Comparison of epitope specificity of anti-heat shock protein 60/65 IgG type antibodies in the sera of healthy subjects, patients with coronary heart disease and inflammatory bowel disease

Cell Stress and Chaperones

Volumn 17, Issue 2, 2012, Pages 215-227

  Füst, George ^a   Uray, Katalin ^b   Bene, László ^c   Hudecz, Ferenc ^b,d   Karádi, István ^a   Prohászka, Zoltán ^a,e  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^c Peterfy Sandor Hospital   (Hungary)

^d EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^e INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Coronary heart disease; Epitope analysis; Human HSP60; Inflammatory bowel disease; Mycobacterial HSP65

Indexed keywords

ALANYLALANYLGLYCYLALANYLASPARAGYLPROLYLLEUCYLGLYCYLLEUCYLLYSINE; ALANYLALANYLISOLEUCYLSERYLALANYLGLYCYLASPARTYLGLUTAMYLSERYLISOLEUCINE; ALANYLLEUCYLVALYLARGINYLGLUTAMYLGLYCYLLEUCYLARGINYLASPARAGYLVALINE; ARGINYLPHENYLALANYLASPARTYLLYSYLGLYCYLTYROSYLISOLEUCYLSERYLGLYCYLTYROSINE; EPITOPE; GLUTAMYLISOLEUCYLALANYLALANYLTHREONYLALANYLALANYLISOLEUCYLSERYLALANINE; GLUTAMYLLEUCYLASPARAGYLARGINYLVALYLALANYLALANYLGLYCYLALANYLASPARAGINE; GLUTAMYLSERYLASPARAGYLTHREONYLPHENYLALANYLGLYCYLLEUCYLGLUTAMYLLUECYLGLUTAMIC ACID; GLYCYLASPARTYLGLUTAMYLSERYLISOLEUCYLGLYCYLASPARTYLLEUCYLISOLEUCYLALANINE; GLYCYLLEUCYLGLUTAMYLLEUCYLGLUTAMYLLEUCYLTHREONYLGLUTAMYLGLYCYLMETHIONINE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 60 ANTIBODY; HEAT SHOCK PROTEIN 65 ANTIBODY; IMMUNOGLOBULIN G; LEUCYLTHREONYLGLUTAMYLMETHIONYLARGINYLPHENYLALANYLASPARTYLLYSYLGLYCINE; LYSYLTRYPTOPHYLGLYCYLALANYLPROLYLTHREONYLISOLEUCYLASPARAGYLTHREONYLASPARAGYLASPARTIC ACID; LYSYLVALYLTHREONYLLEUCYLGLYCYLPROLYLLYSYLGLYCYLARGINYLASPARAGINE; PHENYLALANYLVALYLTHREONYLASPARTYLPROLYLGLUTAMYLARGINYLGLUTAMYLGLUTAMYLALANINE; PROLYLGLYCYLPHENYLALANYLGLYCLASPARTYLARGINYLARGINYLLYSYLALANYLMETHIONINE; PROLYLLEUCYLGLYCYLLEUCYLLYSYLARGINYLGLYCYLISOLEUCYLGLUTAMYLLYSINE; PROLYLLYSYLGLYCYLARGINYLASPARAGYLVALYLVALYLLEUCYLGLUTAMYLLYSINE; SERYLSERYLLYSYLVALYLSERYLTHREONYLVALYLLYSYLASPARTYLLUECINE; SYNTHETIC PEPTIDE; THREONYLISOLEUCYLTHREONYLASPARAGYLASPARTYLGLYCYLVALYLSERYLISOLEUCYLALANINE; THREONYLVALYLLEUCYLALANYLGLUTAMYLALANYLLEUCYLVALYLARGINYLGLUTAMIC ACID; TYROSYLISOLEUCYLLEUCYLLEUCYLVALYLSERYLSERYLLYSYLVALYLSERINE; TYROSYLISOLEUCYLSERYLGLYCYLTYROSYLPHENYLALANYLVALYLTHREONYLASPARTYLPROLINE; UNCLASSIFIED DRUG; VALYLGLUTAMYLTHREONYLLYSYLGLUTAMYLGLUTAMYLISOLEUCYLALANYLALANYLTHREONINE; VALYLVALYLLEUCYLGLUTAMYLLYSYLLYSYLTRYPTOPHYLGLYCYLALANYLPROLINE;

ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; ISCHEMIC HEART DISEASE; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; BACTERIAL PROTEINS; CHAPERONIN 60; CORONARY DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; IMMUNOGLOBULIN G; INFLAMMATORY BOWEL DISEASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; REFERENCE STANDARDS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM BOVIS;

EID: 84863593944     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-011-0301-7     Document Type: Article

References (45)

