Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 303, Issue 1, 2012, Pages

  Cheng, Sam X ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Secretory diarrhea; Short circuit current

Indexed keywords

CALCIUM SENSING RECEPTOR; CYCLIC AMP; FORSKOLIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; TECALCET; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIARRHEA; DRUG EFFECT; ELECTROLYTE TRANSPORT; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INTESTINE INNERVATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHORT CIRCUIT CURRENT;

ANILINE COMPOUNDS; ANIMALS; BUMETANIDE; CHLORIDES; COLON; DIFFUSION CHAMBERS, CULTURE; DIURETICS; ELECTROLYTES; ENTERIC NERVOUS SYSTEM; FORSKOLIN; IMMUNOHISTOCHEMISTRY; INTESTINES; MALE; MYENTERIC PLEXUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCIUM-SENSING; SUBMUCOUS PLEXUS; TETRODOTOXIN; TUBULIN;

EID: 84863536007     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00425.2011     Document Type: Article

References (44)

1. Alam Mu Kirton J, Wilkinson F, Towers E, Sinha S, Rouhi M, Vizard T, Sage A, Martin D, Ward D, Alexander M, Riccardi D, Canfield A. Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res 81: 260-268, 2009.
2. Black R, Cousens S, Johnson H, Lawn J, Rudan I, Bassani D, Jha P, Campbell H, Walker C, Cibulskis R, Eisele T, Liu L, Mathers C; Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 375: 1969-1987, 2010.
3. Bovee-Oudenhoven IMJ, Lettink-Wissink MLG, Van Doesburg W, Witteman BJM, Van Der Meer R. Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium. Gastroenterology 125: 469-476, 2003.
4. 2+-sensing receptor from bovine parathyroid. Nature 366: 575-580, 1993.
5. Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81: 239-297, 2001.
6. Burleigh DE, Borman RA. Evidence for a nonneural electrogenic effect of cholera toxin on human isolated ileal mucosa. Dig Dis Sci 42: 1964-1968, 1997.
7. Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan L, Shoback D. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J Biol Chem 282: 25030-25040, 2007.
8. 2+-sensing receptor in rat intestine. Am J Physiol Gastrointest Liver Physiol 274: G122-G130, 1998.
9. Chen W, Bergsman J, Wang X, Gilkey G, Pierpoint CR, Daniel E, Awumey E, Dauban P, Dodd R, Ruat M, Smith S. Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals. PLoS ONE 5: e8563, 2010.
10. Cheng SX, Geibel J, Hebert S. Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor. Gastroenterology 126: 148-158, 2004.
11. Cheng SX, Okuda M, Hall A, Geibel JP, Hebert SC. Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion. Am J Physiol Gastrointest Liver Physiol 283: G240-G250, 2002.
12. Clarke L. A guide to Ussing chamber studies of mouse intestine. Am J Physiol Gastrointest Liver Physiol 296: G1151-G1166, 2009.
13. Cooke H, Wang YZ, Wray D, O'Dorisio MS, Woltering E, Coy D, Murphy W, Christofi F, Gosh P, O'Dorisio T. A multi-tyrosinated sst1/2 receptor preferring somatostatin agonist inhibits reflex and immunemediated secretion in the guinea pig colon. Regul Pept 114: 51-60, 2003.
14. Cooke HJ. Neurotransmitters in neuronal reflexes regulating intestinal secretion. Ann NY Acad Sci 915: 77-80, 2000.
15. Cox HM, Cuthbert AW, Hkanson R, Wahlestedt C. The effect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia. J Physiol 398: 65-80, 1988.
16. Currie MG, Fok KF, Kato J, Moore RJ, Hamra FK, Duffin KL, Smith CE. Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci USA 89: 947-951, 1992.
17. Field M. Intestinal ion transport and the pathophysiology of diarrhea. J Clin Invest 111: 931-943, 2003.
18. Field M, Graf LH, Laird WJ, Smith PL. Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc Natl Acad Sci USA 75: 2800-2804, 1978.
19. Flores J, Sharp G. The activation of adenylate cyclase by cholera toxin: possible interaction with the nucleotide regulatory site. Ciba Found Symp 42: 89-108, 1976.
