Generation and characterization of bioluminescent xenograft mouse models of MLL-related acute leukemias and in vivo evaluation of luciferase-targeting siRNA nanoparticles

International Journal of Oncology

Volumn 41, Issue 2, 2012, Pages 621-628

  Fazzina, Raffaella ^a   Lombardini, Lorenza ^a   Mezzanotte, Laura ^b   Roda, Aldo ^b   Hrelia, Patrizia ^b   Pession, Andrea ^a   Tonelli, Roberto ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Biotechnologic drug development; Drug delivery; In vivo bioluminescence imaging (BLI); Luciferase targeting siRNA; MLL related acute leukemia; Nanoparticle complex; Xenograft mouse model

Indexed keywords

FIREFLY LUCIFERASE; MIXED LINEAGE LEUKEMIA PROTEIN; NANOPARTICLE; SMALL INTERFERING RNA;

ACUTE BIPHENOTYPIC LEUKEMIA; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; BONE MARROW; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SPLEEN; STABLE TRANSFECTION; TISSUE SECTION;

ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LEUKEMIA, BIPHENOTYPIC, ACUTE; LIVER; LUCIFERASES, FIREFLY; LUMINESCENT MEASUREMENTS; MICE; MICE, INBRED NOD; MICE, SCID; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NANOPARTICLES; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEINS, FUSION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPLEEN; TRANSFECTION; WHOLE BODY IMAGING;

EID: 84863606050     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1504     Document Type: Article

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