A meta-analysis of the effectiveness of the opioid receptor antagonist alvimopan in reducing hospital length of stay and time to GI recovery in patients enrolled in a standardized accelerated recovery program after abdominal surgery

Diseases of the Colon and Rectum

Volumn 55, Issue 5, 2012, Pages 611-620

  Vaughan Shaw, P G ^a,b   Fecher, I C ^a,b   Harris, S ^a,b   Knight, J S ^a,b  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Alvimopan; Bowel resection; Length of stay; Meta analysis; Postoperative ileus

Indexed keywords

ALVIMOPAN; PLACEBO; MU OPIATE RECEPTOR; PIPERIDINE DERIVATIVE;

ABDOMINAL SURGERY; ARTICLE; DATA BASE; GASTROINTESTINAL SURGERY; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; INCIDENCE; LAPAROSCOPIC SURGERY; LENGTH OF STAY; META ANALYSIS; OUTCOME ASSESSMENT; POSTOPERATIVE ILEUS; CONVALESCENCE; DRUG ANTAGONISM; DRUG EFFECT; GASTROINTESTINAL TRACT; HEALTH CARE QUALITY; METHODOLOGY; PHYSIOLOGY; POSTOPERATIVE CARE; REVIEW; TREATMENT OUTCOME;

DIGESTIVE SYSTEM SURGICAL PROCEDURES; GASTROINTESTINAL TRACT; HUMANS; LENGTH OF STAY; PIPERIDINES; POSTOPERATIVE CARE; PROGRAM EVALUATION; RECEPTORS, OPIOID, MU; RECOVERY OF FUNCTION; TREATMENT OUTCOME;

EID: 84863583452     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0b013e318249fc78     Document Type: Article

References (44)