20. 2+-sensing receptors in intestinal epithelium. Am J Physiol Cell Physiol 273: C1168-C1175, 1997.
21. Geibel J, Sritharan K, Geibel R, Geibel P, Persing JS, Seeger A, Roepke T, Deichstetter M, Prinz C, Cheng S, Martin D, Hebert S. Calcium-sensing receptor abrogates secretagogue-induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proc Natl Acad Sci USA 103: 9390-9397, 2006.
22. 2+receptor: characterization and use in studying concanavalin A inhibition. J Bone Miner Res 12: 1780-1788, 1997.
23. Guarino A, Albano F, Guandalini S. Oral rehydration: toward a real solution. J Pediatr Gastroenterol Nutr 33, Suppl 2: S2-S12, 2001.
24. 2+receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568. Mol Pharmacol 53: 1083-1088, 1998.
25. 2+sensing receptor in the gastrointestinal tract. Cell Calcium 35: 239-247, 2004.
26. Lorrot M, Vasseur M. How do the rotavirus NSP4 and bacterial enterotoxins lead differently to diarrhea? Virol J 4: 31, 2007.
27. Lundgren O. Enteric nerves and diarrhoea. Pharmacol Toxicol 90: 109-120, 2002.
28. Lundgren O, Peregrin AT, Persson K, Kordasti S, Uhnoo I, Svensson L. Role of the enteric nervous system in the fluid and electrolyte secretion of rotavirus diarrhea. Science 287: 491-495, 2000.
29. Margolis KG, Stevanovic K, Karamooz N, Li ZS, Ahuja A, D'autreaux F, Saurman V, Chalazonitis A, Gershon MD. Enteric neuronal density contributes to the severity of intestinal inflammation. Gastroenterology 141: 588-598, 2011.
30. Moore S, Lima AAM, Guerrant R. Infection: preventing 5 million child deaths from diarrhea in the next 5 years. Nat Rev Gastroenterol Hepatol 8: 363-364, 2011.
31. Nakajima K, Tooyama I, Kuriyama K, Kimura H. Immunohistochemical demonstration of GABAB receptors in the rat gastrointestinal tract. Neurochem Res 21: 211-215, 1996.
32. Nearing J, Betka M, Quinn S, Hentschel H, Elger M, Baum M, Bai M, Chattopadyhay N, Brown EM, Hebert SC, Harris HW. Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. Proc Natl Acad Sci USA 99: 9231-9236, 2002.
33. Phillips C, Harnett M, Chen W, Smith S. Calcium-sensing receptor activation depresses synaptic transmission. J Neurosci 28: 12062-12070, 2008.
34. Riccardi D, Park J, Lee WS, Gamba G, Brown EM, Hebert SC. Cloning and functional expression of a rat kidney extracellular calcium/ polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 92: 131-135, 1995.
35. Ruat M, Molliver ME, Snowman AM, Snyder SH. Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc Natl Acad Sci USA 92: 3161-3165, 1995.
36. Sands JM, Naruse M, Baum M, Jo I, Hebert SC, Brown EM, Harris HW. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest 99: 1399-1405, 1997.
37. Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res 7: 201-224, 1981.
38. Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. J Histochem Cytochem 48: 595-602, 2000.
39. Tfelt-Hansen J, Brown E. The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit Rev Clin Lab Sci 42: 35-70, 2005.
40. Tornehave D, Hougaard DM, Larsson L. Microwaving for double indirect immunofluorescence with primary antibodies from the same species and for staining of mouse tissues with mouse monoclonal antibodies. Histochem Cell Biol 113: 19-23, 2000.
41. Wang M, Yao Y, Kuang D, Hampson D. Activation of family C G-protein-coupled receptors by the tripeptide glutathione. J Biol Chem 281: 8864-8870, 2006.
42. Weston A, Absi M, Ward D, Ohanian J, Dodd R, Dauban P, Petrel C, Ruat M, Edwards G. Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circ Res 97: 391-398, 2005.
43. Wickelgren I. How rotavirus causes diarrhea. Science 287: 409, 411-409, 411, 2000.
44. Wood JD. Histamine, mast cells, and the enteric nervous system in the irritable bowel syndrome, enteritis, and food allergies. Gut 55: 445-447, 2006.