Confirmation and prevention of intestinal barrier dysfunction and bacterial translocation caused by methotrexate

Digestive Diseases and Sciences

Volumn 51, Issue 9, 2006, Pages 1549-1556

  Song, Desheng ^a   Shi, Bin ^a   Xue, Hua ^a   Li, Yousheng ^a   Yang, Xiaodong ^a   Yu, Baojun ^a   Xu, Zhe ^a   Liu, Fukun ^a   Li, Jieshou ^a  

^a JINLING HOSPITAL   (China)

Author keywords

Bacterial translocation; Chemotherapy; Granulocyte colony stimulating factor; Intestinal barrier dysfunction; Methotrexate

Indexed keywords

AMPICILLIN; GRANULOCYTE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; LACTULOSE; MANNITOL; METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; BACTERIUM CULTURE; CHEMOTHERAPY; CONTROLLED STUDY; CULTURE MEDIUM; ESCHERICHIA COLI; FEEDING; ILEUM; INTESTINE VILLUS ATROPHY; KIDNEY; LIVER; MALE; MEMBRANE PERMEABILITY; MESENTERY LYMPH NODE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE DISEASE; SPLEEN; URINARY EXCRETION;

ANIMALS; BACTERIAL TRANSLOCATION; COLONY COUNT, MICROBIAL; DNA, BACTERIAL; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; GRANULOCYTE COLONY-STIMULATING FACTOR; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; METHOTREXATE; MICROSCOPY, FLUORESCENCE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33748593139     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-9058-0     Document Type: Article

References (35)