1. Wilmore DW, Kehlet H. Management of patients in fast track surgery. BMJ. 2001;322:473-476. (Pubitemid 32238809)
2. Fearon KC, Ljungqvist O, Von Meyenfeldt M, et al. Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr. 2005;24:466-477. (Pubitemid 40668435)
3. Basse L, Jakobsen DH, Bardram L, et al. Functional recovery after open versus laparoscopic colonic resection: a randomized, blinded study. Ann Surg. 2005;241:416-423. (Pubitemid 40299717)
4. King PM, Blazeby JM, Ewings P, et al. The influence of an enhanced recovery programme on clinical outcomes, costs and quality of life after surgery for colorectal cancer. Colorectal Dis. 2006;8:506-513. (Pubitemid 43834456)
5. Resnick J, Greenwald DA, Brandt LJ. Delayed gastric emptying and postoperative ileus after nongastric abdominal surgery: part II. Am J Gastroenterol. 1997;92:934-940. (Pubitemid 27237580)
6. Augestad KM, Delaney CP. Postoperative ileus: impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways. World J Gastroenterol. 2010;16:2067-2074.
7. Behm B, Stollman N. Postoperative ileus: etiologies and interventions. Clin Gastroenterol Hepatol. 2003;1:71-80. (Pubitemid 37248077)
8. Moss G, Regal ME, Lichtig L. Reducing postoperative pain, narcotics, and length of hospitalization. Surgery. 1986;99:206-210. (Pubitemid 16144921)
9. Delaney CP, Marcello PW, Sonoda T, Wise P, Bauer J, Techner L. Gastrointestinal recovery after laparoscopic colectomy: results of a prospective, observational, multicenter study. Surg Endosc. 2009;24:653-661.
10. Schwenk W, Haase O, Neudecker J, Muller JM. Short term benefits for laparoscopic colorectal resection. Cochrane Database Syst Rev. 2005:CD003145.
11. Murphy DB, Sutton JA, Prescott LF, Murphy MB. Opioid-induced delay in gastric emptying: a peripheral mechanism in humans. Anesthesiology. 1997;87:765-770. (Pubitemid 27456227)
12. Ingram DM, Sheiner HJ. Postoperative gastric emptying. Br J Surg. 1981;68:572-576. (Pubitemid 12219167)
13. Templeton R, Adler H. The influence of morphine on transportation in the colon of the dog. Am J Physiol. 1940;131:428-431.
14. Viscusi ER, Goldstein S, Witkowski T, et al. Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study. Surg Endosc. 2006;20:64-70. (Pubitemid 43097035)
15. Worster B, Holmes S. A phenomenological study of the postoperative experiences of patients undergoing surgery for colorectal cancer. Eur J Oncol Nurs. 2009;13:315-322.
16. Zeinali F, Stulberg JJ, Delaney CP. Pharmacological management of postoperative ileus. Can J Surg. 2009;52:153-157.
17. Taguchi A, Sharma N, Saleem RM, et al. Selective postoperative inhibition of gastrointestinal opioid receptors. N Engl J Med. 2001;345:935-940.
18. Delaney CP, Weese JL, Hyman NH, et al. Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis Colon Rectum 2005;48:1114-1129. (Pubitemid 40897853)
19. Ludwig K, Enker WE, Delaney CP, et al. Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway. Arch Surg. 2008;143:1098-1105.
20. Wolff BG, Michelassi F, Gerkin TM, et al. Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus. Ann Surg. 2004;240:728-735. (Pubitemid 39281295)
21. Buchler MW, Seiler CM, Monson JR, et al. Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study. Aliment Pharmacol Ther. 2008;28:312-325.
22. Tan EK, Cornish J, Darzi AW, Tekkis PP. Meta-analysis: alvimopan vs. placebo in the treatment of post-operative ileus. Aliment Pharmacol Ther. 2007;25:47-57. (Pubitemid 44902863)
23. Traut U, Brugger L, Kunz R, et al. Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults. Cochrane Database Syst Rev. 2008:CD004930.
24. Holte K, Kehlet H. Postoperative ileus: a preventable event. Br J Surg. 2000;87:1480-1493.
25. Zargar-Shoshtari K, Paddison JS, Booth RJ, Hill AG. A prospective study on the influence of a fast-track program on postoperative fatigue and functional recovery after major colonic surgery. J Surg Res. 2009;154:330-335.
26. Viscusi ER, Gan TJ, Leslie JB, et al. Peripherally acting mu-opioid receptor antagonists and postoperative ileus: mechanisms of action and clinical applicability. Anesth Analg. 2009;108:1811-1822.
27. Schulz KF, Altman DG, Moher D. CONSORT2010 statement: updated guidelines for reporting parallel group randomised trials. Int J Surg. 2011;9:672-677.
28. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62:1006-1012.
29. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17:2815-2834. (Pubitemid 28562978)
30. Wolff BG, Weese JL, Ludwig KA, et al. Postoperative ileus-related morbidity profile in patients treated with alvimopan after bowel resection. J Am Coll Surg. 2007;204:609-616. (Pubitemid 46428581)
31. Delaney C, Wolff B, Viscusi E, et al. Post-operative morbidity associated with laparotomy: results from a pooled analysis of three randomized controlled trials of alvimopan in the management of POI. Dis Colon Rectum. 2005;48:619.
32. Herzog TJ, Coleman RL, Guerrieri JP Jr, et al. A double-blind, randomized, placebo-controlled phase III study of the safety of alvimopan in patients who undergo simple total abdominal hysterectomy. Am J Obstet Gynecol. 2006;195:445-453. (Pubitemid 44142373)
33. Paulson DM, Kennedy DT, Donovick RA, et al. Alvimopan: an oral, peripherally acting, mu-opioid receptor antagonist for the treatment of opioid-induced bowel dysfunction-a 21-day treatment-randomized clinical trial. J Pain. 2005;6:184-192. (Pubitemid 40365022)
34. Harbour R, Miller J. A new system for grading recommendations in evidence based guidelines. BMJ. 2001;323:334-336. (Pubitemid 32744465)
35. Becker G, Blum HE. Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus. Lancet. 2009;373:1198-1206.
36. Ludwig K, Viscusi ER, Wolff BG, Delaney CP, Senagore A, Techner L. Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis. World J Surg. 2010;34:2185-2190.
37. Iyer S, Saunders WB, Stemkowski S. Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm. 2009;15:485-494.
38. HESonline. Hospital Episode Statistics. Main procedures and interventions: 4 character. 2010. Available at: www.hesonline.nhs.uk. Accessed March 20, 2011.
39. Bell TJ, Poston SA, Kraft MD, Senagore AJ, Delaney CP, Techner L. Economic analysis of alvimopan in North American Phase III efficacy trials. Am J Health Syst Pharm. 2009;66:1362-1368.
40. Poston S, Broder MS, Gibbons MM, et al. Impact of alvimopan (Entereg) on hospital costs after bowel resection: results from a large inpatient database. P T. 2011;36:209-220.
41. Kuhry E, Schwenk WF, Gaupset R, Romild U, Bonjer HJ. Long-term results of laparoscopic colorectal cancer resection. Cochrane Database Syst Rev. 2008:CD003432.
42. Absher RK, Gerkin TM, Banares LW. Alvimopan use in laparoscopic and open bowel resections: clinical results in a large community hospital system. Ann Pharmacother. 2010;44:1701-1708.
43. Obokhare ID, Champagne B, Stein SL, Krpata D, Delaney CP. The effect of alvimopan on recovery after laparoscopic segmental colectomy. Dis Colon Rectum. 2011;54:743-746.
44. Barletta JF, Asgeirsson T, El-Badawi KI, Senagore AJ. Introduction of alvimopan into an enhanced recovery protocol for colectomy offers benefit in open but not laparoscopic colectomy. J Laparoendosc Adv Surg Tech A. 2011;21:887-891.