Molecular characterization and mutational analysis of recombinant diadenosine 5′,5″-P1,P4-tetraphosphate hydrolase from Plasmodium falciparum

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 7, 2012, Pages 1191-1196

  Osman, Waleed ^a   Endo, Satoshi ^b   Oh hashi, Kentaro ^a   Kitamura, Yoshiaki ^a   Kitade, Yukio ^a  

^a GIFU UNIVERSITY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Ap4A hydrolase; Chemotherapeutic; Diadenosine tetraphosphate; Malaria; Mutational analysis; Plasmodium

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALANINE; MAGNESIUM ION; PHENYLALANINE; PROLINE; RECOMBINANT DIADENOSINE 5',5'' P1,P4 TETRAPHOSPHATE HYDROLASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN VERSUS NONHUMAN DATA; MOLECULAR MODEL; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PH MEASUREMENT; PLASMODIUM FALCIPARUM; PROTEIN EXPRESSION; RESIDUE ANALYSIS; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; TEMPERATURE SENSITIVITY; THERMODYNAMICS; THERMOSTABILITY; WILD TYPE;

ACID ANHYDRIDE HYDROLASES; AMINO ACID SEQUENCE; ANIMALS; DINUCLEOSIDE PHOSPHATES; DNA MUTATIONAL ANALYSIS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMODIUM FALCIPARUM; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 84863551433     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00165     Document Type: Article

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