Survivin knockdown enhances gastric cancer cell sensitivity to radiation and chemotherapy in vitro and in nude mice

American Journal of the Medical Sciences

Volumn 344, Issue 1, 2012, Pages 52-58

  Shen, Xin ^a   Zheng, Jian Yong ^a   Shi, Hai ^a   Zhang, Zhang ^a   Wang, Wei Zhong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chemotherapy; Gastric cancer; Radiation; shRNA; Survivin

Indexed keywords

CISPLATIN; FLUOROURACIL; MESSENGER RNA; SHORT HAIRPIN RNA; SURVIVIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL STRAIN SGC7901; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN EXPRESSION; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STOMACH CANCER; TREATMENT RESPONSE; TUMOR XENOGRAFT; WESTERN BLOTTING; X IRRADIATION;

EID: 84863471855     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e318239c4ee     Document Type: Article

References (20)

1. Global Facts and Figures 2007. Available at: www.cancer.org. Accessed May 1, 2011.
2. Section of Cancer Information, IARC. GLOBOCAN, 2008. Available at: www.who.int. Accessed May 1, 2011.
3. Gou HF, Chen XC, Zhu J, et al. Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications. J Exp Clin Cancer Res 2011;30:14.
4. Arkenau HT. Gastric cancer in the era of molecularly targeted agents: current drug development strategies. J Cancer Res Clin Oncol 2009; 135:855-66.
5. Yasui W, Sentani K, Motoshita J, et al. Molecular pathobiology of gastric cancer. Scand J Surg 2006;95:225-31.
6. Chen T, Deng C. Inhibitory effect of siRNA targeting survivin in gastric cancer MGC-803 cells. Int Immunopharmacol 2008;8:1006-11.
7. Miao GY, Lu QM, Zhang XL. Downregulation of survivin by RNAi inhibits growth of human gastric carcinoma cells. World J Gastroen-terol 2007;13:1170-4.
8. Sah NK, Khan Z, Khan GJ, et al. Structural, functional and therapeutic biology of survivin. Cancer Lett 2006;244:164-71.
9. Pennati M, Folini M, Zaffaroni N. Targeting survivin in cancer therapy: fulfilled promises and open questions. Carcinogenesis 2007;28:1133-9.
10. Altieri DC. Validating survivin as a cancer therapeutic target. Nat Rev Cancer 2003;3:46-54.
11. Song H, Xin XY, Xiao F, et al. Survivin gene RNA interference inhibits proliferation, induces apoptosis, and enhances radiosensitivity in HeLa cells. Eur J Obstet Gynecol Reprod Biol 2008;136:83-9.
12. Croci DO, Cogno IS, Vittar NB, et al. Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway. J Cell Biochem 2008;105: 381-90.
13. Zaffaroni N, Costa A, Pennati M, et al. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol 2007;29:453-66.
14. Cai M, Wang GB, Tao KX, et al. Enhanced chemotherapy sensitivity of human colon cancer cells to 5-fluorouracil by siRNA recombinant expression vector targeting survivin gene. Chin Med Sci J 2009;24: 97-101.
15. Virrey JJ, Guan S, Li W, et al. Increased survivin expression confers chemoresistance to tumor-associated endothelial cells. Am J Pathol 2008;173:575-85.
16. Yang H, Fu JH, Hu Y, et al. Influence of SiRNA targeting survivin on chemosensitivity of H460/cDDP lung cancer cells. J Int Med Res 2008; 36:734-47.
17. Fan LF, Dong WG, Jiang CQ, et al. Role of hypoxia-inducible factor-1 alpha and survivin in colorectal carcinoma progression. Int J Colorec-tal Dis 2008;23:1057-64.
18. Moriai R, Tsuji N, Moriai M, et al. Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells. Breast Cancer Res Treat 2009;117:261-71.
19. Ma R, Chen XH, Zhang QF, et al. Exploration on the increased sensitivity to docetaxel and reversing mechanism of drug resistance of antisense survivin RNA in gastric cancer cell line SGC7901 cells. Zhonghua Zhong Liu Za Zhi 2007;29:89-92.
20. Hannan GJ. RNA interference[J]. Nature 2002;418:244-51.