Clinical and molecular detection of inherited colorectal cancers in northeast Italy: A first prospective study of incidence of Lynch syndrome and MUTYH-related colorectal cancer in Italy

Tumor Biology

Volumn 33, Issue 3, 2012, Pages 857-864

  Urso, E ^a,b   Agostini, M ^a,b,c,d   Pucciarelli, S ^a,b   Rugge, M ^a   Bertorelle, R ^e   Maretto, I ^a,b   Bedin, C ^a,b,d   D'Angelo, E ^a,d   Mescoli, C ^d   Zorzi, M ^e   Viel, A ^f   Bruttocao, G ^a   Ferraro, B ^g   Erroi, F ^a   Contin, P ^a,b,h   De Salvo, G L ^e   Nitti, D ^a,b  

^a UNIVERSITY OF PADOVA   (Italy)

^b VI piano   (Italy)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^d Pediatric Research Institute   (Italy)

^e VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^f CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^g S ANTONIO HOSPITAL   (Italy)

^h UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Genetics screening; Incidence of familial CRCs; Lynch syndrome

Indexed keywords

MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; B RAF KINASE; DNA BINDING PROTEIN; DNA GLYCOSYLASE MUTY; DNA GLYCOSYLTRANSFERASE; G T MISMATCH BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; AGED; ARTICLE; BRAF GENE; CANCER INCIDENCE; CLINICAL FEATURE; COLON POLYPOSIS; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; FAMILY HISTORY; FEMALE; GENE; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC SCREENING; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; INHERITANCE; ITALY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MLH1 GENE; MLH2 GENE; MOLECULAR GENETICS; MUTYH GENE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; RISK ASSESSMENT; STRUCTURED INTERVIEW; CAUCASIAN; GENETICS; INCIDENCE; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOMATOUS POLYPOSIS COLI; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA GLYCOSYLASES; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENES, APC; GERM-LINE MUTATION; HUMANS; INCIDENCE; ITALY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS B-RAF; RETROSPECTIVE STUDIES;

EID: 84863589779     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-011-0312-0     Document Type: Article

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