Improvement of oral bioavailability of glycyrrhizin by sodium deoxycholate/phospholipid-mixed nanomicelles

Journal of Drug Targeting

Volumn 20, Issue 7, 2012, Pages 615-622

  Jin, Shixiao ^a   Fu, Shanshan ^a   Han, Jin ^a   Jin, Shiying ^a   Lv, Qingyuan ^a   Lu, Yi ^b   Qi, Jianping ^b   Wu, Wei ^b   Yuan, Hailong ^a  

^a 302 MILITARY HOSPITAL   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Acute liver injury; Glycyrrhizin; Oral bioavailability; Pharmacodynamics; Pharmacokinetics; Sodium deoxycholate phospholipid mixed nanomicelles

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; BIFENDATE; CARBON TETRACHLORIDE; DEOXYCHOLATE SODIUM; DIAMMONIUM GLYCYRRHIZINATE; GASTROINTESTINAL AGENT; GLYCYRRHIZIC ACID; NANOPARTICLE; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; GASTROINTESTINAL TRACT; LIVER; LIVER FUNCTION; LIVER INJURY; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLE; NONHUMAN; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL AVAILABILITY; BIPHENYL COMPOUNDS; CARBON TETRACHLORIDE; DEOXYCHOLIC ACID; DISEASE MODELS, ANIMAL; DRUG STABILITY; GLYCYRRHIZIC ACID; LIVER; MALE; MICELLES; NANOCONJUGATES; PARTICLE SIZE; PHOSPHOLIPIDS; RATS; RATS, WISTAR; SURFACE PROPERTIES;

EID: 84863469971     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2012.702770     Document Type: Article

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