Glutamine prevents intestinal mucosal injury induced by cyclophosphamide in rats

Pediatric Surgery International

Volumn 28, Issue 3, 2012, Pages 299-303

  Owari, Mitsugu ^a   Wasa, Masafumi ^a   Oue, Takaharu ^a   Nose, Satoko ^a   Fukuzawa, Masahiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Chemotherapy; Glutamine; Glutathione; Intestine

Indexed keywords

BROXURIDINE; CYCLOPHOSPHAMIDE; GLUTAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; INTESTINAL MUCOSA INJURY; INTESTINE CELL; INTESTINE INJURY; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CYCLOPHOSPHAMIDE; DISEASE MODELS, ANIMAL; ENTEROCYTES; GLUTAMINE; ILEAL DISEASES; ILEUM; IN SITU NICK-END LABELING; INTESTINAL MUCOSA; MALE; RATS; RATS, WISTAR; TREATMENT OUTCOME;

EID: 84863479199     PISSN: 01790358     EISSN: 14379813     Source Type: Journal    
DOI: 10.1007/s00383-011-3023-0     Document Type: Article

References (23)

1. Santos GW (1990) Bone marrow transplantation in hematologic malignancies. Current status. Cancer 65(3 Suppl):786-791 (Pubitemid 20067263)
2. Daniele B, Secondulfo M, De Vivo R, Pignata S, De Magistris L, Delrio P, Palaia R, Barletta E, Tambaro R, Carratu R (2001) Effect of chemotherapy with 5-fluorouracil on intestinal permeability and absorption in patients with advanced colorectal cancer. J Clin Gastroenterol 32(3):228-230 (Pubitemid 32174115)
3. Duncan M, Grant G (2003) Oral and intestinal mucositis-causes and possible treatments. Aliment Pharmacol Ther 18(9):853-874 (Pubitemid 37346671)
4. Duggan C, Gannon J, Walker WA (2002) Protective nutrients and functional foods for the gastrointestinal tract. Am J Clin Nutr 75(5):789-808 (Pubitemid 34441247)
5. Oehler R, Roth E (2003) Regulative capacity of glutamine. Curr Opin Clin Nutr Metab Care 6(3):277-282 (Pubitemid 40684603)
6. Ziegler TR, Mantell MP, Chow JC, Rombeau JL, Smith RJ (1996) Gut adaptation and the insulin-like growth factor system: regulation by glutamine and igf-i administration. Am J Physiol 271(5 Pt 1):G866-G875
7. Anderson PM, Schroeder G, Skubitz KM (1998) Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer 83(7):1433-1439
8. Daniele B, Perrone F, Gallo C, Pignata S, De Martino S, De Vivo R, Barletta E, Tambaro R, Abbiati R, D'Agostino L (2001) Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut 48(1):28-33 (Pubitemid 32042638)
9. Neu J, DeMarco V, Li N (2002) Glutamine: clinical applications and mechanisms of action. Curr Opin Clin Nutr Metab Care 5(1):69-75
10. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150(1):76-85 (Pubitemid 16258399)
11. Song D, Shi B, Xue H, Li Y, Yang X, Yu B, Xu Z, Liu F, Li J (2006) Confirmation and prevention of intestinal barrier dysfunction and bacterial translocation caused by methotrexate. Dig Dis Sci 51(9):1549-1556 (Pubitemid 44379296)
12. Paulus SC, van Saene HK, Hemsworth S, Hughes J, Ng A, Pizer BL (2005) A prospective study of septicaemia on a paediatric oncology unit: a three-year experience at The Royal Liverpool Children's Hospital, Alder Hey, UK. Eur J Cancer 41(14): 2132-2140 (Pubitemid 41337955)
13. Clavijo J, Gomez-de-Segura IA, Gomez-Garcia L, Vallejo- Cremades MT, Sanchez M, de Miguel E (2004) Growth hormone protects the intestines but not the tumour from 5-fluorouracil toxicity in the short term in the rat. Eur J Gastroenterol Hepatol 16(1):75-82 (Pubitemid 39043706)
14. Kucuk C, Ozkan M, Akgun H, Muhtaroglu S, Sozuer E (2005) The effect of granulocyte macrophage-colony stimulating factor on bacterial translocation after administration of 5-fluorouracil in rats. J Surg Res 128(1):15-20 (Pubitemid 41188204)
15. Nose S, Wasa M, Tazuke Y, Owari M, Fukuzawa M (2010) Cisplatin upregulates glutamine transport in human intestinal epithelial cells: the protective mechanism of glutamine on intestinal mucosa after chemotherapy. JPEN J Parenter Enteral Nutr 34(5):530-537
16. Arrick BA, Nathan CF (1984) Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res 44(10):4224-4232 (Pubitemid 14008726)
17. Mitchell JB, Russo A (1987) The role of glutathione in radiation and drug induced cytotoxicity. Br J Cancer Suppl 8:96-104 (Pubitemid 17108366)
18. Russo A, Carmichael J, Friedman N, DeGraff W, Tochner Z, Glatstein E, Mitchell JB (1986) The roles of intracellular glutathione in antineoplastic chemotherapy. Int J Radiat Oncol Biol Phys 12(8):1347-1354 (Pubitemid 16030614)
19. Rabik CA, Dolan ME (2007) Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 33(1):9-23 (Pubitemid 46137553)
20. Hong RW, Rounds JD, Helton WS, Robinson MK, Wilmore DW (1992) Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 215(2):114-119
21. Tazuke Y, Wasa M, Shimizu Y, Wang HS, Okada A (2003) Alanyl-glutamine- supplemented parenteral nutrition prevents intestinal ischemia-reperfusion injury in rats. JPEN J Parenter Enteral Nutr 27(2):110-115 (Pubitemid 36268528)
22. Satoh J, Tsujikawa T, Fujiyama Y, Bamba T (2003) Nutritional benefits of enteral alanyl-glutamine supplementation on rat small intestinal damage induced by cyclophosphamide. J Gastroenterol Hepatol 18(6):719-725 (Pubitemid 36791712)
23. Cerchietti LC, Navigante AH, Lutteral MA, Castro MA, Kirchuk R, Bonomi M, Cabalar ME, Roth B, Negretti G, Sheinker B, Uchima P (2006) Double-blinded, placebo-controlled trial on intravenous l-alanyl-l-glutamine in the incidence of oral mucositis following chemoradiotherapy in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys 65(5):1330-1337 (Pubitemid 44425223)