Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis

Liver International

Volumn 32, Issue 7, 2012, Pages 1079-1092

  Lockman, Khalida A ^a   Baren, James P ^a   Pemberton, Christopher J ^a   Baghdadi, Hussam ^a   Burgess, Karl E ^b   Plevris Papaioannou, Nikolas ^a   Lee, Patricia ^a   Howie, Forbes ^a   Beckett, Geoff ^a   Pryde, Anne ^a   Jaap, Alan J ^a   Hayes, Peter C ^a   Filippi, Celine ^a   Plevris, John N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Mitochondrial dysfunction; N acetylcysteine; Nonalcoholic fatty liver disease; Oxidative stress; Reactive oxygen species; Steatohepatitis

Indexed keywords

ACETYLCYSTEINE; AMMONIA; GLUCOSE; GLUTATHIONE PEROXIDASE 1; LACTATE DEHYDROGENASE; LACTIC ACID; OCTANOIC ACID; OLEIC ACID; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE; TRIACYLGLYCEROL;

ARTICLE; BIOACCUMULATION; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; FATTY LIVER; FLUORESCENCE ANALYSIS; GLUCONEOGENESIS; HEPATOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; KETOGENESIS; LIPID PEROXIDATION; LIPOGENESIS; LIVER MITOCHONDRION; METABOLOMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS;

ACETYLCYSTEINE; ANTIOXIDANTS; CELL LINE, TUMOR; CELL RESPIRATION; FATTY LIVER; GLUCONEOGENESIS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TRIGLYCERIDES;

EID: 84863522604     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2012.02775.x     Document Type: Article

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