Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-l-homocysteine hydrolase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3809-3815

  Ando, Takayuki ^a   Iwata, Masafumi ^a   Zulfiqar, Fazila ^a   Miyamoto, Tatsuya ^a   Nakanishi, Masayuki ^a   Kitade, Yukio ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

2 Fluoroaristeromycin; Carbocyclic nucleoside; Enzyme inhibitor; S Adenosyl l homocysteine hydrolase

Indexed keywords

2 FLUOROARISTEROMYCIN; 9 (10 HYDROXYMETHYLCYCLOPENTAN 3' YL) 9H 2 FLUOROADENINE; 9 (2' HYDROXY 4' HYDROXYMETHYLCYCLOPENTAN 10 YL) 9H 2 FLUOROADENINE; 9 (2',3' DIHYDROXY 4' HYDROXYMETHYLCYCLOPENTAN 10 YL) 9H 2 AMINOADENINE; 9 (2',3' DIHYDROXY 4' HYDROXYMETHYLCYCLOPENTAN 10 YL) 9H 2 FLUOROADENINE; 9 (2',3' EPOXY 4' HYDROXYMETHYLCYCLOPENTAN 10 YL) 9H 2 FLUOROADENINE; ADENOSINE DEAMINASE; ADENOSYLHOMOCYSTEINASE INHIBITOR; ARISTEROMYCIN; ARISTEROMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL MODIFICATION; HYDROGENATION; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; ANIMALS; ANTIMALARIALS; ENZYME INHIBITORS; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 41649083951     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.046     Document Type: Article

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