A prospective study of septicaemia on a paediatric oncology unit: A three-year experience at the Royal Liverpool Children's Hospital, Alder Hey, UK

European Journal of Cancer

Volumn 41, Issue 14, 2005, Pages 2132-2140

  Paulus, S C ^a   Van Saene, H K F ^a   Hemsworth, S ^a   Hughes, J ^a   Ng, A ^a   Pizer, B L ^a  

^a ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

Cancer; Child; Infection; Oncology; Septicaemia

Indexed keywords

AMIKACIN; AMPHOTERICIN B; ANTIBIOTIC AGENT; CEFTAZIDIME; CIPROFLOXACIN; NETILMICIN; PIPERACILLIN; POLYMYXIN B; TEICOPLANIN; TOBRAMYCIN; VANCOMYCIN;

ADOLESCENT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; CANDIDA; CANDIDIASIS; CHILD; CHILDHOOD CANCER; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DEATH; FEMALE; HUMAN; HYGIENE; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; MICROORGANISM; MORTALITY; ONCOLOGY; PEDIATRICS; PRIORITY JOURNAL; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; RECTUM; SEPTICEMIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; SYSTEMIC THERAPY; THROAT; UNITED KINGDOM;

ADOLESCENT; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; DRUG RESISTANCE; ENGLAND; FEMALE; HOSPITALS, PEDIATRIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFECTION CONTROL; MALE; NEOPLASMS; PROSPECTIVE STUDIES; SEPSIS;

EID: 25144496930     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.04.037     Document Type: Article

References (45)

