. Gene Ther 11: 126-132.
22. Newby AC, (2006) Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates. Cardiovasc Res 69: 614-624.
23. Chang C, Werb Z, (2001) The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 11: S37-43.
24. Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, et al. (2005) G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem 280: 26592-26599.
25. Johnson TW, Wu YX, Herdeg C, Baumbach A, Newby AC, et al. (2005) Stent-based delivery of tissue inhibitor of metalloproteinase-3 adenovirus inhibits neointimal formation in porcine coronary arteries. Arterioscler Thromb Vasc Biol 25: 754-759.
26. Johnson JL, Dwivedi A, Somerville M, George SJ, Newby AC, (2011) Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice. Arterioscler Thromb Vasc Biol 31: e35-44.
27. Takaguri A, Kimura K, Hinoki A, Bourne AM, Autieri MV, et al. (2011) A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature. Hypertension 57: 841-845.
28. Berasain C, Perugorria MJ, Latasa MU, Castillo J, Goni S, et al. (2009) The epidermal growth factor receptor: a link between inflammation and liver cancer. Exp Biol Med (Maywood) 234: 713-725.
29. Chan HW, Smith NJ, Hannan RD, Thomas WG, (2006) Tackling the EGFR in pathological tissue remodelling. Pulm Pharmacol Ther 19: 74-78.
30. Citri A, Yarden Y, (2006) EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7: 505-516.
31. Sibilia M, Kroismaryr R, Lichtenberger B, Natarajan A, (2007) The epidermal growth factor receptor: from development to tumorigenesis. Differentiation 75: 770-787.
32. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, et al. (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402: 884-888.
33. Lemire JM, Covin CW, White S, Giachelli CM, Schwartz SM, (1994) Characterization of cloned aortic smooth muscle cells from young rats. Am J Pathol 144: 1068-1081.
34. Khachigian LM, Owensby DA, Chesterman CN, (1992) A tyrosinated peptide representing the alternatively spliced exon of the PDGF A-chain binds specifically to cultured cells and interferes with binding of several growth factors. J Biol Chem 267: 1660-1666.
35. Sanchez-Guerrero E, Midgley VC, Khachigian LM, (2008) Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation. Nucleic Acids Res 36: 1941-1951.
36. Day FL, Rafty LA, Chesterman CN, Khachigian LM, (1999) Angiotensin II (ATII)-inducible platelet-derived growth factor A-chain gene expression is p42/44 extracellular signal-regulated kinase-1/2 and Egr-1-dependent and mediated via the ATII type 1 but not type 2 receptor. Induction by ATII antagonized by nitric oxide. J Biol Chem 274: 23726-23733.
37. Fahmy RG, Dass CR, Sun LQ, Chesterman CN, Khachigian LM, (2003) Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nature Med 9: 1026-1032.
38. Poncet N, Guillaume J, Mouchiroud G, (2011) Epidermal growth factor receptor transactivation is implicated in IL-6-induced proliferation and ERK1/2 activation in non-transformed prostate epithelial cells. Cell Signal 23: 572-578.
39. Reddy AB, Ramana KV, Srivastava S, Bhatnagar A, Srivastava SK, (2009) Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology 150: 63-74.
40. Bhindi R, Fahmy RG, Lowe HC, Chesterman CN, Dass CR, et al. (2007) Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies. Am J Pathol 171: 1079-1088.
41. Bos M, Mendelsohn J, Kim YM, Albanell J, Fry DW, et al. (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res 3: 2099-2106.
42. Bowers G, Reardon D, Hewitt T, Dent P, Mikkelsen RB, et al. (2001) The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. Oncogene 20: 1388-1397.
43. Saito S, Frank GD, Motley ED, Dempsey PJ, Utsunomiya H, et al. (2002) Metalloprotease inhibitor blocks angiotensin II-induced migration through inhibition of epidermal growth factor receptor transactivation. Biochem Biophys Res Commun 294: 1023-1029.
44. White KJ, Maffei VJ, Newton-West M, Swerlick RA, (2011) Irritant activation of epithelial cells is mediated via protease-dependent EGFR activation. J Invest Dermatol 131: 435-442.
45. Fuentes LQ, Reyes CE, Sarmiento JM, Villanueva CI, Figueroa CD, et al. (2008) Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways. Cell Signal 20: 1642-1650.
46. Hall KC, Blobel CP, (2012) Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735. PloS ONE 7: e31600.
47. Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H, et al. (2008) Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Sci 99: 214-220.
48. Wan YS, Wang ZQ, Voorhees J, Fisher G, (2001) EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes. Cell Signal 13: 139-144.
49. Keates S, Keates AC, Nath S, Peek RM Jr, Kelly CP, (2005) Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut 54: 1363-1369.
50. Luo X, Cai H, Ni J, Bhindi R, Lowe HC, et al. (2009) c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size and improve cardiac function after ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol 29: 1836-1842.
51. Bhindi R, Fahmy RG, McMahon AC, Khachigian LM, Lowe HC, (2011) Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion. J Pathol In press.