Heartworms, macrocyclic lactones, and the specter of resistance to prevention in the United States

Parasites and Vectors

Volumn 5, Issue 1, 2012, Pages

  Bowman, Dwight D ^a  

^a Cornell University ^*  (United States)

Author keywords

Dirofilaria immitis; Drug resistance; Heartworm; Ivermectin; Macrocyclic lactones; Milbemycin oxime; Moxidectin; Selamectin

Indexed keywords

INTERCEPTOR; IVERMECTIN; MACROLIDE; MELARSOMINE; MILBEMYCIN; SENTINEL; TRIFEXIS; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; DIROFILARIASIS; DOG DISEASE; DRUG EFFICACY; HAEMONCHUS CONTORTUS; HUMAN; INFECTION CONTROL; INFECTION PREVENTION; INFECTION SENSITIVITY; NEMATODE LIFE CYCLE STAGE; NONHUMAN; PARASITE CLEARANCE; REVIEW; UNITED STATES;

ANIMALS; ANTHELMINTICS; DIROFILARIA IMMITIS; DOG DISEASES; DOGS; DRUG RESISTANCE; LACTONES; UNITED STATES;

ANIMALIA; CANIS FAMILIARIS; DIROFILARIA IMMITIS; VERMES;

EID: 84863525066     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/1756-3305-5-138     Document Type: Review

References (29)

