Upregulation of Shh and Ptc1 in hyperoxia-induced acute lung injury in neonatal rats

Molecular Medicine Reports

Volumn 6, Issue 2, 2012, Pages 297-302

  Dang, Hongxing ^a,b   Wang, Shaohua ^b,c   Yang, Lin ^a,b   Fang, Fang ^a,b   Xu, Feng ^a,b  

^a CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c NICU   (China)

Author keywords

Acute lung injury; Hyperoxia; Newborn; Ptc1 protein; Rat; Shh protein

Indexed keywords

EOSIN; HEMATOXYLIN; MESSENGER RNA; OXYGEN; PROTEIN PATCHED 1; RNA; SONIC HEDGEHOG PROTEIN;

ACUTE LUNG INJURY; AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; HYPEROXIA; IMMUNOHISTOCHEMISTRY; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ACUTE LUNG INJURY; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BODY WEIGHT; EOSINE YELLOWISH-(YS); FEMALE; HEDGEHOG PROTEINS; HEMATOXYLIN; HYPEROXIA; IMMUNOHISTOCHEMISTRY; LUNG; OXYGEN; PREGNANCY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAINING AND LABELING; TIME FACTORS; UP-REGULATION;

ERINACEIDAE; RATTUS;

EID: 84863487836     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.929     Document Type: Article

References (28)

1. Altemeier WA and Sinclair SE: Hyperoxia in the intensive care unit: why more is not always better. Curr Opin Crit Care 13: 73-78, 2007. (Pubitemid 46061280)
2. Demayo F, Minoo P, Plopper CG, Schuger L, Shannon J and Torday JS: Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process? Am J Physiol Lung Cell Mol Physiol 283: 510-517, 2002.
3. Severgnini M, Takahashi S, Rozo LM, et al: Activation of the STAT pathway in acute lung injury. Am J Physiol Lung Cell Mol Physiol 286: 1282-1292, 2004.
4. Severgnini M, Takahashi S, Tu P, et al: Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury. Am J Respir Crit Care Med 171: 858-867, 2005. (Pubitemid 40562716)
5. Tejera P, Wang Z, Zhai R, et al: Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome. Am J Respir Cell Mol Biol 41: 696-704, 2009.
6. Yum HK, Arcaroli J, Kupfner J, et al: Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol 167: 6601-6608, 2001. (Pubitemid 33081597)
7. Schuh K and Pahl A: Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury. Biochem Pharmacol 77: 1827-1834, 2009.
8. Moon C, Han JR, Park HJ, Hah JS and Kang JL: Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res 10: 18, 2009.
9. Damarla M, Hasan E, Boueiz A, et al: Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. PLoS One 4: e4600, 2009.
10. Watson S, Serrate C and Vignot S: Sonic hedgehog signaling pathway: from embryology to molecular targeted therapies. Bull Cancer 97: 1477-1483, 2010.
11. Jacob L and Lum L: Deconstructing the hedgehog pathway in development and disease. Science 318: 66-68, 2007. (Pubitemid 47538007)
12. Chang YS, Kim YJ, Yoo HS, et al: Alpha-phenyl-N-tert-butylnitrone attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats. Exp Lung Res 35: 234-249, 2009.
13. Tao W, Shu YS, Miao QB and Zhu YB: Attenuation of hyperoxia-induced lung injury in rats by adrenomedullin. Inflammation 35: 150-157, 2011.
14. Husari AW, Dbaibo GS, Bitar H, et al: Apoptosis and the activity of ceramide, Bax and Bcl-2 in the lungs of neonatal rats exposed to limited and prolonged hyperoxia. Respir Res 7: 100, 2006.
15. Murakami K, McGuire R, Cox RA, et al: Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep. Shock 18: 236-241, 2002.
16. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
17. Saugstad OD: Bronchopulmonary dysplasia-oxidative stress and antioxidants. Semin Neonatol 8: 39-49, 2003.
18. Spiteller G: The important role of lipid peroxidation processes in aging and age dependent diseases. Mol Biotechnol 37: 5-12, 2007.
19. Kunig AM, Balasubramaniam V, Markham NE, Seedorf G, Gien J and Abman SH: Recombinant human VEGF treatment transiently increases lung edema but enhances lung structure after neonatal hyperoxia. Am J Physiol Lung Cell Mol Physiol 291: 1068-1078, 2006.
20. Mill P, Mo R, Fu H, et al: Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev 17: 282-294, 2003. (Pubitemid 36105899)
21. Karhadkar SS, Bova GS, Abdallah N, et al: Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431: 707-712, 2004. (Pubitemid 39382619)
22. Kusano KF, Pola R, Murayama T, et al: Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med 11: 1197-1204, 2005. (Pubitemid 43093667)
23. Lavine KJ, Kovacs A and Ornitz DM: Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest 118: 2404-2414, 2008. (Pubitemid 351952997)
24. Omenetti A, Yang L, Li YX, et al: Hedgehog-mediated mesenchymal- epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest 87: 499-514, 2007. (Pubitemid 46633127)
25. Sicklick JK, Li YX, Melhem A, et al: Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol 290: G859-G870, 2006.
26. Wetmore C: Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models. Curr Opin Genet Dev 13: 34-42, 2003.
27. Stewart GA, Hoyne GF, Ahmad SA, et al: Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J Pathol 199: 488-495, 2003. (Pubitemid 36411226)
28. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA and Baylin SB: Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422: 313-317, 2003. (Pubitemid 36378358)