Growth hormone protects the intestines but not the tumour from 5-fluorouracil toxicity in the short term in the rat

European Journal of Gastroenterology and Hepatology

Volumn 16, Issue 1, 2004, Pages 75-82

  Clavijo, Julio ^a   Gomez De Segura, Ignacio A ^a   Gomez García, Lourdes ^a   Vallejo Cremades, María T ^a   Sanchez, Miriam ^a   De Miguel, Enrique ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Adenocarcinoma; Apoptosis; Colon; Enteritis; Fluorouracil; Growth hormone; Intestines; Protein p53

Indexed keywords

FLUOROURACIL; GROWTH HORMONE; PROTEIN P53; ANTINEOPLASTIC ANTIMETABOLITE; GROWTH HORMONE RECEPTOR;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER TRANSPLANTATION; CELL PROLIFERATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; CRYPT CELL; DRUG EFFECT; GASTROINTESTINAL TOXICITY; INTESTINE; MALE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; TUMOR CELL; TUMOR GROWTH; ANIMAL; BACTERIAL TRANSLOCATION; BODY WEIGHT; COLON TUMOR; RAT STRAIN; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BACTERIAL TRANSLOCATION; BODY WEIGHT; CELL LINE, TUMOR; COLONIC NEOPLASMS; FLUOROURACIL; GROWTH HORMONE; INTESTINES; MALE; RATS; RATS, INBRED STRAINS; RECEPTORS, SOMATOTROPIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 3042699526     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200401000-00012     Document Type: Article

References (24)

1. Pritchard DM, Watson AJ, Potten CS, Jackman AL, Hickman JA. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc Natl Acad Sci USA 1997; 94:1795-1799.
2. Pritchard DM, Jackman A, Potten CS, Hickman JA. Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity. Toxicol Lett 1998; 102/103:19-27.
3. Pritchard DM, Potten CS, Hickman JA. The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. Cancer Res 1998; 58:5453-5465.
4. Chu KU, Higashide S, Evers BM, Rajaraman S, Ishizuka J, Townsend CM Jr, Thompson JC. Bombesin improves survival from methotrexate-induced enterocolitis. Ann Surg 1994; 220:570-576.
5. Vagianos C, Karatzas T, Scopa CD, Panagopoulos C, Tsoni I, Spiliopoulou I, Kalfarentzos F. Neurotensin reduces microbial translocation and improves intestinal mucosa integrity after abdominal radiation. Eur Surg Res 1992; 24:77-83.
6. Howarth GS, Cool JC, Bourne AJ, Ballard FJ, Read LC. Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate. Growth Factors 1998; 15:279-292.
7. Petschow BW, Carter DL, Hutton GD. Influence of orally administered epidermal growth factor on normal and damaged intestinal mucosa in rats. JPEN 1993; 17:49-58.
8. Farrell CL, Bready JV, Rex KL, Chen JN, DiPalma CR, Whitcomb KL, et al. Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 1998; 58:933-939.
9. Howarth GS, Fraser R, Frisby CL, Schirmer MB, Yeoh EK. Effects of insulin-like growth factor-I administration on radiation enteritis in rats. Scand J Gastroenterol 1997; 32:1118-1124.
10. Gomez-de-Segura IA, Prieto I, Grande AG, Garcia P, Guerra A, Mendez J, De Miguel E. Growth hormone reduces mortality and bacterial translocation in irradiated rats. Acta Oncol 1998; 37:179-185.
11. Ortega M, Gomez de Segura IA, Vazquez I, Lopez JM, Ladron de Guevara MC, De-Miguel E. Growth hormone plus a hyperproteic diet effects on methotrexate-induced injury in rat intestines. Acta Oncol 2001; 40:622-628.
12. Vazquez I, Gomez-de-Segura IA, Grande AG, Escribano A, Gonzalez-Gancedo P, Gomez A, et al. Protective effect of enriched diet plus growth hormone administration on radiation-induced intestinal injury and on its evolutionary pattern in the rat. Dig Dis Sci1999; 44:2350-2358.
13. Donoway RB, Torosian MH. Growth hormone inhibits tumor metastases. Surg Forum 1989; 40:413-415.
14. Binnerts A, Uittterlinden P, Hofland LJ, van-Koetsveld P, Lamberts SW. The in vitro and in vivo effects of human growth hormone administration on tumor growth of rats bearing a transplantable rat pituitary tumor (7315b). Eur J Cancer 1990; 26:269-276.
15. Harrison LE, Blumberg D, Berman R, Ng B, Hochwald S, Brennan MF, Burt M. Effect of human growth hormone on human pancreatic carcinoma growth, protein, and cell cycle kinetics. J Surg Res 1996; 61:317-322.
16. Wolf RF, Pearlstone DB, Newman E, Heslin MJ, Gonenne A, Burt ME, Brennan MF. Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients. Ann Surg 1992; 216:280-288.
17. Zhang W, Frankel WL, Bain A, Choi D, Klurfeld DM, Rombeau JL. Glutamine reduces bacterial translocation after small bowel transplantation in cyclosporine-treated rats. J Surg Res 1995; 58:159-164.
18. Wang J, Chi DS, Kalin GB, Sosinski C, Miller LE, Burja I, Thomas E. Helicobacter pylori infection and oncogene expressions in gastric carcinoma and its precursor lesions. Dig Dis Sci 2002; 47:107-113.
19. Pocard M, Bras G, Hamelin R, Northover J, Poupon MF. Response to 5-fluorouracil of orthotopically xenografted human colon cancers with a microsatellite instability: influence of P53 status. Anticancer Res 2000; 20:85-90.
20. Zaugg K, Rocha S, Resch H, Hegyi I, Oehler C, Glanzmann C, et al. Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412. Cancer Res 2001; 61:732-738.
21. Wadman M. EU warns on growth-hormone cancer risk. Nature 1999; 399:8.
22. Ng EH, Rock CS, Lazarus D, Staiano-Coico L, Fischer E, Moldawer LL, Lowry SF. Impact of exogenous growth hormone on host preservation and tumor cell-cycle distribution in a rat sarcoma model. J Surg Res 1991; 51:99-105.
23. Giesbert S, Panzer S, Kovar H, Fischer S, Printz D, Gadner H, Panzer-Grumayer ER. Acute leukemias express a functional receptor for the human growth hormone. Ann Hematol 1997; 74:253-257.
24. Fiebig HH, Dengler W, Hendriks HR. No evidence of tumor growth stimulation in human tumors in vitro following treatment with recombinant human growth hormone. Anticancer Drugs 2000; 11:659-664.