1. NADA, 138-412 Heartgard-30 http://www.fda.gov/AnimalVeterinary/Products/ ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm111205.htm?utm-campaign= Google2&utm-source=fdaSearch&utm-medium=website&utm-term= nada%20138-412&utm-content=1 138
2. NADA, 140-915 Interceptor http://www.fda.gov/AnimalVeterinary/Products/ ApprovedAnimalDrugProducts/ FOIADrugSummaries/ucm054857.htm?utm-campaign= Google2&utm-source=fdaSearch&utm-medium=website&utm-term= nada%20140-915&utm-content=5 140
3. NADA, 141-152 Revolution http://www.fda.gov/downloads/ AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ ucm117201.pdf 141
4. NADA, 141-051 ProHeart for Dogs http://www.fda.gov/AnimalVeterinary/ Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm116537.htm 141
5. NADA, 141-189 ProHeart6 http://www.fda.gov/downloads/ AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ ucm117588.pdf 141
6. NADA, 141-252 Advantage Multi for Dogs http://www.fda.gov/downloads/ AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ UCM051438.pdf 141
7. The effects of ivermectin on transmission of Onchocerca volvulus. Cupp EW, Bernardo MJ, Kiszewski AE, Collins RC, Taylor HR, Aziz MA, Greene BM, Science 1986 231 740 742 10.1126/science.3753801 3753801 (Pubitemid 16104049)
8. Identifying sub-optimal responses to ivermectin in the treatment of River Blindness. Churcher TS, Pion SD, Osei-Atweneboana MY, Prichard RK, Awadzi K, Boussinesq M, Collins RC, Whitworth JA, Basanez MG, Proc Natl Acad Sci USA 2009 106 16716 16721 10.1073/pnas.0906176106 19805362
9. The problem of anthelmintic resistance in nematodes. Prichard RK, Hall CA, Kelly JD, Martin ICA, Donald AD, Aust Vet J 1980 56 239 250 10.1111/j.1751-0813.1980.tb15983.x 7002142
10. Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus. Williamson SM, Storey B, Howell S, Harper KM, Kaplan RM, Wolstenholme AJ, Mol Biochem Parasitol 2011 180 99 105 10.1016/j.molbiopara.2011.09.003 21945142
11. Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses. Reinemeyer CR, Prado JC, Nichols EC, Marchiondo AA, Vet Parasitol 2010 171 111 115 10.1016/j.vetpar.2010.02.041 20307936
12. Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany. Traversa D, Samson-Himmelstjerna G, Demeler J, Milillo P, Schurmann S, Barnes H, Otranto D, Perrucci S, Regalbono AF, Beraldo P, Boeckh A, Cobb R, Parasit Vectors 2009 2 Suppl 2 2 10.1186/1756-3305-2-S2-S2 19778463
13. Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep. Kaminsky R, Bapst B, Stein PA, Strehlau GA, Allan BA, Hosking BC, Rolfe PF, Sager H, Parasitol Res 2011 109 19 23 10.1007/s00436-010-2216-0 21161271
14. Drug resistance in veterinary helminths. Wolstenholme AJ, Fairweather I, Prichard R, Samson-Himmelstjerna G, Sangster NC, Trends Parasitol 2004 20 469 476 10.1016/j.pt.2004.07.010 15363440 (Pubitemid 39195056)
15. A modified larval migration assay for detection of resistance to macrocyclic lactones in Haemonchus contortus, and drug screening with Trichostrongylidae parasites. Kotze AC, le Jambre LF, OGrady J, Vet Parasitol 2006 137 294 305 10.1016/j.vetpar.2006.01.017 16472922
16. Atkins C, Current controversies and dilemmas in heartworm disease: defining the issues by close examination https://www.aahanet.org/Education/ WebConference.aspx?key=428166ce-8c29-462d-ad51-f7b9bd3b1350
17. Evaluation of susceptibility of heartworm (Dirofilaria immitis) biotypes to macrocyclic lactones using microfilariae-based single dose and dose-mortality regression assays [abstract]. Blagburn BL, Vaughan JL, Butler JM, Mount JD, Spencer JA, Carmichael J, Schenker R, Proceedings of the AAVP 56th Annual Meeting St. Louis, MO 2011 110 16-19 July 2011
18. Macrocyclic lactone resistance in Dirofilaria immitis. Bourguinat C, Keller K, Bhan A, Peregrine A, Geary T, Prichard R, Vet Parastiol 2011 181 388 392 10.1016/j.vetpar.2011.04.012
19. In vitro bioassay for measuring anthelmintic susceptibility in Dirofilaria immitis [abstract]. Moorhead AD, Evans CC, Wolstenholm AJ, Storey BE, Blagburn BL, Vaughan JL, Schenker R, Carmichael J, Kaplan RM, Proceedings of the AAVP 56th Annual Meeting St. Louis, MO 2011 109 16-19 July 2011
20. Ivermectin and milbemycin oxime in experimental adult heartworm (Dirofilaria immitis) infection of dogs. Snyder DE, Wiseman S, Cruthers LR, Slone RL, J Vet Intern Med 2011 25 61 64 10.1111/j.1939-1676.2010.0657.x 21155893
21. Assessment of the effectiveness of a combination product of spinosad and milbemycin oxime on the prophylaxis of canine heartworm infection. Snyder DE, Wiseman S, Bowman DD, McCall JW, Reinemeyer CR, Vet Parasitol 2011 180 262 266 10.1016/j.vetpar.2011.03.034 21530085
22. NADA, 141-321 Trifexis http://www.fda.gov/downloads/AnimalVeterinary/ Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM252248.pdf? utm-campaign=Google2&utm-source=fdaSearch&utm-medium= website&utm-term=nada trifexis&utm-content=1 141
23. Comparative efficacy of four commercially available heartworm preventive products against the MP3 laboratory strain of Dirofilaria immitis. Blagburn BL, Dillon AR, Arther RG, Butler JM, Newton JC, Vet Parasitol 2011 176 189 194 10.1016/j.vetpar.2010.12.049 21295409
24. NADA, 141-333 Sentinel Spectrum http://www.fda.gov/downloads/ AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ UCM292003.pdf 141
25. Genetic polymorphism in Dirofilaria immitis. Bourguinat C, Keller K, Prichard RK, Geary TG, Vet Parasitol 2011 176 368 373 10.1016/j.vetpar.2011.01. 023 21310534
26. Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype. Bourguinat C, Keller K, Blagburn B, Schenker R, Geary TG, Prichard RK, Vet Parasitol 2011 176 374 381 10.1016/j.vetpar.2011.01.024 21300438
27. Macrocyclic lactone resistance in Dirofilaria immitis [abstract]. Bourguinat C, Keller K, Bhan A, Peregrine AS, Blagburn BL, Geary TG, Prichard RK, Proceedings of the AAVP 56th Annual Meeting St. Louis, MO 2011 108 16-19 July 2011
28. Inference of population structure and patterns of gene flow in canine heartworm (Dirofilaria immitis). Belanger DH, Perkins SL, Rockwell RF, J Parasitol 2011 97 602 609 10.1645/GE-2679.1 21506823
29. Heartworm and Wolbachia: therapeutic implications. McCall JW, Genchi C, Kramer L, Guerrero J, Dzimianski MT, Supakorndej P, Mansour AM, McCall SD, Supakorndej N, Grandi G, Carson B, Vet Parasitol 2008 158 204 14 10.1016/j.vetpar.2008.09.008 18930598