1. P.H.B. Bolton-Maggs, H.K.F. van Saene, and H.P. McDowell Clinical evaluation of ticarcillin, with clavulanic acid, and gentamicin in the treatment of febrile episodes in neutropenic children J Antimicrob Chemother 27 1991 669 676
2. L.E. Rhodes, H.K.F. van Saene, and S. White Microbial carriage, sepsis, infection and acute graft-versus-host-disease in the first 25 BMT at the Royal Liverpool Children's Hospital Bone Marrow Transplant 11 1993 261 269
3. V.M. Aquino, A. Pappo, and G.R. Buchanan The changing epidemiology of bacteraemia in neutropenic children with cancer Pediatr Infect Dis J 14 1995 140 143
4. I. Hann, C. Viscoli, and M. Paesman A comparison of outcome from febrile neutropenic episodes in children compared with adults: results from four EORTC studies Br J Haematol 99 1997 580 588
5. J. Rahiala, M. Perkkiö, and P. Riikonen Infections occurring during causes of anticancer chemotherapy in children with ALL Pediatr Hematol Oncol 15 1998 165 174
6. G. Wehl, F. Allerberger, and A. Heitger Trends in infection morbidity in a pediatric oncology ward, 1986-1995 Med Pediatr Oncol 32 1999 336 343
7. C. Viscoli, E. Castagnola, and M. Giacchino Blood stream infections in children with cancer: a multicentre surveillance study of the Italian association of paediatric haematology and oncology Eur J Cancer 35 1999 770 774
8. M.D. van de Wetering, J. Poole, and I. Friedland Bacteraemia in a paediatric oncology unit in South Africa Med Pediatr Oncol 37 2001 525 531
9. R. Haupt, M. Romanengo, and T. Fears Incidence of blood stream infections and invasive mycoses in children undergoing treatment for solid tumors: a 12-year experience at a single Italian institution Eur J Cancer 37 2001 2413 2419
10. E. Kurrle, S. Bhaduri, and D. Krieger Risk factors for infections of the oropharynx and the respiratory tract in patients with acute leukaemia J Infect Dis 144 1981 128 136
11. C.H. Tancrède, and A.O. Andremont Bacterial translocation and Gram-negative bacteremia in patients with hematological malignancies J Infect Dis 152 1985 99 103
12. B. Lina, F. Forey, and J. Troncy Oral source of Staphylococcus epidermidis septicaemia in a neutropenic patient Eur J Clin Microbiol Infect Dis 13 1994 773 774
13. H.F. Kennedy, D. Morrison, and M.E. Kaufmann Origins of Staphylococcus epidermidis and Streptococcus oralis causing bacteraemia in a bone marrow transplant patient J Med Microbiol 49 2000 367 370
14. I. Das, C. Philpott, and R.H. George Central venous catheter-related septicaemia in paediatric cancer patients J Hosp Infect 36 1997 67 76
15. M.G. Karlowicz, O.J. Furigay, and D.P. Croitoru Central venous catheter removal versus in situ treatment in neonates with coagulase-negative staphylococcal bacteremia Pediatr Infect Dis J 21 2002 22 27
16. T.C. Eickhoff Antibiotics and nosocomial infections J.V. Bennett P.S. Brachmann Hospital infections 3rd ed. 1992 Little, Brown and Company Boston 245 264
17. P. de Man, B.A.N. Verhoeven, and H.A. Verburgh An antibiotic policy to prevent emergence of resistant bacilli Lancet 355 2000 973 978
18. C.J. Donskey, T.K. Chowdry, and M.T. Hecker Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonised patients N Engl J Med 343 2000 1925 1932
19. B.A. Cunha Effective antibiotic resistance control strategies Lancet 357 2001 1307 1308
20. R.W. Lacey, V.L. Lord, and G.L. Howson Double-blind study to compare the selection of antibiotic resistance by amoxycillin or cephradine in the commensal flora Lancet ii 1983 529 532
21. G. Zobel, M. Kuttnig, and H.M. Grubbauer Reduction of colonization and infection rate during pediatric intensive care by selective decontamination of the digestive tract Crit Care Med 19 1991 1242 1246
22. S.D. Smith, R.J. Jackson, and C.J. Hannakan Selective decontamination in pediatric liver transplants Transplantation 55 1993 1306 1309
23. F. Ruza, F. Alvarado, and R. Herruzo Prevention of nosocomial infection in a pediatric intensive care unit [PICU] through the use of selective digestive decontamination Eur J Epidemiol 14 1998 719 727
24. J.P. Barret, M.G. Jeschke, and D.N. Herndon Selective decontamination of the digestive tract in severely burned pediatric patients Burns 27 2001 439 445
25. H.K.F. van Saene, V. Damjanovic, and S.R. Alcock Basics in microbiology for the patient requiring intensive care Curr Anaesth Crit Care 12 2001 6 1726
26. National Committee for Clinical Laboratory Standards Methods for dilution antimicrobial susceptibility testing for bacteria that grow anaerobically 3rd ed. 1993 National Committee for Clinical Laboratory Standards Villanora, PA [Approved standard M7-A3.27]
27. H.K.F. van Saene, N. Taylor, and S.C. Donnell Gut overgrowth with abnormal flora; the missing link in parenteral nutrition-related sepsis in surgical neonates Eur J Clin Nutr 57 2003 548 553
28. G.P. Bodey, M. Buckley, and Y.S. Sathe Quantitative relationships between circulating leukocytes and infection in patients with acute leukaemia Ann Int Med 64 1966 328 39929
29. European Organization for Research and Treatment of Cancer [EORTC] International Antimicrobial Therapy Co-operative Group and the National Cancer Institute of Canada - Clinical Trials Group. Vancomycin added to empirical antibiotic therapy for fever in granulocytopenic cancer patients J Infect Dis 163 1991 951 958
30. A. Cometta, W.V. Kern, and R. De Bock Vancomycin versus placebo for treating persistent fever in patients with neutropenic cancer receiving piperacillin-tazobactam monotherapy Clin Infect Dis 37 2003 382 389
31. S.C. Schimpff Surveillance cultures J Infect Dis 144 1981 81 84
32. L. Silvestri, R.E. Sarginson, and J. Hughes Most nosocomial pneumonias are not due to nosocomial bacteria in ventilated patients. Evaluation of accuracy of the 48 h time cut-off using carriage as the gold standard Anaesth Intensive Care 30 2002 275 282
33. R.E. Sarginson, N. Taylor, and N. Reilly Infection in pediatric critical illness: a prospective four year study based on knowledge of the carrier state Crit Care Med 32 3 2004 839 847
34. A. Liberati, R. D'Amico, and Pifferi Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care Cochrane Database Syst Rev 1 2004 CD000022
35. G. Grisaru-Soen, L. Lerner-Geva, and N. Keller Pseudomonas aeruginosa bacteremia in children: analysis of trends in prevalence, antibiotic resistance and prognostic factors Pediatr Infect Dis J 19 2000 959 963
36. E. de Jonge, M.J. Schultz, and L. Spanjaard Effects of selective decontamination of the digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial Lancet 362 2003 1011 1016
37. C. Brun Buisson, P. Legrand, and A. Rauss Intestinal decontamination for control of nosocomial multi-resistant Gram-negative bacilli Ann Intern Med 110 1989 873 881
38. J.M.J. Hammond, and P.D. Potgieter Long-term effects of selective decontamination on antimicrobial resistance Crit Care Med 23 1995 637 645
39. C.P. Stoutenbeek, H.K.F. van Saene, and D.F. Zandstra The effect of oral non-absorbable antibiotics on the emergence of resistant bacteria in patients in an intensive care unit J Antimicrob Chemother 19 1987 513 520
40. W. Lingnau, J. Berger, and F. Javorsky Changing bacterial ecology during a five year period of selective intestinal decontamination J Hosp Infect 39 1998 195 206
41. M. Leone, J. Albanese, and F. Antonini Long-term [6 year] effect of selective digestive decontamination on antimicrobial resistance in intensive care, multitrauma patients Crit Care Med 31 2003 2090 2095
42. J.E. Fergie, S.J. Shema, and L. Lott Pseudomonas aeruginosa bacteremia in immuno-compromised children: analysis of factors associated with poor outcome Clin Infect Dis 18 1994 390 394
43. M.A. de la Cal, E. Cerda, and H.K.F. van Saene Effectiveness and safety of enteral vancomycin to control endemicity of methicillin-resistant Staphylococcus aureus in a medical/surgical intensive care unit J Hosp Infect 56 2004 175 183
44. G.W.M. Tetteroo, J.H.T. Wagenvoort, and H.A. Bruining Bacteriology of selective decontamination: efficacy and rebound colonization J Antimicrob Chemother 34 1994 139 148
45. A. Abella, M.A. de la Cal, and E. Cerda Control of MRSA endemicity with enteral vancomycin in a burn intensive care unit Intensive Care Med 30 Suppl. 1 2004 S145 [Abstract 556]