Excess genistein suppresses the synthesis of extracellular matrix in female rat mandibular condylar cartilage

Acta Pharmacologica Sinica

Volumn 33, Issue 7, 2012, Pages 918-923

  Yu, Shi Bin ^a   Xing, Xiang Hui ^a   Dong, Guang Ying ^a   Weng, Xi Li ^a   Wang, Mei Qing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

estrogen; estrogen receptors; genistein; mandibular condylar cartilage; osteoarthritis

Indexed keywords

AGGRECAN; AROMATASE; COLLAGEN TYPE 3; CYCLINE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENISTEIN; SCLEROPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; IMMUNOHISTOCHEMISTRY; MANDIBLE CONDYLE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; THICKNESS; TREATMENT DURATION;

ANIMALS; CARTILAGE; CELL PROLIFERATION; CHONDROCYTES; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; EXTRACELLULAR MATRIX; FEMALE; GENISTEIN; MANDIBULAR CONDYLE; PHYTOESTROGENS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84863641245     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.49     Document Type: Article

References (30)

1. Claassen H, Briese V, Manapov F, Nebe B, Schünke M, Kurz B. The phytoestrogens daidzein and genistein enhance the insulin-stimulated sulfate uptake in articular chondrocytes. Cell Tissue Res 2008; 333: 71-9.
2. Bergink AP, van Meurs JB, Loughlin J, Arp PP, Fang Y, Hofman A, et al. Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women. Arthritis Rheum 2003; 48: 1913-22.
3. Spector TD, Campion GD. Generalised osteoarthritis: a hormonally mediated disease. Ann Rheum Dis 1989; 48: 523-7.
4. Ushiyama T, Ueyama H, Inoue K, Nishioka J, Ohkubo I, Hukuda S. Estrogen receptor gene polymorphism and generalized osteoarthritis. J Rheumatol 1998; 25: 134-7.
5. Felson DT, Nevitt MC. Estrogen and osteoarthritis: how do we explain conflicting study results? Prev Med 1999; 28: 445?8; discussion 449-50.
6. Nevitt MC, Cummings SR, Lane NE, Hochberg MC, Scott JC, Pressman AR, et al. Association of estrogen replacement therapy with the risk of osteoarthritis of the hip in elderly white women. Study of Osteoporotic Fractures Research Group. Arch Intern Med 1996; 156: 2073-80.
7. Spector TD, Nandra D, Hart DJ, Doyle DV. Is hormone replacement therapy protective for hand and knee osteoarthritis in women? The Chingford Study. Ann Rheum Dis 1997; 56: 432-4.
8. Azoulay C. Menopause in 2004: "hormone replacement therapy" is not what it used to be anymore. Rev Med Interne 2004; 25: 806-15.
9. Li W, Liu YH. Effects of phytoestrogen genistein on genioglossus function and oestrogen receptors expression in ovariectomized rats. Arch Oral Biol 2009; 54: 1029-34.
10. Clarkson TB, Anthony MS, Williams JK, Honore EK, Cline JM. The potential of soybean phytoestrogens for postmenopausal hormone replacement therapy. Proc Soc Exp Biol Med 1998; 217: 365-8.
11. Brzezinski A, Debi A. Phytoestrogens: the "natural" selective estrogen receptor modulators. Eur J Obstet Gynecol Rep Biol 1999; 85: 47-51.
12. Kapiotis S, Hermann M, Held I, Seelos C, Ehringer H, Gmeiner BM. Genistein, the dietary derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arterioscler Thromb Vasc Biol 1997; 17: 2868-74.
13. McClain RM, Wolz E, Davidovich A, Edwards J, Bausch J. Reproductive safety studies with genistein in rats. Food Chem Toxicol 2007; 45: 1319-32.
14. Arjmandi BH, Khalil DA, Lucas EA, Smith BJ, Sinichi N, Hodges SB, et al. Soy protein may alleviate osteoarthritis symptoms. Phytomedicine 2004; 1: 567-75.
15. Hooshmand S, Soung do Y, Lucas EA, Madihally SV, Levenson CW, Arjmandi BH. Genistein reduces the production of proinflammatory molecules in human chondrocytes. J Nutr Biochem 2007; 18: 609-14.
16. Okeson JP, editors. Management of temporomandibular disorders and occlusion, 5th Edition. St Lousis: Mosby Inc; 2003.
17. Yamashiro T, Takano-Yamamoto T. Differential responses of mandibular condyle and femur to oestrogen deficiency in young rats. Arch Oral Biol 1998; 43: 191-5.
18. Yasuoka T, Nakashima M, Okuda T, Tatematsu N. Effect of estrogen replacement on temporomandibular joint remodeling in ovariectomized rats. J Oral Maxillofac Surg 2000; 58: 189-96.
19. Talwar RM, Wong BS, Svoboda K, Harper RP. Effects of estrogen on chondrocyte proliferation and collagen synthesis in skeletally mature articular cartilage. J Oral Maxillofac Surg 2006; 64: 600-9.
20. Yamada K, Nozawa-Inoue K, Kawano Y, Kohno S, Amizuka N, Iwanaga T, et al. Expression of estrogen receptor alpha (ER alpha) in the rat temporomandibular joint. Anat Rec A Discov Mol Cell Evol Biol 2003; 274: 934-41.
21. Yu SB, Wang MQ, Li YQ, Lv X, Jiang Y, Dong GY, et al. The effects of age and sex on the expression of oestrogen and its receptors in rat mandibular condylar cartilages. Arch Oral Biol 2009; 54: 479-85
22. Li YQ, Xing XH, Wang H, Weng XL, Yu SB, Dong GY. Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone. Acta Pharmacol Sin 2012; 33: 66-74.
23. Michael MR, Wolz E, Davidovich A, Pfannkuch F, Edwards JA, Bausch J. Acute, subchronic and chronic safety studies with genistein in rats. Food Chem Toxicol 2006; 44: 56-80.
24. Yu SB, Wang MQ, Zhao W, Cao HT, Liu YL. The effects of age and sex on the expression of aromatase in the rat temporomandibular joint. J Orofac Pain 2006; 20: 156-65.
25. Seibel J, Molzberger AF, Hertrampf T, Laudenbach-Leschowski U, Diel P. Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis. Eur J Nutr 2009; 48: 213-20.
26. Ham KD, Oegema TR, Loeser RF, Carlson CS. Effects of long-term estrogen replacement therapy on articular cartilage IGFBP-2, IGFBP-3, collagen and proteoglycan levels in ovariectomized cynomolgus monkeys. Osteoarthritis Cartilage 2004; 12: 160-8.
27. Casanova M, Li Y, Gaido KW, Archibeque-Engle S, Janszen DB, Heck HA. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro. Toxicol Sci 1999; 51: 236-44.
28. Kostelac D, Rechkemmer G, Briviba K. Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element. J Agric Food Chem 2003; 51: 7632-5.
29. Atteritano M, Mazzaferro S, Frisina A, Cannata ML, Bitto A, D'Anna R, et al. Genistein effects on quantitative ultrasound parameters and bone mineral density in osteopenic postmenopausal women. Osteoporos Int 2009; 20: 1947-54.
30. Velders M, Solzbacher M, Schleipen B, Laudenbach U, Fritzemeier KH, Diel P. Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-beta mediated pathways. J Steroid Biochem Mol Biol 2010; 120: 53-9.