High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy

Endocrine-Related Cancer

Volumn 12, Issue 4, 2005, Pages 867-874

  Pierantoni, Giovanna Maria ^a   Finelli, Palma ^b,c   Valtorta, Emanuele ^b   Giardino, Daniela ^b   Rodeschini, Ornella ^b,c   Esposito, Francesco ^a   Losa, Marco ^d   Fusco, Alfredo ^a,e,f   Larizza, Lidia ^b,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^f Dipartimento di Medicina Clinica e Chirurgia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HIGH MOBILITY GROUP A2 PROTEIN;

ARTICLE; CHROMOSOMAL INSTABILITY; CHROMOSOME 12; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DIPLOIDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS ADENOMA; NON FUNCTIONING PITUITARY ADENOMA; PROLACTINOMA; PROTEIN EXPRESSION; TRISOMY; UPREGULATION;

ADENOMA; ANEUPLOIDY; CHROMOSOMES, HUMAN, PAIR 12; GENE AMPLIFICATION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; HMGA2 PROTEIN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; PITUITARY NEOPLASMS; TRANS-ACTIVATION (GENETICS);

EID: 29144439963     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.1.01049     Document Type: Article

References (27)

1. Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K & Melmed S 2005 Early multipotential pituitary focal hyperplasia in {alpha}gsu-driven pituitary tumor transforming gene (PTTG) transgenic mice. Molecular Endocrinology 19 1383-1391.
2. Abe N, Watanabe T, Suzuki Y, Matsumoto N, Masaki T, Mori T, Sugiyama M, Chiappetta G, Fusco A & Atomi Y 2003 An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue. British Journal of Cancer 89 2104-2109.
3. Archidiacono N, Antonacci R, Marzella R, Finelli P, Lonoce A & Rocchi M 1995 Comparative mapping of human alphoid sequences in great apes using fluorescence in situ hybridization. Genomics 25 477-484.
4. Ashar HR, Fejzo MS, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC & Chada K 1995 Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82 57-65.
5. Baldini A, Rocchi M, Archidiacono N, Miller OJ & Miller DA 1990 A human alpha satellite DNA subset specific for chromosome 12. American Journal of Human Genetics 46 784-788.
6. Battista S, Fidanza V, Fedele M, Klein-Szanto AJ, Outwater E, Brunner H, Santoro M, Croce CM & Fusco A 1999 The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Research 59 4793-4797.
7. Berlingieri MT, Manfioletti G, Santoro M, Bandiera A, Visconti R, Giancotti V & Fusco A 1995 Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells. Molecular and Cellular Biology 15 1545-1553.
8. Bettio D, Rizzi N, Giardino D, Persani L, Pecori-Giraldi F, Losa M & La Rizza L 1997 Cytogenetic study of pituitary adenomas. Cancer Genetics and Cytogenetics 98 131-136.
9. Fashena ST, Reeves R & Ruddle NH 1992 A poly(dA-dT) upstream activating sequence binds high-mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-b) gene regulation. Molecular and Cellular Biology 12 894-903.
10. Fedele M, Berlingieri MT, Scala S, Chiaratti L, Viglietto G, Rippel V, Bullerdiek J, Santoro M & Fusco A 1998 Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibrablasts. Oncogene 17 413-418.
11. Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E et al. 2002 Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene 21 3190-3198.
12. Finelli P, Giardino D, Rizzi N, Buiatiotis S, Virduci T, Franzin A, Losa M & Larizza L 2000 Non random trisomies of chromosomes 5, 8 and 12 in the prolactinoma subtype of pituitary adenomas: conventional cytogenetics and interphase FISH study. International Journal of Cancer 86 344-350.
13. Finelli P, Pierantoni GM, Giardino D, Losa M, Rodeschini O, Fedele M, Valtorta E, Mortini P, Croce CM, Larizza L & Fusco A 2002 The high mobility group A2 gene is amplified and overexpressed in human prolactinomas. Cancer Research 62 2398-2405.
14. Giancotti V, Berlingieri MT, DiFiore PP, Fusco A, Vecchio G & Crane-Robinson C 1985 Changes in nuclear proteins on transformation of rat epithelial thyroid cells by a murine sarcoma retrovirus. Cancer Research 45 6051-6057.
15. Giancotti V, Pani B, D'Andrea P, Berlingieri MT, Di Fiore PP, Fusco A, Vecchio G, Philp R, Crane-Robinson C, Nicolas RH et al. 1987 Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes. EMBO Journal 6 1981-1987.
16. Grosschedl R, Giese K & Pagel J 1994 HMG domain proteins: architectural elements in the assembly of nucleoprotein structure. Trends in Genetics 10 94-100.
17. Kost-Alimova M, Fedorova L, Yang Y, Klein G & Imreh S 2004 Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural instability in tumor cell chromosomes through asynchronous replication and breakage within late-replicating regions. Genes Chromosomes & Cancer 40 316-324.
18. Kovacs K & Horvath E 1986 Tumors of the Pituitary Gland. Atlas of Tumor Pathology, Fascicle 21, series II. Washington DC: AFPI.
19. Levy A & Lightman S 2003 Molecular defects in the pathogenesis of pituitary tumours. Frontiers in Neuroendocrinology 24 94-127.
20. Lichter P & Cremer T 1992 Chromosome analysis by non-isotopic in situ hybridization. In: Human Cytogen. A practical approach, pp 157-192. Eds Rooney DE and Czipolkowski BH. Oxford: Oxford University press.
21. Lichter P, Tang Ghang CJ, Call K, Hermanson G, Evans GA, Housman D & Ward DC 1990 High resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 247 64-69.
22. Mitelman F 1995 ISCN. An International System for Human Cytogenetic Nomenclature. Ed F Mitelmann. Basel: Karger S.
23. Monson JP 2000 The epidemiology of endocrine tumours. Endocrine-related Cancer 7 29-36.
24. Pierantoni GM, Santulli B, Caliendo I, Pentimalli F, Chiappetta G, Zanesi N, Santoro M, Bulrich F & Fusco A 2003 HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. International Journal of Oncology 23 363-367.
25. Schoenmakers EF, Wanschura S, Mois R, Bullerdiek J, Van den Berghe H & Van de Ven WJ 1995 Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nature Genetics 10 436-444.
26. Theodoropoulou M, Arzberger T, Gruebler Y, Jaffrain-Rea ML, Schlegel J, Schaaf L, Petrangeli E, Losa M, Stalla GK & Pagotto U 2004 Differential expression of menin in sporadic pituitary adenomas. Endocrine-related Cancer 11 333-344.
27. Zhou X, Benson KF, Ashar HR & Chada K 1995 Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376 771-774.