Epidemiology and outcomes of hospitalizations with complicated skin and skin-structure infections: Implications of healthcare-associated infection risk factors

Infection Control and Hospital Epidemiology

Volumn 30, Issue 12, 2009, Pages 1203-1210

  Zilberberg, Marya D ^a,b   Shorr, Andrew F ^c   Micek, Scott T ^d   Hoban, Alex P ^d   Pham, Victor ^e   Doherty, Joshua A ^e   Ramsey, Andrew M ^b   Kollef, Marin H ^d  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b EviMed Research Group LLC   (United States)

^c WASHINGTON HOSPITAL CENTER   (United States)

^d BARNES JEWISH HOSPITAL   (United States)

^e BJC HEALTHCARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; COHORT ANALYSIS; CORRELATION ANALYSIS; DRUG TREATMENT FAILURE; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMODIALYSIS; HOSPITAL INFECTION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INFECTION COMPLICATION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MORTALITY; NURSING HOME; PROGNOSIS; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SKIN INFECTION; SKIN STRUCTURE INFECTION; TREATMENT OUTCOME;

ADULT; ANTI-BACTERIAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HOSPITALIZATION; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SKIN DISEASES, BACTERIAL; TREATMENT OUTCOME;

EID: 73449136390     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/648083     Document Type: Article

References (30)

1. Klein E, Smith DL, Laxminarayan R. Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005. Emerg Infect Dis 2007;13:1840-1846.
2. Fridkin SK, Gaynes RP. Antimicrobial resistance in intensive care units. Clin Chest Med 1999;20:303-316.
3. Klevens RM, Edwards JR, Tenover FC, McDonald LC, Horan T, Gaynes R. Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003. Clin Infect Dis 2006;42:389-391.
4. Razavi B, Apisarnthanarak A, Mundy LM. Clostridium difficile: Emergence of hypervirulence and fluoroquinolone resistance. Infection 2007;35:300-7.
5. Dellit TH, Owens RC, McGowan JE, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 2007;44:159-177.
6. Spellberg B, Guidos R, Gilbert D, et al. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis 2008;46:155-164.
7. Micek ST, Kollef KE, Reichley RM, et al. Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother 2007;51:3568-73.
8. Schramm GE, Johnson JA, Doherty JA, et al. Methicillin-resistant Staphylococcus aureus sterile-site infection: the importance of appropriate initial antimicrobial treatment. Crit Care Med 2006;34:2069-2074.
9. Ibrahim EH, Sherman G, Ward S, et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 2000;118:146-155.
10. Alvarez-Lerma F, ICU-acquired Pneumonia Study Group. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. Intensive Care Med 1996;22:387-394.
11. Iregui M, Ward S, Sherman G, et al. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002;122:262-268.
12. Zilberberg MD, Shorr AF, Micek MT, Mody SH, Kollef MH. Antimicrobial therapy escalation and hospital mortality among patients with HCAP: A single center experience. Chest 2008;134:963-8.
13. Lipsky BA, Weigelt JA, Gupta V, et al. Skin, soft tissue, bone, and joint infections in hospitalized patients: Epidemiology and microbiological, clinical, and economic outcomes. Infect Control Hosp Epidemiol 2007;28:1290-1298.
14. National Nosocomial Infections Surveillance (NNIS) System Report. Am J Infect Control 2004;32:470.
15. Obritsch MD, Fish DN, MacLaren R, Jung R. National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002. Antimicrob Agents Chemother 2004;48:4606-10.
16. Edelsberg J, Berger A, Weber DJ, Mallick R, Kuznik A, Oster G. Clinical and economic consequences of failure of initial antibiotic therapy for hospitalized patients with complicated skin and skin-structure infections. Infect Control Hosp Epidemiol 2008;29:160-169.
17. Hospital-Acquired Pneumonia Guideline Committee of the American Thoracic Society and Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired pneumonia, ventilator-associated pneumonia, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416.
18. Kollef MH, Shorr A, Tabak YP, et al. Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest 2005;128:3854-3862.
19. Friedman ND, Kaye KS, Stout JE, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002;137:791-797.
20. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis 2005;41:1373-1406.
21. Carratala J, Mykietiuk A, Fernandez-Sabe N, et al. Health care-associated pneumonia requiring hospital admission: epidemiology, antibiotic therapy and clinical outcomes. Arch Intern Med 2007;167:1393-1399.
22. Shindo Y, Sato S, Muruyama E, et al. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital. Chest 2009;135:633-640.
23. Morin CA, Hadler JL. Population-based incidence and characteristics of community-onset Staphylococcus aureus infections with bacteremia in 4 metropolitan Connecticut areas, 1998. J Infect Dis 2001;184:1029-34.
24. Friedman ND, Kaye KS, Stout JE, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002;137:791-797.
25. Siegman-Igra Y, Fourer B, Orni-Wasserlauf R, et al. Reappraisal of community-acquired bacteremia: a proposal of a new classification for the spectrum of acquisition of bacteremia. Clin Infect Dis 2002;34:1431-9.
26. McDonald JR, Friedman ND, Stout JE, et al. Risk factors for ineffective therapy in patients with bloodstream infections. Arch Intern Med 2005;165:308-313.
27. Naimi TS, LeDell KH, Como-Sabetti K, et al. Comparison of communityand health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 2003;290:2976-84.
28. Tambyah PA, Habib AG, Ng TM, et al. Community-acquired methicillinresistant Staphylococcus aureus infection in Singapore is usually "healthcare associated." Infect Control Hosp Epidemiol 2003;24:436-8.
29. Shorr AF, Tabak YP, Killian AD, et al. Healthcare-associated bloodstream infection: a distinct entity? Insights from a large US database. Crit Care Med 2006;34:2588-95.
30. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infection among patients in the emergency department. N Engl J Med 2006;355:666-74.