1. Ayada K, Yokota K, Kobayashi K, Shoenfeld Y, Matsuura E, Oguma K (2009) Chronic infections and atherosclerosis. Clin Rev Allergy Immunol 37:44-48
2. Bene L, Fust G, Huszti Z, Hernadi Z, Fekete B, Meszaros M, Veres A, Kovacs A, Miklos K, Singh M, Romics L, Prohaszka Z (2002) Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease. Dig Dis Sci 47:1432-1437 (Pubitemid 34753917)
3. Birnie DH, Holme ER, McKay IC, Hood S, McColl KE, Hillis WS (1998) Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk. Eur Heart J 19:387-394 (Pubitemid 28120718)
4. Birnie DH, Vickers LE, Hillis WS, Norrie J, Cobbe SM (2005) Increased titres of anti-human heat shock protein 60 predict an adverse one year prognosis in patients with acute cardiac chest pain. Heart 91:1148-1153 (Pubitemid 41192383)
5. Burian K, Kis Z, Virok D, Endresz V, Prohaszka Z, Duba J, Berencsi K, Boda K, Horvath L, Romics L, Fust G, Gonczol E (2001) Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the develop-ment ofcoronary atherosclerosis. Circulation 103:1503-1508 (Pubitemid 32226256)
6. Campanella C, Marino Gammazza A, Mularoni L, Cappello F, Zummo G, Di Felice V (2009) A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response. Int J Immunogenet 36:73-78
7. Cohen IR, Young DB (1991) Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today 12:105-110
8. Foteinos G, Afzal AR, Mandal K, Jahangiri M, Xu Q (2005) Anti-heat shock protein 60 autoantibodies induce atherosclerosis in apolipoprotein E-deficient mice via endothelial damage. Circula-tion 112:1206-1213 (Pubitemid 41216128)
9. George J, Afek A, Gilburd B, Shoenfeld Y, Harats D (2001) Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice. J Am Coll Cardiol 38:900-905 (Pubitemid 32835770)
10. Geysen HM, Meloen RH, Barteling SJ (1984) Use ofpeptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc Natl Acad Sci U S A 81:3998-4002 (Pubitemid 14054511)
11. Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18:2714-2723 (Pubitemid 28059943)
12. Guex N, Diemand A, Peitsch MC (1999) Protein modelling for all. Trends Biochem Sci 24:364-367
13. Harats D, Yacov N, Gilburd B, Shoenfeld Y, George J (2002) Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J Am Coll Cardiol 40:1333-1338
14. Harkonen T, Puolakkainen M, Sarvas M, Airaksinen U, Hovi T, Roivainen M (2000) Picornavirus proteins share antigenic determinants with heat shock proteins 60/65. J Med Virol 62:383-391
15. Hoppichler F, Lechleitner M, Traweger C, Schett G, Dzien A, Sturm W, Xu Q (1996) Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction. Atherosclerosis 126:333-338 (Pubitemid 26336670)
16. Horvath L, Cervenak L, Oroszlan M, Prohaszka Z, Uray K, Hudecz F, Baranyi E, Madacsy L, Singh M, Romics L, Fust G, Panczel P (2002) Antibodies against different epitopes of heat-shock protein 60 in children with type 1 diabetes mellitus. Immunol Lett 80:155-162 (Pubitemid 34136002)
17. Huszti Z, Bene L, Kovacs A, Fekete B, Fust G, Romics L, Singh M, Prohaszka Z (2004) Low levels of antibodies against E. coli and mycobacterial 65 kDa heat shock proteins in patients with inflammatory bowel disease. Inflamm Res 53:551-555 (Pubitemid 40110121)
18. Kocsis J, Prohaszka Z, Biro A, Fust G, Banhegyi D (2003) Elevated levels of antibodies against 70 kDa heat shock proteins in the sera of patients with HIV infection. J Med Virol 71:480-482 (Pubitemid 37309916)
19. Krchnak V, Vagner J, Lebl M (1988) Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator Int J Pept Protein Res 32:415-416
20. Lachumanan R, Devi S, Cheong YM, Rodda SJ, Pang T (1993) Epitope mapping of the Sta58 major outer membrane protein of Rickettsia tsutsugamushi. Infect Immun 61:4527-4531 (Pubitemid 23298625)
21. Lindquist S, Craig EA (1988) The heat-shock proteins. Annu Rev Genet 22:631-677 (Pubitemid 19156675)
22. Lu X, Chen D, Endresz V, Xia M, Faludi I, Burian K, Szabo A, Csanadi A, Miczak A, Gonczol E, Kakkar V (2010) Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice. Atherosclerosis 212:472-480
23. Maeda H, Miyamoto M, Kokeguchi S, Kono T, Nishimura F, Takashiba S, Murayama Y (2000) Epitope mapping of heat shock protein 60 (GroEL) from Porphyromonas gingivalis. FEMS Immunol Med Microbiol 28:219-224 (Pubitemid 32939404)
24. Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL (2002) Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 106:1708-1715