1. Berg RD, Garlington AW (1979) Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 23:403-411
2. Cruz N, Alvarez X, Berg R, Deitch EA (1994) Bacterial translocation across enterocytes: Results of a study of bacterial-enterocyte interactions utilizing Caco-2 cells. Shock 1:67-72
3. Berg R (1999) Bacterial translocation from the gastrointestinal tract. Adv Exp Med Biol 473:11-30
4. Carneir B, Araujo D, Cavalcante M, Carvalho G, Brito G, Lima V, Monteiro S, Santos F, Ribeir R, Lima A (2004) Intestinal barrier function and secretion in methotrexate-induced rat intestinal mucositis. Dig Dis Sci 49:65-72
5. Wiehart RH, Gasson JC, Golde DW (1989) Colony stimulating factors and host defense. Ann Intern Med 110:297-303
6. Crawford J, Ozer H, Stoller R, Johnson D, Lyman G, Tabbara I, Kris M, Grous J, Picozzi V, Rousch G, Smith R, Gradhisar W, Yahanda A, Vincent M, Stewart Glaspy J (1991) Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 325:164-170
7. Nelson S (1994) Role of granulocyte colony-stimulating factor in the immune response to acute bacterial infection in the nonneutropenic host: An overview. Clin Infect Dis 2:197-204
8. Colak T, Ipek T, Paksoy M, Polat E, Uygun N, Kayabasi B (2001) The effects of cefephim, g-csf, and sucralfate on bacterial translocation in experimentally induced acute pancreatitis. Surg Today 31:502-506
9. Akin L, Batkin A, Celenk T, Nogay A, Gunduz M (1997) Effects of granulocyte colony stimulating factor and vitamin E on bacterial translocation in complete mechanical intestinal obstructions in an experimental study. Br J Surg 84(Suppl 2):67
10. Cubitt AB, Heim R, Adams SR, Boyd AE, Gross LA, Tsien RY (1995) Understanding, improving and using green fluorescent proteins. Trends Biochem Sci 20:448-455
11. Chalfie M, Tu Y, Euskirchen G, Ward WW, Prashe DC (1994) Green fluorescent protein as a marker for gene expression. Science 263:802-805
12. Sambrook J, Fritsch E, Maniatis T (1989) Molecular cloning: A laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
13. Lima AA, Silva TM, Gifoni AM, Barrett LJ, McAuliffe IT, Bao Y, Fox JW, Fedorko DP, Guerrant RL (1997) Mucosal injury and disruption of intestinal barrier function in HIV-infected individuals with and without diarrhea and cryptosporidiosis in northeast Brazil. Am J Gastroenterol 92:1861-1866
14. Pearson AD, Eastham EJ, Laker MF, Craft AW, Nelson R (1982) Intestinal permeability in children with Crohn's disease and coeliac disease. Br Med J 285:20-21
15. Deitch EA (1990) Intestinal permeability is increased in burn patients shortly after injury. Surgery 107:411-416
16. Sundstrom GM, Wahlin A, Nordin-Andersson I, Suhr OB (1998) Intestinal permeability in patients with acute myeloid leukemia. Eur J Haematol 61:250-254
17. Wyatt J, Vogelsang H, Hubl W, Waldhoer T, Lochs H (1993) Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 341:1437-1439
18. Kohout P, Cerman J, Bratova M, Zadak Z (1999) Small bowel permeability in patients with cytostatic therapy. Nutrition 15:546-549
19. Maejima K, Deitch E, Berg R (1984) Promotion by burn stress of the translocation of bacteria from the gastrointestinal tracts of mice. Arch Surg 119:166-172
20. Maejima K, Deitch EA, Berg RD (1984) Bacterial translocation from the gastrointestinal tracts of rats receiving thermal injury. Infect Immun 43:6-10
21. Baker JW, Deitch EA, Li M, Berg RD, Specian RD (1988) Hemorrhagic shock induces bacterial translocation from the gut. J Trauma 28:896-906
22. Deitch EA, Berg R, Specian R (1987) Endotoxin promotes the translocation of bacteria from the gut. Arch Surg 122:185-190
23. Deitch EA, Ma W-J, Ma L, Berg R, Specian RD (1989) Endotoxininduced bacterial translocation: A study of mechanisms. Surgery 106:292-300
24. Deitch EA (1989) Simple intestinal obstruction causes bacterial translocation in man. Arch Surg 124:699-701
25. Berg RD, Wommack E, Deitch EA (1988) Immunosuppression and intestinal bacterial overgrowth synergistically promote bacterial translocation. Arch Surg 123:1359-1364
26. Ambrose NS, Johnson M, Burdon DW, Keighley MR (1984) Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery. Br J Surg 71:623-625
27. Alverdy JC, Aoys E, Moss GS (1988) Total parenteral nutrition promotes bacterial translocation from the gut. Surgery 104:185-190
28. Redan JA, Rush BF, Lysz TW, Smith S, Machiedo GW (1990) Organ distribution of gut-derived bacteria caused by bowel manipulation or ischemia. Am J Surg 159:85-190
29. Alexander JW, Gianotti L, Pyles T, Carey MA, Babcock GF (1991) Distribution and survival of Escherichia coli translocating from the intestine after thermal injury. Ann Surg 213:558-567
30. Gennari R, Alexande JW, Eaves-Pyles T (1994) IFN-gamma decreases translocation and improves survival following transfusion and thermal injury. J Surg Res 56:530-537
31. Wells CL, Maddaus MA, Simmons RL (1987) Role of the macrophage in the translocation of intestinal bacteria. Arch Surg 122:48-53
32. Kazantsev GB, Hecht DW, Fedorak IJ, Gattuso P, Thompson K, Djuricin G, Prinz RA (1994) Plasmid labeling confirms bacterial translocation in pancreatitis. Am J Surg 167:201-207
33. Gersting JA, Christensen RD, Calhoun DA (2004) Effects of enterally administering granulocyte colony-stimulating factor to suckling mice. Pediatr Res 55:802-806
34. Colak T, Ipek T, Paksoy M, Polat E, Uygun N, Kayabasi B (2001) The effects of cefephim, G-CSF and sucralfate on bacterial translocation in experimentally induced acute pancreatitis. Surg Today 31:502-506
35. Rao R, Prinz RA, Kazantsev GB, Hecht D, Gattuso P, Jacobs HK, Djuricin G, Castelli M (1996) Effects of granulocyte colony stimulating factor in severe pancreatitis. Surgery 119:657-663