The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Fusco, Carmela ^a   Micale, Lucia ^a   Egorov, Mikhail ^b   Monti, Maria ^c   D'Addetta, Ester Valentina ^a   Augello, Bartolomeo ^a   Cozzolino, Flora ^c   Calcagnì, Alessia ^a   Fontana, Andrea ^a   Polishchuk, Roman S ^b   Didelot, Gerard ^d   Reymond, Alexandre ^d   Pucci, Piero ^c   Merla, Giuseppe ^a  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; HISTONE DEACETYLASE 6; PROTEASOME; PROTEIN P62; TRIPARTITE MOTIF PROTEIN 50; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AGGRESOME; ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL ACTIVITY; EMBRYO; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; FIBROBLAST; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; UBIQUITINATION;

ANIMALS; AUTOPHAGY; FEMALE; HISTONE DEACETYLASES; HUMANS; INCLUSION BODIES; LYSOSOMES; MALE; MICE; MICE, INBRED C3H; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN TRANSPORT; PROTEOLYSIS; RNA-BINDING PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATED PROTEINS;

EID: 84863609087     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040440     Document Type: Article

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