25. Metzler B, Schett G, Kleindienst R, van der Zee R, Ottenhoff T, Hajeer A, Bernstein R, Xu Q, Wick G (1997) Epitope specificity of anti-heat shock protein 65/60 serum antibodies in atheroscle-rosis. Arterioscler Thromb Vasc Biol 17:536-541 (Pubitemid 27133144)
26. Peitsch MC (1996) ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem Soc Trans 24:274-279 (Pubitemid 26052435)
27. Perschinka H, Mayr M, Millonig G, Mayerl C, van der Zee R, Morrison SG, Morrison RP, Xu Q, Wick G (2003) Cross-reactive B-cell epitopes ofmicrobial and human heat shock protein 60/65 in atherosclerosis. Arterioscler Thromb Vasc Biol 23:1060-1065 (Pubitemid 36713561)
28. Perschinka H, Wellenzohn B, Parson W, van der Zee R, Willeit J, Kiechl S, Wick G (2007) Identification of atherosclerosis-associated conformational heat shock protein 60 epitopes by phage display and structural alignment. Atherosclerosis 194:79-87 (Pubitemid 47464310)
29. Pozsonyi E, Gyorgy B, Berki T, Banlaki Z, Buzas E, Rajczy K, Hosso A, Prohaszka Z, Szilagyi A, Cervenak L, Fust G (2009) HLA-association of serum levels of natural antibodies. Mol Immunol 46:1416-1423
30. Prohaszka Z, Duba J, Lakos G, Kiss E, Varga L, Janoskuti L, Csaszar A, Karadi I, Nagy K, Singh M, Romics L, Fust G (1999) Antibodies against human heat-shock protein (hsp) 60 and mycobacterial hsp65 differ in their antigen specificity and complement-activating ability Int Immunol 11:1363-1370 (Pubitemid 29425727)
31. Prohaszka Z, Duba J, Horvath L, Csaszar A, Karadi I, Szebeni A, Singh M, Fekete B, Romics L, Fust G (2001) Comparative study on antibodies to human and bacterial 60 kDa heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects. Eur J Clin Invest 31:285-292 (Pubitemid 32328528)
32. Puga Yung GL, Fidler M, Albani E, Spermon N, Teklenburg G, Newbury R, Schechter N, van den Broek T, Prakken B, Billetta R, Dohil R, Albani S (2009) Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn's disease. PLoS One 4:e7714
33. Schwede T, Diemand A, Guex N, Peitsch MC (2000) Protein structure computing in the genomic era. Res Microbiol 151:107-112 (Pubitemid 30366696)
34. Ulmansky R, Cohen CJ, Szafer F, Moallem E, Fridlender ZG, Kashi Y, Naparstek Y (2002) Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction ofIL-10 secretion. J Immunol 168:6463-6469 (Pubitemid 34620071)
35. Uray K, Hudecz F, Fust G, Prohaszka Z (2003) Comparative analysis of linear antibody epitopes on human and mycobacterial 60-kDa heat shock proteins using samples of healthy blood donors. Int Immunol 15:1229-1236 (Pubitemid 37220496)
36. van Eden W, Koets A, van Kooten P, Prakken B, van der Zee R (2003) Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity Vaccine 21:897-901 (Pubitemid 36126424)
37. Varbiro S, Biro A, Cervenak J, Cervenak L, Singh M, Banhidy F, Sebestyen A, Fust G, Prohaszka Z (2010) Human anti-60 kD heat shock protein autoantibodies are characterized by basic features ofnatural autoantibodies. Acta Physiol Hung 97:1-10
38. Veres A, Fust G, Smieja M, McQueen M, Horvath A, Yi Q, Biro A, Pogue J, Romics L, Karadi I, Singh M, Gnarpe J, Prohaszka Z, Yusuf S (2002) Relationship of anti-60 kDa heat shock protein and anti-cholesterol antibodies to cardiovascular events. Circula-tion 106:2775-2780 (Pubitemid 35396975)
39. Wick G, Xu Q (1999) Atherosclerosis-an autoimmune disease. Exp Gerontol 34:559-566
40. Wu T, Tanguay RM (2006) Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe? Cell Stress Chaperones 11:1-12 (Pubitemid 43363820)
41. Wysocki J, Karawajczyk B, Gorski J, Korzeniowski A, Mackiewicz Z, Kupryszewski G, Glosnicka R (2002) Human heat shock protein 60 (409-424) fragment is recognized by serum antibodies of patients with acute coronary syndromes. Cardiovasc Pathol 11:238-243 (Pubitemid 34828276)
42. Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl S, Stulnig T, Luef G, Wick G (1993) Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet 341:255-259 (Pubitemid 23038021)
43. Yamaguchi H, Osaki T, Kai M, Taguchi H, Kamiya S (2000) Immune response against a cross-reactive epitope on the heat shock protein 60 homologue of Helicobacter pylori. Infect Immun 68:3448-3454 (Pubitemid 30340443)
44. Yi Y Zhong G, Brunham RC (1993) Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60. Infect Immun 61:1117-1120 (Pubitemid 23059676)
45. Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, Pockley AG, Hu FB, Wu T (2008) Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese. Circulation 118:2687-2693