Macrocyclic lactone resistance in Dirofilaria immitis

Veterinary Parasitology

Volumn 181, Issue 2-4, 2011, Pages 388-392

  Bourguinat, Catherine ^a   Keller, Kathy ^a   Bhan, Aron ^b   Peregrine, Andrew ^c   Geary, Timothy ^a   Prichard, Roger ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Main West Animal Hospital   (Canada)

^c UNIVERSITY OF GUELPH   (Canada)

Author keywords

Anthelmintic resistance; Dirofilaria immitis; Heartworm; Heartworm preventative; Ivermectin; Macrocyclic lactone

Indexed keywords

GLYCOPROTEIN P; IMMITICIDE; INTERCEPTOR; IVERMECTIN; MACROLIDE; MELARSOMINE; MILBEMYCIN OXIME; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION ANALYSIS; DIROFILARIA IMMITIS; DIROFILARIASIS; DOG; DRUG RESISTANCE; DRUG SENSITIVITY; GENOTYPE; IN VITRO STUDY; MALE; MICROFILARIA (NEMATODE LARVA); NONHUMAN; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ANTHELMINTICS; DIROFILARIA IMMITIS; DIROFILARIASIS; DOG DISEASES; DOGS; DRUG RESISTANCE; LACTAMS, MACROCYCLIC; MALE; POLYMORPHISM, GENETIC;

CANIS FAMILIARIS; DIROFILARIA IMMITIS;

EID: 80052536744     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2011.04.012     Document Type: Article

References (27)

1. American Heartworm Society, 2010. Diagnosis, prevention and management of heartworm infection in dogs: guidelines, canine heartworm disease. http://www.heartwormsociety.org/veterinary-resources/canine-guidelines.html.
2. Ardelli B.F., Guerriero S.B., Prichard R.K. Characterization of a half-size ATP-binding cassette transporter gene which may be a useful marker for ivermectin selection in Onchocerca volvulus. Mol. Biochem. Parasitol. 2006, 145:94-100.
3. Atkins C. Canine heartworm disease: current treatment and prevention approaches. The 26th Annual WALTHAM®Diets/OSU Symposium, Small Animal Cardiology 2002.
4. Blackhall W., Liu H.Y., Xu M., Prichard R.K., Beech R.N. Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus. Mol. Biochem. Parasitol. 1998, 95:193-201.
5. Blagburn B.L., Dillon A.R., Arthur R.G., Butler J.M., Newton J.C. Comparative efficacy of four commercially available heartworm preventive products against the MP3 laboratory strain of Dirofilaria immitis. Vet. Parasitol. 2011, 176:189-194.
6. Boersema J.H., Eysker M., Nas J.W. Apparent resistance of Parascaris equorum to macrocylic lactones. Vet. Rec. 2002, 150:279-281.
7. Bourguinat C., Ardelli B.F., Pion S.D.S., Kamgno J., Gardon J., Duke B.O.L., Boussinesq M., Prichard R.K. P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus. Mol. Biochem. Parasitol. 2008, 158:101-111.
8. Bourguinat C., Keller K., Blagburn B., Schenker R., Geary T.G., Prichard R.K. Correlation between loss of efficacy of macrocyclic lactone heartworm preventatives and P-glycoprotein genotype. Vet. Parasitol. 2011, 176:374-381.
9. Bourguinat C., Keller K., Prichard R.K., Geary T.G. Genetic polymorphism in Dirofilaria immitis. Vet. Parasitol. 2011, 176:368-373.
10. Bowman D.D., Atkins C.E. Heartworm biology, treatment, and control. Vet. Clin. North Am. Small Anim. Pract. 2009, 39:1127-1158.
11. Bowman D.D., Johnson R.C., Ulrich M.E., Neumann N., Lok J.B., Zhang Y., Knight D.H. Effects of long-term administration of ivermectin and milbemycin oxime on circulating microfilariae and parasite antigenemia in dogs with patent heartworm infections. Proceedings of the Heartworm Symposium '92 1992, 151-158. Amer. Heartworm Soc., Batavia, IL. M.D. Soll (Ed.).
12. Bowman, D.D., Torre, C.J., 2006. The effects of preventative dosages of macrolide treatments on circulating microfilariae in dogs with patent heartworm-Dirofilaria immitis-infections. US Companion Animal Health, pp. 9-11.
13. Churcher T.S., Schwab A.E., Prichard R.K., Basáñez M.-G. An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance. PLoS Neg. Trop. Dis. 2008, 2(1-9):e211.
14. Courtney C.H., Zeng Q.T., Maler M.M. The effect of chronic administration of milbemycin oxime and ivermectin on microfilaremias in heartworm-infected dogs. Recent Advances in Heartworm Disease: Symposium '98 1998, 193-199. Amer. Heartworm Soc., Batavia, IL. R.L. Seward (Ed.).
15. Hampshire V.A. Evaluation of efficacy of heartworm preventive products at the FDA. Vet. Parasitol. 2005, 133:191-195.
16. Hearn F.P., Peregrine A.S. Identification of foals infected with Parascaris equorum apparently resistant to ivermectin. J. Am. Vet. Med. Assoc. 2003, 223:482-485.
17. Kaplan R.M. Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol. 2004, 20:477-481.
18. McCall J.W. The safety-net story about macrocyclic lactone heartworm preventives: a review, an update, and recommendations. Vet. Parasitol. 2005, 133:197-206.
19. McCall J.W., Ryan W.G., Roberts R.E., Dzimianski M.T. Heartworm adulticidal activity of prophylactic doses of ivermectin (6μg/kg) plus pyrantel administered monthly to dogs. Recent Advances in Heartworm Disease: Symposium '98 1998, 209-215. Amer. Heartworm Soc., Batavia, IL. R.L. Seward (Ed.).
20. McManus E.C., Pulliam J.D. Histopathologic features of canine heartworm microfilarial infection after treatment with ivermectin. Am. J. Vet. Res. 1984, 45:91-97.
21. Osei-Atweneboana M.Y., Awadzi K., Attah S.K., Boakye D.A., Gyapong J.O., Prichard R.K. Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus. PLoS Neg. Trop. Dis. 2011, 5(3):e998. 10.1371/journal.pntd.0000998.
22. Osei-Atweneboana M.Y., Eng J.K.L., Boakye D.A., Gyapong J.O., Prichard R.K. Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin after 19 years of treatment in endemic communities in Ghana. Lancet 2007, 369:2021-2029.
23. Prichard R.K. Is anthelmintic resistance a concern for heartworm control? What can we learn from the human filariasis control programs?. Vet. Parasitol. 2005, 133:243-253.
24. Snyder D.E., Wiseman S., Cruthers L.R., Slone R.L. Ivermectin and milbemycin oxime in experimental adult heartworm (Dirofilaria immitis) infection of dogs. J. Vet. Intern. Med. 2011, 25:61-64.
25. Venco L., McCall J.W., Guerrero J., Genchi C. Efficacy of long-term monthly administration of ivermectin on the progress of naturally acquired heartworm infections in dogs. Vet. Parasitol. 2004, 124:259-268.
26. Wolstenholme A.J., Fairweather I., Prichard R.K., von Samson-Himmelstjerna G., Sangster N.C. Drug resistance in veterinary helminths. Trends Parasitol. 2004, 20:469-476.
27. Xu M., Molento M., Blackhall W., Ribeiro P., Beech R., Prichard R. Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. Mol. Biochem. Parasitol. 1998, 91:327-335.