Impaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage at the plasma membrane instead of the endoplasmic reticulum

Molecules and Cells

Volumn 33, Issue 3, 2012, Pages 251-257

  Bothe, Melanie K ^a   Mundhenk, Lars ^a   Beck, Carol L ^b   Kaup, Matthias ^c   Gruber, Achim D ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

CLCA protein; HEXXH zinc binding amino acid motif; Metalloprotease

Indexed keywords

CALCIUM ACTIVATED CHLORIDE CHANNEL REGULATOR 6 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE MUTATION; INTESTINE CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CELL MEMBRANE; CHELATING AGENTS; CHLORIDE CHANNELS; ENDOPLASMIC RETICULUM; ENTEROCYTES; HEK293 CELLS; HUMANS; METALLOPROTEASES; MICE; MUTAGENESIS, SITE-DIRECTED; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; ZINC;

MURINAE;

EID: 84863500966     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-012-2217-1     Document Type: Article

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