Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice

Atherosclerosis

Volumn 212, Issue 2, 2010, Pages 472-480

  Lu, Xinjie ^a   Chen, Daxin ^a   Endresz, Valeria ^b   Xia, Min ^a   Faludi, Ildiko ^b   Burian, Katalin ^b   Szabo, Andrea ^c   Csanadi, Agnes ^b   Miczak, Andras ^b   Gonczol, Eva ^d   Kakkar, Vijay ^e  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

^d NATIONAL CENTER FOR EPIDEMIOLOGY   (Hungary)

^e THROMBOSIS RESEARCH INSTITUTE   (India)

Author keywords

ApoB 100; HSP60 and atherosclerosis; LDLR; OxLDL

Indexed keywords

APOLIPOPROTEIN B; GAMMA INTERFERON; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

ANIMALS; APOLIPOPROTEIN B-100; APOLIPOPROTEINS B; ATHEROSCLEROSIS; AUTOANTIBODIES; CHAPERONIN 60; EPITOPES; HUMANS; IMMUNE SYSTEM; IMMUNITY, HUMORAL; IMMUNOHISTOCHEMISTRY; LIPOPROTEINS, LDL; MICE; MICE, INBRED C57BL; PEPTIDES; RECEPTORS, LDL;

EID: 77957698700     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.06.007     Document Type: Article

References (26)

1. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005, 352:1685-1695.
2. Ait-Oufella H., Salomon B.L., Potteaux S., Robertson A.K., Gourdy P., Zoll J., Merval R., Esposito B., Cohen J.L., Fisson S., Flavell R.A., Hansson G.K., Klatzmann D., Tedgui A., Mallat Z. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 2006, 12:178-180.
3. Schiopu A., Bengtsson J., Söderberg I., Janciauskiene S., Lindgren S., Ares M.P., Shah P.K., Carlsson R., Nilsson J., Fredrikson G.N. Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis. Circulation 2004, 110:2047-2052.
4. Binder C.J., Hörkkö S., Dewan A., Chang M.K., Kieu E.P., Goodyear C.S., Shaw P.X., Palinski W., Witztum J.L., Silverman G.J. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 2003, 9:736-743.
5. Nilsson J., Hansson G.K., Shah P.K. Immunomodulation of atherosclerosis: implications for vaccine development. Arerioscler Thromb Vasc Biol 2005, 25:18-28.
6. Schiopu A., Frendéus B., Jansson B., Söderberg I., Ljungcrantz I., Araya Z., Shah P.K., Carlsson R., Nilsson J., Fredrikson G.N. Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) mice. J Am Coll Cardiol 2007, 50:2313-2318.
7. Fredrikson G.N., Söderberg I., Lindholm M., Dimayuga P., Chyu K.Y., Shah P.K., Nilsson J. Inhibition of atherosclerosis in ApoE-null mice by immunization with ApoB-100 peptide sequences. Arterioscler Thromb Vasc Biol 2003, 23:879-884.
8. Foteinos G., Afzal A.R., Mandal K., Jahangiri M., Xu Q. Anti-heat shock protein 60 autoantibodies induce atherosclerosis in apolipoprotein E-deficient mice via endothelial damage. Circulation 2005, 112:1206-1213.
9. Benagiano M., D'Elios M.M., Amedei A., Azzurri A., van der Zee R., Ciervo A., Rombolà G., Romagnani S., Cassone A., Del Prete G. Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques. J Immunol 2005, 174:6017-6509.
10. Zugel U., Kaufmann S.H. Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev 1999, 12:19-39.
11. Ghayour-Mobarhan M., Lamb D.J., Tavallaie S., Ferns G.A. Relationship between plasma cholesterol, von Willebrand factor concentrations, extent of atherosclerosis and antibody titres to heat shock proteins-60, -65 and -70 in cholesterol-fed rabbits. Int J Exp Pathol 2007, 8:249-255.
12. van Puijvelde G.H., van Es T., van Wanrooij E.J., Habets K.L., de Vos P., van der Zee R., van Eden W., van Berkel T.J., Kuiper J. Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis. Arterioscler Thromb Vasc Biol 2007, 27:2677-2683.
13. Buono C., Come C.E., Stavrakis G., Maguire G.F., Connelly P.W., Lichtman A.H. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 2003, 23:454-460.
14. Branen L., Hovgaard L., Nitulescu M., Bengtsson E., Nilsson J., Jovinge S. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2004, 24:2137-2142.
15. Potteaux S., Esposito B., van O.O., Brun V., Ardouin P., Groux H., Tedgui A., Mallat Z. Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 2004, 24:1474-1478.
16. Frutkin A.D., Otsuka G., Stempien-Otero A., Sesti C., Du L., Jaffe M., Dichek H.L., Pennington C.J., Edwards D.R., Nieves-Cintrón M., Minter D., Preusch M., Hu J.H., Marie J.C., Dichek D.A. TGF-{beta}1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 2009, 29:1251-1257.
17. Savellano M.D., Pogue B.W., Hoopes P.J., Vitetta E.S., Paulsen K.D. Multiepitope HER2 targeting enhances photoimmunotherapy of HER2-overexpressing cancer cells with pyropheophorbide - a immunoconjugates. Cancer Res 2005, 65:6371-6379.
18. Kilpatrick K.E., Wring S.A., Walker D.H., Macklin M.D., Payne J.A., Su J.L., Champion B.R., Caterson B., McIntyre G.D. Rapid development of affinity matured monoclonal antibodies using RIMMS. Hybridoma 1997, 16:381-389.
19. Mor A., Planer D., Luboshits G., Afek A., Metzger S., Chajek-Shaul T., Keren G., George J. Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis. Arterioscler Thromb Vasc Biol 2007, 27:893-900.
20. Zygmunt B.M., Rharbaoui F., Groebe L., Guzman C.A. Intranasal immunization promotes Th17 immune responses. J Immunol 2009, 183:6933-6938.
21. Schapira K., Burkly L.C., Zheng T.S., Wu P., Groeneweg M., Rousch M., Kockx M.M., Daemen M.J., Heeneman S. Fn14-Fc Fusion Protein Regulates Atherosclerosis in ApoE-/- mice and inhibits macrophage lipid uptake in vitro. Arterioscler Thromb Vasc Biol 2009, 29:2021-2027.
22. Fredrikson G.N., Schiopu A., Berglund G., Alm R., Shah P.K., Nilsson J. Autoantibody against the amino acid sequence 661-680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular events. Atherosclerosis 2007, 194:e188-e192.
23. Bynum J., Andrews J.L., Ellis B., Kull F.C., Austin E.A., Kilpatrick K.E. Development of class-switched, affinity-matured monoclonal antibodies following a 7-day immunization schedule. Hybridoma 1999, 18:407-411.
24. Cruz L.J., Cabrales A., Iglesias E., Aguilar J.C., González L.J., Reyes O. Enhanced immunogenicity and cross-reactivity of HIV-1 V3-peptide and multiple antigen peptides conjugated to distinct carrier proteins. Int Immunopharmacol 2009, 9:1452-1459.
25. Millonig G., Schwentner C., Mueller P., Mayerl C., Wick G. The vascular-associated lymphoid tissue: a new site of local immunity. Curr Opin Lipidol 2001, 12:547-553.
26. Li W., Carper K., Zheng X.X., Kuhr C.S., Reyes J.D., Liang Y., Perkins D.L., Thomson A.W., Perkins J.D. The role of Foxp3+ regulatory T cells in liver transplant tolerance. Transplant Proc 2006, 38:3205-3206.