Development and validation of a bedside risk score for MRSA among patients hospitalized with complicated skin and skin structure infections

BMC Infectious Diseases

Volumn 12, Issue , 2012, Pages

  Zilberberg, Marya D ^a,b   Chaudhari, Paresh ^c   Nathanson, Brian H ^d   Campbell, Rebecca S ^e   Emons, Matthew F ^e   Fiske, Suzanne ^e   Hays, Harlen D ^e   Shorr, Andrew F ^f  

^a EviMed Research Group LLC   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

^d OptiStatim LLC   (United States)

^e CERNER CORPORATION   (United States)

^f WASHINGTON HOSPITAL CENTER   (United States)

Author keywords

Clinical decision; Hospitalization; MRSA; Prediction rule; Skin infection

Indexed keywords

ADULT; AFRICAN AMERICAN; AGE; AGED; ARTICLE; BEDSIDE RISK SCORE; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE CLASSIFICATION; FEMALE; HEART ARRHYTHMIA; HOSPITAL INFECTION; HUMAN; INFECTION RISK; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; POINT OF CARE TESTING; PREDICTIVE VALUE; RACE DIFFERENCE; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCAL SKIN INFECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CLINICAL MEDICINE; COHORT STUDIES; DECISION SUPPORT TECHNIQUES; FEMALE; HOSPITALIZATION; HUMANS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCAL SKIN INFECTIONS; UNITED STATES; YOUNG ADULT;

EID: 84863568967     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-12-154     Document Type: Article

References (22)

1. Klein E, Smith DL, Laxminarayan R. Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005. Emerg Infect Dis 2007, 13(12):1840-1846. 10.3201/eid1312.070629, 2876761, 18258033.
2. Kallen AJ, Mu Y, Bulens S, Reingold A, Petit S, Gershman K, et al. Health care-associated invasive MRSA infections, 2005-2008. JAMA 2010, 304(6):641-648. 10.1001/jama.2010.1115, 20699455.
3. Dellit TH, Owens RC, McGowan JE, Gerding DN, Weinstein RA, Burke JP, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 2007, 44(2):159-177. 10.1086/510393, 17173212.
4. Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, et al. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis 2008, 46(2):155-164. 10.1086/524891, 18171244.
5. Micek ST, Kollef KE, Reichley RM, Roubinian N, Kollef MH. Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother 2007, 51(10):3568-3573. 10.1128/AAC.00851-07, 2043297, 17682100.
6. Schramm GE, Johnson JA, Doherty JA, Micek ST, Kollef MH. Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment. Crit Care Med 2006, 34(8):2069-2074. 10.1097/01.CCM.0000227655.41566.3E, 16763516.
7. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 2000, 118(1):146-155. 10.1378/chest.118.1.146, 10893372.
8. Alvarez-Lerma F. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. ICU-Acquired Pneumonia Study Group. Intensive Care Med 1996, 22(5):387-394.
9. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002, 122(1):262-268. 10.1378/chest.122.1.262, 12114368.
10. Zilberberg MD, Shorr AF, Micek ST, Mody SH, Kollef MH. Antimicrobial therapy escalation and hospital mortality among patients with health-care-associated pneumonia: a single-center experience. Chest 2008, 134(5):963-968. 10.1378/chest.08-0842, 18641103.
11. Zilberberg MD, Shorr AF, Micek ST, Chen J, Ramsey AM, Hoban AP, et al. Hospitalizations with healthcare-associated complicated skin and skin structure infections: impact of inappropriate empiric therapy on outcomes. J Hosp Med 2010, 5(9):535-540. 10.1002/jhm.713, 20734456.
12. Lipsky BA, Weigelt JA, Gupta V, Killian A, Peng MM. Skin, soft tissue, bone, and joint infections in hospitalized patients: epidemiology and microbiological, clinical, and economic outcomes. Infect Control Hosp Epidemiol 2007, 28(11):1290-1298. 10.1086/520743, 17926281.
13. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, et al. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 1996, 22(7):707-710. 10.1007/BF01709751, 8844239, On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
14. Austin PC, Tu J. Bootstrap methods for developing predictive models. Am Stat 2004, 58:131-137.
15. Guidelines for the management of adults with hospital-acquired ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 171(4):388-416.
16. Fagan TJ. Letter: Nomogram for Bayes theorem. N Engl J Med 1975, 293(5):257.
17. Shorr AF, Zilberberg MD, Micek ST, Kollef MH. Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med 2008, 168(20):2205-2210. 10.1001/archinte.168.20.2205, 19001196.
18. Shorr AF, Zilberberg MD, Reichley R, Kan J, Hoban A, Hoffman J, et al. Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department. Clin Infect Dis 2012, 54(2):193-198. 10.1093/cid/cir813, 22109951.
19. Zilberberg MD, Shorr AF, Micek ST, et al. Epidemiology and outcomes of hospitalizations with complicated skin and skin structure infections: Implications of healthcare associated infection risk factors. Infect Control Hosp Epidemiol 2009, 30:1203-10. 10.1086/648083, 19848604.
20. Schreiber MP, Chan CM, Shorr AF. Resistant pathogens in nonnosocomial pneumonia and respiratory failure: is it time to refine the definition of health-care-associated pneumonia?. Chest 2010, 137(6):1283-1288. 10.1378/chest.09-2434, 20154075.
21. Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, Goldstein EJ, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 2005, 41(10):1373-1406. 10.1086/497143, 16231249.
22. Edelsberg J, Berger A, Weber DJ, Mallick R, Kuznik A, Oster G. Clinical and economic consequences of failure of initial antibiotic therapy for hospitalized patients with complicated skin and skin-structure infections. Infect Control Hosp Epidemiol 2008, 29(2):160-169. 10.1086/526444, 18179372.